DegronMD - Q13469(NFATC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q123H	TCGA-49-AAR9	LUAD	TCGA	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.25
p.Q123H	DO218921	LUAD	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.25
p.Q123L	TCGA-49-AAR9	LUAD	TCGA	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.25
p.Q123L	DO218921	LUAD	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.25
p.K497E	TCGA-67-3770	LUAD	TCGA	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation blocking ubiquitination signal	0.5278
p.I122M	TCGA-69-7978	LUAD	TCGA	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.2778
p.I122M	DO24920	LUAD	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.2778
p.P117L	TCGA-90-A4ED	LUSC	TCGA	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation altering degron motif	0.7582
p.P117L	DO45482	LUSC	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation altering degron motif	0.7582
p.R478Q	TCGA-A8-A08G	BRCA	TCGA	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.1667
p.R478Q	TCGA-AZ-4315	COAD	TCGA	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.1667
p.R478Q	TCGA-ND-A4WC	UCS	TCGA	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.1667
p.T487S	TCGA-B5-A1MX	UCEC	TCGA	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation altering degron motif	0.6005
p.T487S	TCGA-G4-6317	COAD	TCGA	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation altering degron motif	0.6005
p.I492L	TCGA-BC-4073	LIHC	TCGA	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.2222
p.P117A	TCGA-BH-A0B6	BRCA	TCGA	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation altering degron motif	0.7503
p.P117A	DO2641	BRCA	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation altering degron motif	0.7503
p.R112Q	TCGA-EO-A22R	UCEC	TCGA	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.3056
p.R112Q	DO233898	GACA	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.3056
p.R112Q	DO42713	UCEC	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.3056
p.D109N	DO49943	CESC	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.2222
p.E497K	DO222765	COCA	ICGC	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation blocking ubiquitination signal	0.5278
p.E497K	DO26830	LUSC	ICGC	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation blocking ubiquitination signal	0.5278
p.R124H	DO16101	HNSC	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.2222
p.R124H	DO47849	STAD	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.2222
p.R124H	DO42713	UCEC	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.2222
p.R124H	DO43971	UCEC	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.2222
p.L483P	DO52115	HNSC	ICGC	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation blocking phosphorylation signal	0.75
p.T106N	DO229018	LICA	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.1389
p.A124E	DO229019	LICA	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.2222
p.H125Q	DO229024	LICA	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.1944
p.H125Q	DO229034	LICA	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.1944
p.P127T	DO229008	LICA	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.1389
p.S107I	DO24349	LUAD	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation blocking phosphorylation signal	0.6111
p.R124C	DO25262	LUAD	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.2222
p.R124C	23132-87	stomach	COSMIC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.2222
p.S107L	DO46597	OV	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation blocking phosphorylation signal	0.6111
p.D109A	DO229459	SKCA	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.2222
p.P110L	DO37515	SKCM	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation blocking phosphorylation signal	0.6944
p.P110L	DO221004	WT	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation blocking phosphorylation signal	0.6944
p.G484W	DO47491	SKCM	ICGC	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation altering degron motif	0.7825
p.A115T	DO38404	STAD	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation altering degron motif	0.7139
p.P490L	DO51740	STAD	ICGC	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.2778
p.P487L	DO229259	THCA	ICGC	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation altering degron motif	0.7582
p.A496V	DO229275	THCA	ICGC	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.1111
p.I475V	DO41536	UCEC	ICGC	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.0833
p.P128L	DO41235	UCEC	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.1111
p.P111S	SIDM00270	Head and Neck Carcinoma	GDSC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.2778
p.P111S	ACH-002294	Head and Neck Cancer	CCLE	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.2778
p.P111S	PCI-15A	upper aerodigestive tract	COSMIC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.2778
p.G494D	SIDM00364	B-Lymphoblastic Leukemia	GDSC	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.1667
p.G494D	ACH-002059	Leukemia	CCLE	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.1667
p.G494D	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.1667
p.T480R	SIDM00619	Thyroid Gland Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.2222
p.T480R	KMH-2	thyroid	COSMIC	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.2222
p.R129C	SIDM00256	Neuroblastoma	GDSC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.0833
p.R129C	ACH-002281	Neuroblastoma	CCLE	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.0833
p.R129C	NB14	autonomic ganglia	COSMIC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.0833
p.V493A	SIDM00721	Small Cell Lung Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.1944
p.V493A	ACH-002171	Lung Cancer	CCLE	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.1944
p.V493A	NCI-H250	lung	COSMIC	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.1944
p.G124R	MCC13	skin	COSMIC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.2222
p.P482R	MKN1	stomach	COSMIC	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation blocking ubiquitination signal	0.7222
p.G474D	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.0556
p.P112S	HT-3	cervix	COSMIC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.3056
p.R109C	NB14	autonomic ganglia	COSMIC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.2222

Kaplan plot for NFATC2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NFATC2

UniProt ID: Q13469

Entrez ID: 4773

Protein name: Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NFATC2 in