DegronMD

Uniprot ID: Q13433

Source protein: Zinc transporter ZIP6

Source gene: SLC39A6

Class: LIG_APCC_ABBAyCdc20_2

Location: 89:95

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8182

ASA_SCORE: 107.1857

COIL: 0.6907

CONS_SCORE: 0.2722

DSS_SCORE: 0.5521

HELIX: 0.0304

FCONS_SCORE: 1.1437

RIG_SCORE: 0.6585

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D101Y	TCGA-44-6778	LUAD	TCGA	RIHIHHD	LIG_APCC_ABBAyCdc20_2	0.1667
p.D101Y	DO25603	LUAD	ICGC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	0.1667
p.H105Q	TCGA-A5-A0G2	UCEC	TCGA	RIHIHHD	LIG_APCC_ABBAyCdc20_2	0.0556
p.H105Q	DO41235	UCEC	ICGC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	0.0556
p.D95G	TCGA-AP-A0LM	UCEC	TCGA	RIHIHHD	LIG_APCC_ABBAyCdc20_2	0.7198
p.D95G	DO43306	UCEC	ICGC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	0.7198
p.H91Y	TCGA-EE-A181	SKCM	TCGA	RIHIHHD	LIG_APCC_ABBAyCdc20_2	0.6118
p.H91Y	DO37444	SKCM	ICGC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	0.6118
p.H93N	DO228971	LICA	ICGC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	0.7423
p.H93N	DO229018	LICA	ICGC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	0.7423
p.Q80K	DO229028	LICA	ICGC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	0.0833
p.H99N	DO229026	LICA	ICGC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	0.2222
p.D97E	DO46850	RECA	ICGC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	0.2778
p.H93Y	SIDM01293	Colorectal Carcinoma	GDSC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	0.6118
p.G83D	SIDM00217	Colorectal Carcinoma	GDSC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	0.1667
p.G83D	ACH-000999	Colon/Colorectal Cancer	CCLE	RIHIHHD	LIG_APCC_ABBAyCdc20_2	0.1667
p.G83D	SNU-1040	large_intestine	COSMIC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	0.1667
p.S84R	IGROV-1	ovary	COSMIC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13433	Zinc transporter ZIP6	LIG_APCC_ABBAyCdc20_2	89:95	RIHIHHD	APC,CDC20,FZR1	0.8182	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons