DegronMD

Uniprot ID: Q8WWM7

Source protein: Ataxin-2-like protein

Source gene: ATXN2L

Class: DEG_APCC_DBOX_1

Location: 372:380

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9814

ASA_SCORE: 89.9444

COIL: 0.9703

CONS_SCORE: 0.3003

DSS_SCORE: 0.7621

HELIX: 0.0114

FCONS_SCORE: 1.0253

RIG_SCORE: 0.5117

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R365G	TCGA-22-A5C4	LUSC	TCGA	GRPGLSSLP	DEG_APCC_DBOX_1	0.1389
p.R365G	DO45446	LUSC	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	0.1389
p.R382C	TCGA-66-2791	LUSC	TCGA	GRPGLSSLP	DEG_APCC_DBOX_1	0.2778
p.R382C	TCGA-86-8056	LUAD	TCGA	GRPGLSSLP	DEG_APCC_DBOX_1	0.2778
p.R382C	TCGA-H7-8501	HNSC	TCGA	GRPGLSSLP	DEG_APCC_DBOX_1	0.2778
p.R382C	TCGA-XF-A9T0	BLCA	TCGA	GRPGLSSLP	DEG_APCC_DBOX_1	0.2778
p.R382C	DO48401	BLCA	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	0.2778
p.R382C	DO48457	BLCA	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	0.2778
p.R382C	DO51920	BLCA	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	0.2778
p.R382C	DO222744	ESCA	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	0.2778
p.R382C	DO14202	HNSC	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	0.2778
p.R382C	DO24950	LUAD	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	0.2778
p.R382C	DO26435	LUSC	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	0.2778
p.G362V	TCGA-85-8287	LUSC	TCGA	GRPGLSSLP	DEG_APCC_DBOX_1	0.0556
p.G362V	DO27492	LUSC	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	0.0556
p.G371D	TCGA-BH-A0HX	BRCA	TCGA	GRPGLSSLP	DEG_APCC_DBOX_1	0.3056
p.G371D	DO5891	BRCA	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	0.3056
p.H386Y	TCGA-EE-A2GC	SKCM	TCGA	GRPGLSSLP	DEG_APCC_DBOX_1	0.1667
p.H386Y	DO222749	MELA	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	0.1667
p.H386Y	DO37839	SKCM	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	0.1667
p.S369A	TCGA-GN-A26C	SKCM	TCGA	GRPGLSSLP	DEG_APCC_DBOX_1	0.25
p.S369A	DO37782	SKCM	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	0.25
p.S369F	TCGA-GN-A26C	SKCM	TCGA	GRPGLSSLP	DEG_APCC_DBOX_1	0.25
p.S369F	DO37782	SKCM	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	0.25
p.G363R	TCGA-QK-A8Z8	HNSC	TCGA	GRPGLSSLP	DEG_APCC_DBOX_1	0.0833
p.G363R	DO52097	HNSC	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	0.0833
p.R373W	TCGA-WS-AB45	COAD	TCGA	GRPGLSSLP	DEG_APCC_DBOX_1	0.8634
p.R373W	DO51734	COAD	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	0.8634
p.R382H	DO227549	COCA	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	0.2778
p.P381S	DO224715	LAML	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	0.3056
p.S368C	DO228827	LICA	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	0.2222
p.G372C	DO228986	LICA	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	0.6489
p.G375V	DO229015	LICA	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	0.6421
p.G372S	DO231072	LUSC	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	0.5882
p.S378F	DO222557	MELA	ICGC	GRPGLSSLP	DEG_APCC_DBOX_1	0.6871
p.H386L	SIDM01187	Breast Carcinoma	GDSC	GRPGLSSLP	DEG_APCC_DBOX_1	0.1667
p.H386L	ACH-000568	Breast Cancer	CCLE	GRPGLSSLP	DEG_APCC_DBOX_1	0.1667
p.H386L	UACC-812	breast	COSMIC	GRPGLSSLP	DEG_APCC_DBOX_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRPGLSSLP

Degron related mutations and impact score

Drug responses associated with ATXN2L mutations

All proteins holding degron of GRPGLSSLP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWM7	Ataxin-2-like protein	DEG_APCC_DBOX_1	372:380	GRPGLSSLP	APC,CDC20,FZR1	0.9814	More...