DegronMD - Q8WWM7(ATXN2L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A889V	TCGA-12-5299	GBM	TCGA	PATTPTGS	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.1389
p.A889V	TCGA-TM-A84J	LGG	TCGA	PATTPTGS	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.1389
p.A889V	DO13330	GBM	ICGC	PATTPTGS	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.1389
p.A889V	DO50236	LGG	ICGC	PATTPTGS	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.1389
p.P783A	TCGA-13-0893	OV	TCGA	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation altering degron motif	0.7503
p.P783A	DO29002	OV	ICGC	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation altering degron motif	0.7503
p.R365G	TCGA-22-A5C4	LUSC	TCGA	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.1389
p.R365G	DO45446	LUSC	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.1389
p.A772V	TCGA-2W-A8YY	CESC	TCGA	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.1389
p.A772V	DO223732	CESC	ICGC	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.1389
p.R382C	TCGA-66-2791	LUSC	TCGA	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.2778
p.R382C	TCGA-86-8056	LUAD	TCGA	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.2778
p.R382C	TCGA-H7-8501	HNSC	TCGA	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.2778
p.R382C	TCGA-XF-A9T0	BLCA	TCGA	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.2778
p.R382C	DO48401	BLCA	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.2778
p.R382C	DO48457	BLCA	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.2778
p.R382C	DO51920	BLCA	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.2778
p.R382C	DO222744	ESCA	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.2778
p.R382C	DO14202	HNSC	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.2778
p.R382C	DO24950	LUAD	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.2778
p.R382C	DO26435	LUSC	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.2778
p.G362V	TCGA-85-8287	LUSC	TCGA	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.0556
p.G362V	DO27492	LUSC	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.0556
p.A890P	TCGA-AJ-A3BG	UCEC	TCGA	PATTPTGS	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.1111
p.A890P	DO42633	UCEC	ICGC	PATTPTGS	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.1111
p.P884S	TCGA-AX-A0J1	UCEC	TCGA	PATTPTGS	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.2778
p.P884S	DO41199	UCEC	ICGC	PATTPTGS	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.2778
p.G371D	TCGA-BH-A0HX	BRCA	TCGA	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.3056
p.G371D	DO5891	BRCA	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.3056
p.A865G	TCGA-BR-4292	STAD	TCGA	PATTPTGS	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.0556
p.A865G	DO38495	STAD	ICGC	PATTPTGS	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.0556
p.P466S	TCGA-CR-7404	HNSC	TCGA	VPTSS	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.1944
p.P466S	DO14420	HNSC	ICGC	VPTSS	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.1944
p.H871N	TCGA-CV-7238	HNSC	TCGA	PATTPTGS	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.2222
p.H871N	DO15246	HNSC	ICGC	PATTPTGS	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.2222
p.H830Y	TCGA-D3-A8GI	SKCM	TCGA	VSSST	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.1944
p.H830Y	DO50284	SKCM	ICGC	VSSST	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.1944
p.H386Y	TCGA-EE-A2GC	SKCM	TCGA	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.1667
p.H386Y	DO222749	MELA	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.1667
p.H386Y	DO37839	SKCM	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.1667
p.P479H	TCGA-EE-A3AC	SKCM	TCGA	PVTSS	DEG_SPOP_SBC_1	479:483	Mutation altering degron motif	0.7694
p.P479H	DO37631	SKCM	ICGC	PVTSS	DEG_SPOP_SBC_1	479:483	Mutation altering degron motif	0.7694
p.P843L	TCGA-EE-A3J3	SKCM	TCGA	VSSST	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.2222
p.P843L	DO48652	SKCM	ICGC	VSSST	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.2222
p.P879H	TCGA-FI-A2D5	UCEC	TCGA	PATTPTGS	DEG_SCF_FBW7_1	875:882	Mutation altering degron motif	0.7694
p.P879H	DO41331	UCEC	ICGC	PATTPTGS	DEG_SCF_FBW7_1	875:882	Mutation altering degron motif	0.7694
p.S369A	TCGA-GN-A26C	SKCM	TCGA	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.25
p.S369A	DO37782	SKCM	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.25
p.S369F	TCGA-GN-A26C	SKCM	TCGA	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.25
p.S369F	DO37782	SKCM	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.25
p.A889T	TCGA-HU-A4GT	STAD	TCGA	PATTPTGS	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.1389
p.A889T	DO48020	STAD	ICGC	PATTPTGS	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.1389
p.G468S	TCGA-KK-A59V	PRAD	TCGA	VPTSS	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.25
p.G468S	DO51346	PRAD	ICGC	VPTSS	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.25
p.P792S	TCGA-QG-A5Z2	COAD	TCGA	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.1667
p.P792S	DO44096	COAD	ICGC	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.1667
p.G363R	TCGA-QK-A8Z8	HNSC	TCGA	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.0833
p.G363R	DO52097	HNSC	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.0833
p.R373W	TCGA-WS-AB45	COAD	TCGA	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation altering degron motif	0.8634
p.R373W	DO51734	COAD	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation altering degron motif	0.8634
p.P776L	DO9106	COAD	ICGC	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.25
p.G828A	DO8898	COAD	ICGC	VSSST	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.1389
p.R382H	DO227549	COCA	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.2778
p.S785Y	DO222762	COCA	ICGC	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation altering degron motif	0.6009
p.T826M	DO222794	COCA	ICGC	VSSST	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.0833
p.P884L	DO234389	ESAD	ICGC	PATTPTGS	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.2778
p.T878M	DO233903	GACA	ICGC	PATTPTGS	DEG_SCF_FBW7_1	875:882	Mutation altering degron motif	0.7423
p.P381S	DO224715	LAML	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.3056
p.S368C	DO228827	LICA	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.2222
p.A470S	DO228948	LICA	ICGC	VPTSS	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.3056
p.A470S	DO228948	LICA	ICGC	PVTSS	DEG_SPOP_SBC_1	479:483	Mutation rewiring degron network	0.0833
p.G372C	DO228986	LICA	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation altering degron motif	0.6489
p.A781S	DO229018	LICA	ICGC	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation altering degron motif	0.6477
p.G375V	DO229015	LICA	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation altering degron motif	0.6421
p.A865S	DO229026	LICA	ICGC	PATTPTGS	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.0556
p.V489M	DO229052	LICA	ICGC	PVTSS	DEG_SPOP_SBC_1	479:483	Mutation rewiring degron network	0.1667
p.S491Y	DO229052	LICA	ICGC	PVTSS	DEG_SPOP_SBC_1	479:483	Mutation blocking phosphorylation signal	0.5556
p.P848L	DO229054	LICA	ICGC	VSSST	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.0833
p.G490D	DO23290	LINC	ICGC	PVTSS	DEG_SPOP_SBC_1	479:483	Mutation rewiring degron network	0.1389
p.G372S	DO231072	LUSC	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation altering degron motif	0.5882
p.F795L	DO220899	MELA	ICGC	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.0833
p.S378F	DO222557	MELA	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation altering degron motif	0.6871
p.S786F	DO222714	MELA	ICGC	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation altering degron motif	0.7982
p.G488E	DO232224	PBCA	ICGC	PVTSS	DEG_SPOP_SBC_1	479:483	Mutation rewiring degron network	0.1944
p.P792H	SIDM02021	Esophageal Carcinoma	GDSC	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.1667
p.S482L	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PVTSS	DEG_SPOP_SBC_1	479:483	Mutation altering degron motif	0.7667
p.S482L	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PVTSS	DEG_SPOP_SBC_1	479:483	Mutation altering degron motif	0.7667
p.S844A	SIDM00845	Burkitt's Lymphoma	GDSC	VSSST	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.1944
p.V484L	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VPTSS	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.0833
p.V484L	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PVTSS	DEG_SPOP_SBC_1	479:483	Mutation rewiring degron network	0.3056
p.V484L	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VPTSS	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.0833
p.V484L	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PVTSS	DEG_SPOP_SBC_1	479:483	Mutation rewiring degron network	0.3056
p.Q793E	SIDM00240	Cervical Carcinoma	GDSC	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.1389
p.Q793E	OMC-1	cervix	COSMIC	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.1389
p.H386L	SIDM01187	Breast Carcinoma	GDSC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.1667
p.H386L	ACH-000568	Breast Cancer	CCLE	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.1667
p.H386L	UACC-812	breast	COSMIC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation rewiring degron network	0.1667
p.A780V	SIDM00901	Endometrial Carcinoma	GDSC	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation altering degron motif	0.5825
p.A780V	AN3-CA	endometrium	COSMIC	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation altering degron motif	0.5825
p.Q841R	SIDM00901	Endometrial Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.2778
p.Q841R	AN3-CA	endometrium	COSMIC	VSSST	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.2778
p.P772S	ACH-000940	Endometrial/Uterine Cancer	CCLE	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.1389
p.P772S	AN3-CA	endometrium	COSMIC	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.1389
p.A786V	ACH-000940	Endometrial/Uterine Cancer	CCLE	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation altering degron motif	0.6936
p.A786V	AN3-CA	endometrium	COSMIC	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation altering degron motif	0.6936
p.Q847R	ACH-000940	Endometrial/Uterine Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.1111
p.Q847R	AN3-CA	endometrium	COSMIC	VSSST	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.1111
p.S488L	ACH-000983	Leukemia	CCLE	PVTSS	DEG_SPOP_SBC_1	479:483	Mutation rewiring degron network	0.1944
p.S488L	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PVTSS	DEG_SPOP_SBC_1	479:483	Mutation rewiring degron network	0.1944
p.S866F	ACH-000987	Skin Cancer	CCLE	PATTPTGS	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.0833
p.P828T	ACH-001068	Lymphoma	CCLE	VSSST	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.1389
p.V471G	SK-NEP-1	kidney	COSMIC	VPTSS	DEG_SPOP_SBC_1	471:475	Mutation altering degron motif	0.7532
p.V477G	SK-NEP-1	kidney	COSMIC	VPTSS	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.2778
p.V477G	SK-NEP-1	kidney	COSMIC	PVTSS	DEG_SPOP_SBC_1	479:483	Mutation rewiring degron network	0.2778
p.R829H	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VSSST	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.1667
p.A770P	CP66-MEL	skin	COSMIC	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.0833
p.V490L	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PVTSS	DEG_SPOP_SBC_1	479:483	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATXN2L

UniProt ID: Q8WWM7

Entrez ID: 11273

Protein name: Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATXN2L in