DegronMD

Uniprot ID: P31629

Source protein: Transcription factor HIVEP2

Source gene: HIVEP2

Class: DEG_SPOP_SBC_1

Location: 440:444

E3 ligase: SPOP

DEGRON score: 0.9813

ASA_SCORE: 87.34

COIL: 0.7846

CONS_SCORE: 0.24

DSS_SCORE: 0.5202

HELIX: 0.0438

FCONS_SCORE: 1.0033

RIG_SCORE: 0.7677

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R431W	TCGA-66-2744	LUSC	TCGA	VTTTS	DEG_SPOP_SBC_1	0.0833
p.R431W	TCGA-XK-AAIW	PRAD	TCGA	VTTTS	DEG_SPOP_SBC_1	0.0833
p.R431W	DO27025	LUSC	ICGC	VTTTS	DEG_SPOP_SBC_1	0.0833
p.R431W	DO51407	PRAD	ICGC	VTTTS	DEG_SPOP_SBC_1	0.0833
p.R431W	SIDM00217	Colorectal Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	0.0833
p.R431W	ACH-000999	Colon/Colorectal Cancer	CCLE	VTTTS	DEG_SPOP_SBC_1	0.0833
p.R431W	SNU-1040	large_intestine	COSMIC	VTTTS	DEG_SPOP_SBC_1	0.0833
p.R447C	TCGA-AX-A1CE	UCEC	TCGA	VTTTS	DEG_SPOP_SBC_1	0.25
p.R447C	DO42280	UCEC	ICGC	VTTTS	DEG_SPOP_SBC_1	0.25
p.R447C	ACH-001147	Lymphoma	CCLE	VTTTS	DEG_SPOP_SBC_1	0.25
p.A449T	DO234183	ESAD	ICGC	VTTTS	DEG_SPOP_SBC_1	0.1944
p.A449T	DO233115	GACA	ICGC	VTTTS	DEG_SPOP_SBC_1	0.1944
p.A437E	DO228976	LICA	ICGC	VTTTS	DEG_SPOP_SBC_1	0.25
p.C430W	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	0.0556
p.C430W	ACH-000924	Lung Cancer	CCLE	VTTTS	DEG_SPOP_SBC_1	0.0556
p.C430W	NCI-H2172	lung	COSMIC	VTTTS	DEG_SPOP_SBC_1	0.0556
p.R447H	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	0.25
p.R447H	NCI-H1155	lung	COSMIC	VTTTS	DEG_SPOP_SBC_1	0.25
p.R452M	SIDM00537	Colorectal Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	0.1111
p.R452M	ACH-000982	Colon/Colorectal Cancer	CCLE	VTTTS	DEG_SPOP_SBC_1	0.1111
p.R452M	ACH-001345	Colon/Colorectal Cancer	CCLE	VTTTS	DEG_SPOP_SBC_1	0.1111
p.R452M	GP5d	large_intestine	COSMIC	VTTTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13646	Keratin, type I cytoskeletal 13	DEG_SPOP_SBC_1	433:437	VTTTS	SPOP	0.9542	More...
P13646	Keratin, type I cytoskeletal 13	DEG_SPOP_SBC_1	441:445	VTTTS	SPOP	0.8837	More...
P31629	Transcription factor HIVEP2	DEG_SPOP_SBC_1	440:444	VTTTS	SPOP	0.9813	More...
Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	DEG_SPOP_SBC_1	484:488	VTTTS	SPOP	0.5226	More...
Q96FS4	Signal-induced proliferation-associated protein 1	DEG_SPOP_SBC_1	544:548	VTTTS	SPOP	0.9169	More...
Q9NYZ4	Sialic acid-binding Ig-like lectin 8	DEG_SPOP_SBC_1	233:237	VTTTS	SPOP	0.8068	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	1283:1287	VTTTS	SPOP	0.5985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons