DegronMD

Uniprot ID: Q8WWM7

Source protein: Ataxin-2-like protein

Source gene: ATXN2L

Class: DEG_SPOP_SBC_1

Location: 471:475

E3 ligase: SPOP

DEGRON score: 0.9372

ASA_SCORE: 86.52

COIL: 0.9356

CONS_SCORE: 0.2823

DSS_SCORE: 0.4915

HELIX: 0.046

FCONS_SCORE: 0.8608

RIG_SCORE: 0.6244

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P466S	TCGA-CR-7404	HNSC	TCGA	VPTSS	DEG_SPOP_SBC_1	0.1944
p.P466S	DO14420	HNSC	ICGC	VPTSS	DEG_SPOP_SBC_1	0.1944
p.G468S	TCGA-KK-A59V	PRAD	TCGA	VPTSS	DEG_SPOP_SBC_1	0.25
p.G468S	DO51346	PRAD	ICGC	VPTSS	DEG_SPOP_SBC_1	0.25
p.A470S	DO228948	LICA	ICGC	VPTSS	DEG_SPOP_SBC_1	0.3056
p.V484L	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VPTSS	DEG_SPOP_SBC_1	0.0833
p.V484L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VPTSS	DEG_SPOP_SBC_1	0.0833
p.V471G	SK-NEP-1	kidney	COSMIC	VPTSS	DEG_SPOP_SBC_1	0.7532
p.V477G	SK-NEP-1	kidney	COSMIC	VPTSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75038	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2	DEG_SPOP_SBC_1	1022:1026	VPTSS	SPOP	0.7337	More...
O75604	Ubiquitin carboxyl-terminal hydrolase 2	DEG_SPOP_SBC_1	54:58	VPTSS	SPOP	0.9881	More...
O94850	Dendrin	DEG_SPOP_SBC_1	251:255	VPTSS	SPOP	0.9712	More...
P22307	Sterol carrier protein 2	DEG_SPOP_SBC_1	422:426	VPTSS	SPOP	0.6008	More...
P31629	Transcription factor HIVEP2	DEG_SPOP_SBC_1	546:550	VPTSS	SPOP	0.9975	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2863:2867	VPTSS	SPOP	0.9646	More...
Q01973	Inactive tyrosine-protein kinase transmembrane receptor ROR1	DEG_SPOP_SBC_1	41:45	VPTSS	SPOP	0.8246	More...
Q02447	Transcription factor Sp3	DEG_SPOP_SBC_1	331:335	VPTSS	SPOP	0.9924	More...
Q8WWM7	Ataxin-2-like protein	DEG_SPOP_SBC_1	471:475	VPTSS	SPOP	0.9372	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12511:12515	VPTSS	SPOP	0.96	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12667:12671	VPTSS	SPOP	0.9914	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	1602:1606	VPTSS	SPOP	0.9498	More...
P60413	Keratin-associated protein 10-12	DEG_SPOP_SBC_1	216:220	VPTSS	SPOP	0.7395	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	927:931	VPTSS	SPOP	0.8818	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons