DegronMD

Uniprot ID: Q8WWM7

Source protein: Ataxin-2-like protein

Source gene: ATXN2L

Class: DEG_SCF_FBW7_1

Location: 779:786

E3 ligase: FBXW7

DEGRON score: 0.9822

ASA_SCORE: 77.45

COIL: 0.9335

CONS_SCORE: 0.2959

DSS_SCORE: 0.3146

HELIX: 0.0338

FCONS_SCORE: 0.8153

RIG_SCORE: 0.6954

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P783A	TCGA-13-0893	OV	TCGA	VAATPYSS	DEG_SCF_FBW7_1	0.7503
p.P783A	DO29002	OV	ICGC	VAATPYSS	DEG_SCF_FBW7_1	0.7503
p.A772V	TCGA-2W-A8YY	CESC	TCGA	VAATPYSS	DEG_SCF_FBW7_1	0.1389
p.A772V	DO223732	CESC	ICGC	VAATPYSS	DEG_SCF_FBW7_1	0.1389
p.P792S	TCGA-QG-A5Z2	COAD	TCGA	VAATPYSS	DEG_SCF_FBW7_1	0.1667
p.P792S	DO44096	COAD	ICGC	VAATPYSS	DEG_SCF_FBW7_1	0.1667
p.P776L	DO9106	COAD	ICGC	VAATPYSS	DEG_SCF_FBW7_1	0.25
p.S785Y	DO222762	COCA	ICGC	VAATPYSS	DEG_SCF_FBW7_1	0.6009
p.A781S	DO229018	LICA	ICGC	VAATPYSS	DEG_SCF_FBW7_1	0.6477
p.F795L	DO220899	MELA	ICGC	VAATPYSS	DEG_SCF_FBW7_1	0.0833
p.S786F	DO222714	MELA	ICGC	VAATPYSS	DEG_SCF_FBW7_1	0.7982
p.P792H	SIDM02021	Esophageal Carcinoma	GDSC	VAATPYSS	DEG_SCF_FBW7_1	0.1667
p.Q793E	SIDM00240	Cervical Carcinoma	GDSC	VAATPYSS	DEG_SCF_FBW7_1	0.1389
p.Q793E	OMC-1	cervix	COSMIC	VAATPYSS	DEG_SCF_FBW7_1	0.1389
p.A780V	SIDM00901	Endometrial Carcinoma	GDSC	VAATPYSS	DEG_SCF_FBW7_1	0.5825
p.A780V	AN3-CA	endometrium	COSMIC	VAATPYSS	DEG_SCF_FBW7_1	0.5825
p.P772S	ACH-000940	Endometrial/Uterine Cancer	CCLE	VAATPYSS	DEG_SCF_FBW7_1	0.1389
p.P772S	AN3-CA	endometrium	COSMIC	VAATPYSS	DEG_SCF_FBW7_1	0.1389
p.A786V	ACH-000940	Endometrial/Uterine Cancer	CCLE	VAATPYSS	DEG_SCF_FBW7_1	0.6936
p.A786V	AN3-CA	endometrium	COSMIC	VAATPYSS	DEG_SCF_FBW7_1	0.6936
p.A770P	CP66-MEL	skin	COSMIC	VAATPYSS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWM7	Ataxin-2-like protein	DEG_SCF_FBW7_1	779:786	VAATPYSS	FBXW7	0.9822	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons