DegronMD

Uniprot ID: P60413

Source protein: Keratin-associated protein 10-12

Source gene: KRTAP10-12

Class: DEG_SPOP_SBC_1

Location: 216:220

E3 ligase: SPOP

DEGRON score: 0.7395

ASA_SCORE: 79.86

COIL: 0.888

CONS_SCORE: 0.5245

DSS_SCORE: 0.0042

HELIX: 0.0162

FCONS_SCORE: 0.7482

RIG_SCORE: 0.7627

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R207H	TCGA-12-3646	GBM	TCGA	VPTSS	DEG_SPOP_SBC_1	0.0833
p.R207H	DO12184	GBM	ICGC	VPTSS	DEG_SPOP_SBC_1	0.0833
p.R207C	TCGA-DU-5849	LGG	TCGA	VPTSS	DEG_SPOP_SBC_1	0.0833
p.R207C	DO22270	LGG	ICGC	VPTSS	DEG_SPOP_SBC_1	0.0833
p.R208H	TCGA-IB-7651	PAAD	TCGA	VPTSS	DEG_SPOP_SBC_1	0.1111
p.R208H	DO46657	PAAD	ICGC	VPTSS	DEG_SPOP_SBC_1	0.1111
p.G226S	DO227999	COCA	ICGC	VPTSS	DEG_SPOP_SBC_1	0.1667
p.G226S	DO229003	COCA	ICGC	VPTSS	DEG_SPOP_SBC_1	0.1667
p.G226S	DO230659	LAML	ICGC	VPTSS	DEG_SPOP_SBC_1	0.1667
p.G226S	DO231140	LAML	ICGC	VPTSS	DEG_SPOP_SBC_1	0.1667
p.G226S	DO228947	LICA	ICGC	VPTSS	DEG_SPOP_SBC_1	0.1667
p.G226S	DO230550	LUSC	ICGC	VPTSS	DEG_SPOP_SBC_1	0.1667
p.T218P	DO46478	OV	ICGC	VPTSS	DEG_SPOP_SBC_1	0.7031
p.R208C	SIDM00803	Kidney Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.1111
p.R208C	769-P	kidney	COSMIC	VPTSS	DEG_SPOP_SBC_1	0.1111
p.R227L	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.1389
p.R227L	ACH-000878	Lung Cancer	CCLE	VPTSS	DEG_SPOP_SBC_1	0.1389
p.R227L	HCC-15	lung	COSMIC	VPTSS	DEG_SPOP_SBC_1	0.1389
p.L228Q	SIDM01608	Endometrial Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.1111
p.L228Q	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.1111
p.L228Q	ACH-000553	Lung Cancer	CCLE	VPTSS	DEG_SPOP_SBC_1	0.1111
p.L228Q	ACH-000990	Endometrial/Uterine Cancer	CCLE	VPTSS	DEG_SPOP_SBC_1	0.1111
p.P223S	ACH-001450	Lymphoma	CCLE	VPTSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75038	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2	DEG_SPOP_SBC_1	1022:1026	VPTSS	SPOP	0.7337	More...
O75604	Ubiquitin carboxyl-terminal hydrolase 2	DEG_SPOP_SBC_1	54:58	VPTSS	SPOP	0.9881	More...
O94850	Dendrin	DEG_SPOP_SBC_1	251:255	VPTSS	SPOP	0.9712	More...
P22307	Sterol carrier protein 2	DEG_SPOP_SBC_1	422:426	VPTSS	SPOP	0.6008	More...
P31629	Transcription factor HIVEP2	DEG_SPOP_SBC_1	546:550	VPTSS	SPOP	0.9975	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2863:2867	VPTSS	SPOP	0.9646	More...
Q01973	Inactive tyrosine-protein kinase transmembrane receptor ROR1	DEG_SPOP_SBC_1	41:45	VPTSS	SPOP	0.8246	More...
Q02447	Transcription factor Sp3	DEG_SPOP_SBC_1	331:335	VPTSS	SPOP	0.9924	More...
Q8WWM7	Ataxin-2-like protein	DEG_SPOP_SBC_1	471:475	VPTSS	SPOP	0.9372	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12511:12515	VPTSS	SPOP	0.96	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12667:12671	VPTSS	SPOP	0.9914	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	1602:1606	VPTSS	SPOP	0.9498	More...
P60413	Keratin-associated protein 10-12	DEG_SPOP_SBC_1	216:220	VPTSS	SPOP	0.7395	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	927:931	VPTSS	SPOP	0.8818	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons