DegronMD

Uniprot ID: O75604

Source protein: Ubiquitin carboxyl-terminal hydrolase 2

Source gene: USP2

Class: DEG_SPOP_SBC_1

Location: 54:58

E3 ligase: SPOP

DEGRON score: 0.9881

ASA_SCORE: 74.64

COIL: 0.8506

CONS_SCORE: 0.387

DSS_SCORE: 0.4152

HELIX: 0.1418

FCONS_SCORE: 1.022

RIG_SCORE: 0.7337

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y66C	TCGA-BR-A4CS	STAD	TCGA	VPTSS	DEG_SPOP_SBC_1	0.1111
p.Y66C	DO47965	STAD	ICGC	VPTSS	DEG_SPOP_SBC_1	0.1111
p.R64S	TCGA-CC-A8HV	LIHC	TCGA	VPTSS	DEG_SPOP_SBC_1	0.1667
p.R64S	DO52189	LIHC	ICGC	VPTSS	DEG_SPOP_SBC_1	0.1667
p.T61A	TCGA-VQ-A8PX	STAD	TCGA	VPTSS	DEG_SPOP_SBC_1	0.25
p.T61A	DO51778	STAD	ICGC	VPTSS	DEG_SPOP_SBC_1	0.25
p.E45Q	DO22804	LICA	ICGC	VPTSS	DEG_SPOP_SBC_1	0.0833
p.R49K	DO219121	LUSC	ICGC	VPTSS	DEG_SPOP_SBC_1	0.1944
p.P53L	SIDM01112	Osteosarcoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.3056
p.P53L	SIDM00863	Burkitt's Lymphoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.3056
p.R62H	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.2222
p.R62H	ACH-000980	Lung Cancer	CCLE	VPTSS	DEG_SPOP_SBC_1	0.2222
p.R62H	NCI-H1155	lung	COSMIC	VPTSS	DEG_SPOP_SBC_1	0.2222
p.G67R	SIDM00276	Biliary Tract Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.0833
p.G67R	ETK-1	biliary_tract	COSMIC	VPTSS	DEG_SPOP_SBC_1	0.0833
p.F59V	ACH-000993	Endometrial/Uterine Cancer	CCLE	VPTSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75038	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2	DEG_SPOP_SBC_1	1022:1026	VPTSS	SPOP	0.7337	More...
O75604	Ubiquitin carboxyl-terminal hydrolase 2	DEG_SPOP_SBC_1	54:58	VPTSS	SPOP	0.9881	More...
O94850	Dendrin	DEG_SPOP_SBC_1	251:255	VPTSS	SPOP	0.9712	More...
P22307	Sterol carrier protein 2	DEG_SPOP_SBC_1	422:426	VPTSS	SPOP	0.6008	More...
P31629	Transcription factor HIVEP2	DEG_SPOP_SBC_1	546:550	VPTSS	SPOP	0.9975	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2863:2867	VPTSS	SPOP	0.9646	More...
Q01973	Inactive tyrosine-protein kinase transmembrane receptor ROR1	DEG_SPOP_SBC_1	41:45	VPTSS	SPOP	0.8246	More...
Q02447	Transcription factor Sp3	DEG_SPOP_SBC_1	331:335	VPTSS	SPOP	0.9924	More...
Q8WWM7	Ataxin-2-like protein	DEG_SPOP_SBC_1	471:475	VPTSS	SPOP	0.9372	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12511:12515	VPTSS	SPOP	0.96	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12667:12671	VPTSS	SPOP	0.9914	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	1602:1606	VPTSS	SPOP	0.9498	More...
P60413	Keratin-associated protein 10-12	DEG_SPOP_SBC_1	216:220	VPTSS	SPOP	0.7395	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	927:931	VPTSS	SPOP	0.8818	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons