DegronMD - P31629(HIVEP2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1581G	TCGA-2G-AAGP	TGCT	TCGA	PQSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.3056
p.P474T	TCGA-2W-A8YY	CESC	TCGA	VKMFED	LIG_APCC_ABBA_1	468:473	Mutation rewiring degron network	0.3056
p.P474T	DO223732	CESC	ICGC	VKMFED	LIG_APCC_ABBA_1	468:473	Mutation rewiring degron network	0.3056
p.S476L	TCGA-4Z-AA7M	BLCA	TCGA	VKMFED	LIG_APCC_ABBA_1	468:473	Mutation rewiring degron network	0.25
p.S476L	DO218976	BLCA	ICGC	VKMFED	LIG_APCC_ABBA_1	468:473	Mutation rewiring degron network	0.25
p.R431W	TCGA-66-2744	LUSC	TCGA	VTTTS	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.0833
p.R431W	TCGA-XK-AAIW	PRAD	TCGA	VTTTS	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.0833
p.R431W	DO27025	LUSC	ICGC	VTTTS	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.0833
p.R431W	DO51407	PRAD	ICGC	VTTTS	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.0833
p.R431W	SIDM00217	Colorectal Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.0833
p.R431W	ACH-000999	Colon/Colorectal Cancer	CCLE	VTTTS	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.0833
p.R431W	SNU-1040	large intestine	COSMIC	VTTTS	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.0833
p.T1195A	TCGA-78-7146	LUAD	TCGA	LFPHQE	LIG_APCC_ABBA_1	1189:1194	Mutation rewiring degron network	0.3056
p.T1195A	DO23717	LUAD	ICGC	LFPHQE	LIG_APCC_ABBA_1	1189:1194	Mutation rewiring degron network	0.3056
p.E1194Q	TCGA-86-6851	LUAD	TCGA	LFPHQE	LIG_APCC_ABBA_1	1189:1194	Mutation altering degron motif	0.6744
p.E1194Q	TCGA-98-8021	LUSC	TCGA	LFPHQE	LIG_APCC_ABBA_1	1189:1194	Mutation altering degron motif	0.6744
p.E1194Q	DO23798	LUAD	ICGC	LFPHQE	LIG_APCC_ABBA_1	1189:1194	Mutation altering degron motif	0.6744
p.E1194Q	DO27468	LUSC	ICGC	LFPHQE	LIG_APCC_ABBA_1	1189:1194	Mutation altering degron motif	0.6744
p.R2091K	TCGA-92-7340	LUSC	TCGA	PRRDLSPMR	DEG_APCC_DBOX_1	2078:2086	Mutation rewiring degron network	0.1944
p.R2091K	DO26775	LUSC	ICGC	PRRDLSPMR	DEG_APCC_DBOX_1	2078:2086	Mutation rewiring degron network	0.1944
p.Q1583H	TCGA-98-8021	LUSC	TCGA	PQSSS	DEG_SPOP_SBC_1	1582:1586	Mutation altering degron motif	0.647
p.Q1583H	DO27468	LUSC	ICGC	PQSSS	DEG_SPOP_SBC_1	1582:1586	Mutation altering degron motif	0.647
p.P2182S	TCGA-98-A53J	LUSC	TCGA	FSLYGD	LIG_APCC_ABBA_1	2184:2189	Mutation rewiring degron network	0.2778
p.P2182S	DO219183	LUSC	ICGC	FSLYGD	LIG_APCC_ABBA_1	2184:2189	Mutation rewiring degron network	0.2778
p.R1979Q	TCGA-A5-A2K5	UCEC	TCGA	LMTPSDS	DEG_SCF_FBW7_1	1983:1989	Mutation rewiring degron network	0.2222
p.R1979Q	TCGA-ND-A4WC	UCS	TCGA	LMTPSDS	DEG_SCF_FBW7_1	1983:1989	Mutation rewiring degron network	0.2222
p.R1979Q	DO41379	UCEC	ICGC	LMTPSDS	DEG_SCF_FBW7_1	1983:1989	Mutation rewiring degron network	0.2222
p.R1979Q	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	LMTPSDS	DEG_SCF_FBW7_1	1983:1989	Mutation rewiring degron network	0.2222
p.R1979Q	ACH-000980	Lung Cancer	CCLE	LMTPSDS	DEG_SCF_FBW7_1	1983:1989	Mutation rewiring degron network	0.2222
p.R1979Q	NCI-H1155	lung	COSMIC	LMTPSDS	DEG_SCF_FBW7_1	1983:1989	Mutation rewiring degron network	0.2222
p.G2192D	TCGA-A7-A3RF	BRCA	TCGA	FSLYGD	LIG_APCC_ABBA_1	2184:2189	Mutation rewiring degron network	0.25
p.G2192D	TCGA-AZ-4614	COAD	TCGA	FSLYGD	LIG_APCC_ABBA_1	2184:2189	Mutation rewiring degron network	0.25
p.G2192D	DO5583	BRCA	ICGC	FSLYGD	LIG_APCC_ABBA_1	2184:2189	Mutation rewiring degron network	0.25
p.G2192D	DO10012	COAD	ICGC	FSLYGD	LIG_APCC_ABBA_1	2184:2189	Mutation rewiring degron network	0.25
p.S1585Y	TCGA-AA-3510	COAD	TCGA	PQSSS	DEG_SPOP_SBC_1	1582:1586	Mutation altering degron motif	0.712
p.S1585Y	DO7783	COAD	ICGC	PQSSS	DEG_SPOP_SBC_1	1582:1586	Mutation altering degron motif	0.712
p.S559Y	TCGA-AG-A002	READ	TCGA	VPTSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.0833
p.F401L	TCGA-AP-A0LM	UCEC	TCGA	DSGYFS	DEG_SCF_TRCP1_1	397:402	Mutation altering degron motif	0.587
p.F401L	TCGA-E6-A1LX	UCEC	TCGA	DSGYFS	DEG_SCF_TRCP1_1	397:402	Mutation altering degron motif	0.587
p.F401L	DO43306	UCEC	ICGC	DSGYFS	DEG_SCF_TRCP1_1	397:402	Mutation altering degron motif	0.587
p.F401L	DO41020	UCEC	ICGC	DSGYFS	DEG_SCF_TRCP1_1	397:402	Mutation altering degron motif	0.587
p.L2088I	TCGA-AP-A1DV	UCEC	TCGA	PRRDLSPMR	DEG_APCC_DBOX_1	2078:2086	Mutation rewiring degron network	0.2778
p.L2088I	DO43186	UCEC	ICGC	PRRDLSPMR	DEG_APCC_DBOX_1	2078:2086	Mutation rewiring degron network	0.2778
p.R447C	TCGA-AX-A1CE	UCEC	TCGA	VTTTS	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.25
p.R447C	DO42280	UCEC	ICGC	VTTTS	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.25
p.R447C	ACH-001147	Lymphoma	CCLE	VTTTS	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.25
p.D259Y	TCGA-B0-4698	KIRC	TCGA	LVPFTE	LIG_APCC_ABBA_1	247:252	Mutation rewiring degron network	0.1389
p.D259Y	DO20368	KIRC	ICGC	LVPFTE	LIG_APCC_ABBA_1	247:252	Mutation rewiring degron network	0.1389
p.S545P	TCGA-B5-A11E	UCEC	TCGA	VPTSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.3056
p.S545P	DO41644	UCEC	ICGC	VPTSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.3056
p.S2089P	TCGA-B5-A3FA	UCEC	TCGA	PRRDLSPMR	DEG_APCC_DBOX_1	2078:2086	Mutation rewiring degron network	0.25
p.S2089P	DO52402	UCEC	ICGC	PRRDLSPMR	DEG_APCC_DBOX_1	2078:2086	Mutation rewiring degron network	0.25
p.P1200L	TCGA-CV-7568	HNSC	TCGA	LFPHQE	LIG_APCC_ABBA_1	1189:1194	Mutation rewiring degron network	0.1667
p.P1200L	DO14160	HNSC	ICGC	LFPHQE	LIG_APCC_ABBA_1	1189:1194	Mutation rewiring degron network	0.1667
p.R542K	TCGA-D3-A51T	SKCM	TCGA	VPTSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.2222
p.R542K	DO47389	SKCM	ICGC	VPTSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.2222
p.F401S	TCGA-DF-A2KU	UCEC	TCGA	DSGYFS	DEG_SCF_TRCP1_1	397:402	Mutation altering degron motif	0.6871
p.F401S	DO223286	UCEC	ICGC	DSGYFS	DEG_SCF_TRCP1_1	397:402	Mutation altering degron motif	0.6871
p.D1591N	TCGA-DK-A6B6	BLCA	TCGA	PQSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.1944
p.D1591N	DO48576	BLCA	ICGC	PQSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.1944
p.S398F	TCGA-DU-6392	LGG	TCGA	DSGYFS	DEG_SCF_TRCP1_1	397:402	Mutation altering degron motif	0.7982
p.S398F	DO22237	LGG	ICGC	DSGYFS	DEG_SCF_TRCP1_1	397:402	Mutation altering degron motif	0.7982
p.P1588S	TCGA-EE-A29V	SKCM	TCGA	PQSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.2778
p.P1588S	DO38006	SKCM	ICGC	PQSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.2778
p.G2198D	TCGA-EK-A3GK	CESC	TCGA	FSLYGD	LIG_APCC_ABBA_1	2184:2189	Mutation rewiring degron network	0.0833
p.G2198D	DO49964	CESC	ICGC	FSLYGD	LIG_APCC_ABBA_1	2184:2189	Mutation rewiring degron network	0.0833
p.P1986L	TCGA-EO-A22U	UCEC	TCGA	LMTPSDS	DEG_SCF_FBW7_1	1983:1989	Mutation altering degron motif	0.7582
p.P1986L	DO43755	UCEC	ICGC	LMTPSDS	DEG_SCF_FBW7_1	1983:1989	Mutation altering degron motif	0.7582
p.H1192Q	TCGA-EO-A22X	UCEC	TCGA	LFPHQE	LIG_APCC_ABBA_1	1189:1194	Mutation altering degron motif	0.7582
p.H1192Q	DO43907	UCEC	ICGC	LFPHQE	LIG_APCC_ABBA_1	1189:1194	Mutation altering degron motif	0.7582
p.P474H	TCGA-EO-A3KX	UCEC	TCGA	VKMFED	LIG_APCC_ABBA_1	468:473	Mutation rewiring degron network	0.3056
p.P474H	DO219774	UCEC	ICGC	VKMFED	LIG_APCC_ABBA_1	468:473	Mutation rewiring degron network	0.3056
p.S2185G	TCGA-FI-A2D0	UCEC	TCGA	FSLYGD	LIG_APCC_ABBA_1	2184:2189	Mutation altering degron motif	0.5882
p.S2185G	DO43891	UCEC	ICGC	FSLYGD	LIG_APCC_ABBA_1	2184:2189	Mutation altering degron motif	0.5882
p.T1985A	TCGA-FI-A2D5	UCEC	TCGA	LMTPSDS	DEG_SCF_FBW7_1	1983:1989	Mutation altering degron motif	0.825
p.T1985A	DO41331	UCEC	ICGC	LMTPSDS	DEG_SCF_FBW7_1	1983:1989	Mutation altering degron motif	0.825
p.D473V	TCGA-FR-A8YC	SKCM	TCGA	VKMFED	LIG_APCC_ABBA_1	468:473	Mutation altering degron motif	0.7785
p.D473V	DO50301	SKCM	ICGC	VKMFED	LIG_APCC_ABBA_1	468:473	Mutation altering degron motif	0.7785
p.T1574A	TCGA-HU-A4H4	STAD	TCGA	PQSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.1111
p.T1574A	DO47721	STAD	ICGC	PQSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.1111
p.E1596Q	TCGA-K4-A54R	BLCA	TCGA	PQSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.0556
p.E1596Q	DO48611	BLCA	ICGC	PQSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.0556
p.Q1202R	TCGA-L9-A743	LUAD	TCGA	LFPHQE	LIG_APCC_ABBA_1	1189:1194	Mutation rewiring degron network	0.1111
p.Q1202R	DO49874	LUAD	ICGC	LFPHQE	LIG_APCC_ABBA_1	1189:1194	Mutation rewiring degron network	0.1111
p.Q1193E	TCGA-MA-AA3Y	CESC	TCGA	LFPHQE	LIG_APCC_ABBA_1	1189:1194	Mutation altering degron motif	0.5633
p.Q1193E	DO219721	CESC	ICGC	LFPHQE	LIG_APCC_ABBA_1	1189:1194	Mutation altering degron motif	0.5633
p.S559F	TCGA-QQ-A5VD	SARC	TCGA	VPTSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.0833
p.S559F	DO220252	SARC	ICGC	VPTSS	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.0833
p.E408K	TCGA-UY-A9PE	BLCA	TCGA	DSGYFS	DEG_SCF_TRCP1_1	397:402	Mutation rewiring degron network	0.1667
p.E408K	DO219043	BLCA	ICGC	DSGYFS	DEG_SCF_TRCP1_1	397:402	Mutation rewiring degron network	0.1667
p.P2182L	TCGA-W3-AA1R	SKCM	TCGA	FSLYGD	LIG_APCC_ABBA_1	2184:2189	Mutation rewiring degron network	0.2778
p.P2182L	DO51275	SKCM	ICGC	FSLYGD	LIG_APCC_ABBA_1	2184:2189	Mutation rewiring degron network	0.2778
p.P1200S	TCGA-W3-AA1V	SKCM	TCGA	LFPHQE	LIG_APCC_ABBA_1	1189:1194	Mutation rewiring degron network	0.1667
p.P1200S	DO51276	SKCM	ICGC	LFPHQE	LIG_APCC_ABBA_1	1189:1194	Mutation rewiring degron network	0.1667
p.G2068E	DO48391	BLCA	ICGC	PRRDLSPMR	DEG_APCC_DBOX_1	2078:2086	Mutation rewiring degron network	0.0556
p.D2081N	DO227987	COCA	ICGC	PRRDLSPMR	DEG_APCC_DBOX_1	2078:2086	Mutation altering degron motif	0.5821
p.S1581N	DO222884	COCA	ICGC	PQSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.3056
p.A449T	DO234183	ESAD	ICGC	VTTTS	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.1944
p.A449T	DO233115	GACA	ICGC	VTTTS	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.1944
p.M470I	DO233847	GACA	ICGC	VKMFED	LIG_APCC_ABBA_1	468:473	Mutation altering degron motif	0.6507
p.E261D	DO233918	GACA	ICGC	LVPFTE	LIG_APCC_ABBA_1	247:252	Mutation rewiring degron network	0.0833
p.A437E	DO228976	LICA	ICGC	VTTTS	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.25
p.T1985K	DO228971	LICA	ICGC	LMTPSDS	DEG_SCF_FBW7_1	1983:1989	Mutation altering degron motif	0.8417
p.T1985K	DO229037	LICA	ICGC	LMTPSDS	DEG_SCF_FBW7_1	1983:1989	Mutation altering degron motif	0.8417
p.Q2190K	DO229026	LICA	ICGC	FSLYGD	LIG_APCC_ABBA_1	2184:2189	Mutation rewiring degron network	0.3056
p.A240D	DO229045	LICA	ICGC	LVPFTE	LIG_APCC_ABBA_1	247:252	Mutation rewiring degron network	0.1389
p.H391Q	DO229006	LICA	ICGC	DSGYFS	DEG_SCF_TRCP1_1	397:402	Mutation rewiring degron network	0.1667
p.R403H	DO231165	LUSC	ICGC	DSGYFS	DEG_SCF_TRCP1_1	397:402	Mutation rewiring degron network	0.3056
p.P474S	DO220895	MELA	ICGC	VKMFED	LIG_APCC_ABBA_1	468:473	Mutation rewiring degron network	0.3056
p.P2072L	DO222494	MELA	ICGC	PRRDLSPMR	DEG_APCC_DBOX_1	2078:2086	Mutation rewiring degron network	0.1667
p.C430W	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.0556
p.C430W	ACH-000924	Lung Cancer	CCLE	VTTTS	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.0556
p.C430W	NCI-H2172	lung	COSMIC	VTTTS	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.0556
p.P2197Q	SIDM00845	Burkitt's Lymphoma	GDSC	FSLYGD	LIG_APCC_ABBA_1	2184:2189	Mutation rewiring degron network	0.1111
p.P2197Q	SIDM00946	T-Lymphoblastic Leukemia	GDSC	FSLYGD	LIG_APCC_ABBA_1	2184:2189	Mutation rewiring degron network	0.1111
p.P2197Q	ACH-000786	Lymphoma	CCLE	FSLYGD	LIG_APCC_ABBA_1	2184:2189	Mutation rewiring degron network	0.1111
p.P2197Q	ACH-000992	Head and Neck Cancer	CCLE	FSLYGD	LIG_APCC_ABBA_1	2184:2189	Mutation rewiring degron network	0.1111
p.L2178I	SIDM00845	Burkitt's Lymphoma	GDSC	FSLYGD	LIG_APCC_ABBA_1	2184:2189	Mutation rewiring degron network	0.1667
p.L2178I	SIDM00461	Acute Myeloid Leukemia	GDSC	FSLYGD	LIG_APCC_ABBA_1	2184:2189	Mutation rewiring degron network	0.1667
p.L2178I	SIDM00946	T-Lymphoblastic Leukemia	GDSC	FSLYGD	LIG_APCC_ABBA_1	2184:2189	Mutation rewiring degron network	0.1667
p.L2178I	SIDM01519	Head and Neck Carcinoma	GDSC	FSLYGD	LIG_APCC_ABBA_1	2184:2189	Mutation rewiring degron network	0.1667
p.S549Y	SIDM00193	Colorectal Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.712
p.S549Y	ACH-000991	Colon/Colorectal Cancer	CCLE	VPTSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.712
p.S549Y	SNU-81	large intestine	COSMIC	VPTSS	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.712
p.D259G	SIDM00223	Small Cell Lung Carcinoma	GDSC	LVPFTE	LIG_APCC_ABBA_1	247:252	Mutation rewiring degron network	0.1389
p.D1591H	SIDM00767	Small Cell Lung Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.1944
p.D1591H	ACH-001136	Lung Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.1944
p.D1591H	NCI-H187	lung	COSMIC	PQSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.1944
p.R447H	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.25
p.R447H	NCI-H1155	lung	COSMIC	VTTTS	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.25
p.R452M	SIDM00537	Colorectal Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.1111
p.R452M	ACH-000982	Colon/Colorectal Cancer	CCLE	VTTTS	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.1111
p.R452M	ACH-001345	Colon/Colorectal Cancer	CCLE	VTTTS	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.1111
p.R452M	GP5d	large intestine	COSMIC	VTTTS	DEG_SPOP_SBC_1	440:444	Mutation rewiring degron network	0.1111
p.C1990R	SIDM00217	Colorectal Carcinoma	GDSC	LMTPSDS	DEG_SCF_FBW7_1	1983:1989	Mutation rewiring degron network	0.3056
p.C1990R	SIDM00634	Ewing's Sarcoma	GDSC	LMTPSDS	DEG_SCF_FBW7_1	1983:1989	Mutation rewiring degron network	0.3056
p.A1589V	SIDM01608	Endometrial Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.25
p.A1589V	ACH-000990	Endometrial/Uterine Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.25
p.A2094T	ACH-001610	Brain Cancer	CCLE	PRRDLSPMR	DEG_APCC_DBOX_1	2078:2086	Mutation rewiring degron network	0.1111
p.L2096F	ACH-001864	Bile Duct Cancer	CCLE	PRRDLSPMR	DEG_APCC_DBOX_1	2078:2086	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HIVEP2

UniProt ID: P31629

Entrez ID: 3097

Protein name: Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HIVEP2 in