DegronMD - Q8WWM7(ATXN2L)

FUNCTION: Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}.

GO - Biological processes (BP): mRNA metabolic process [GO:0016071]; stress granule assembly [GO:0034063]

GO - Molecular function (MF): cadherin binding [GO:0045296]; RNA binding [GO:0003723]

GO - Cellular component (CC): cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
GRPGLSSLP	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Ataxin-2-like protein	372:380	More..
VAATPYSS	DEG_SCF_FBW7_1	FBXW7	Ataxin-2-like protein	779:786	More..
PATTPTGS	DEG_SCF_FBW7_1	FBXW7	Ataxin-2-like protein	875:882	More..
VPTSS	DEG_SPOP_SBC_1	SPOP	Ataxin-2-like protein	471:475	More..
PVTSS	DEG_SPOP_SBC_1	SPOP	Ataxin-2-like protein	479:483	More..
VSSST	DEG_SPOP_SBC_1	SPOP	Ataxin-2-like protein	835:839	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R373W	TCGA-WS-AB45	COAD	TCGA	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation altering degron motif	0.8634
p.R373W	DO51734	COAD	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation altering degron motif	0.8634
p.S786F	DO222714	MELA	ICGC	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation altering degron motif	0.7982
p.P479H	TCGA-EE-A3AC	SKCM	TCGA	PVTSS	DEG_SPOP_SBC_1	479:483	Mutation altering degron motif	0.7694
p.P479H	DO37631	SKCM	ICGC	PVTSS	DEG_SPOP_SBC_1	479:483	Mutation altering degron motif	0.7694
p.P879H	TCGA-FI-A2D5	UCEC	TCGA	PATTPTGS	DEG_SCF_FBW7_1	875:882	Mutation altering degron motif	0.7694
p.P879H	DO41331	UCEC	ICGC	PATTPTGS	DEG_SCF_FBW7_1	875:882	Mutation altering degron motif	0.7694
p.S482L	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PVTSS	DEG_SPOP_SBC_1	479:483	Mutation altering degron motif	0.7667
p.S482L	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PVTSS	DEG_SPOP_SBC_1	479:483	Mutation altering degron motif	0.7667
p.V471G	SK-NEP-1	kidney	COSMIC	VPTSS	DEG_SPOP_SBC_1	471:475	Mutation altering degron motif	0.7532
p.P783A	TCGA-13-0893	OV	TCGA	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation altering degron motif	0.7503
p.P783A	DO29002	OV	ICGC	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation altering degron motif	0.7503
p.T878M	DO233903	GACA	ICGC	PATTPTGS	DEG_SCF_FBW7_1	875:882	Mutation altering degron motif	0.7423
p.A786V	ACH-000940	Endometrial/Uterine Cancer	CCLE	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation altering degron motif	0.6936
p.A786V	AN3-CA	endometrium	COSMIC	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation altering degron motif	0.6936
p.S378F	DO222557	MELA	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation altering degron motif	0.6871
p.G372C	DO228986	LICA	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation altering degron motif	0.6489
p.A781S	DO229018	LICA	ICGC	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation altering degron motif	0.6477
p.G375V	DO229015	LICA	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	372:380	Mutation altering degron motif	0.6421
p.S785Y	DO222762	COCA	ICGC	VAATPYSS	DEG_SCF_FBW7_1	779:786	Mutation altering degron motif	0.6009

Showing 1 to 20 of 117 entries

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No resistance data available for this Degron.

Kaplan plot for ATXN2L in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATXN2L

UniProt ID: Q8WWM7

Entrez ID: 11273

Protein name: Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for ATXN2L in