DegronMD - Q13469(NFATC2)

FUNCTION: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway. {ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017}.

GO - Biological processes (BP): B cell receptor signaling pathway [GO:0050853]; calcineurin-NFAT signaling cascade [GO:0033173]; cell migration [GO:0016477]; cellular response to DNA damage stimulus [GO:0006974]; myotube cell development [GO:0014904]; negative regulation of vascular associated smooth muscle cell differentiation [G... View more >>

GO - Molecular function (MF): chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding tra... View more >>

GO - Cellular component (CC): chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; transcription factor AP-1 complex [GO:0035976]; transcription regulator complex [GO:0005667]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G484W	DO47491	SKCM	ICGC	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation altering degron motif	0.7825
p.P117L	TCGA-90-A4ED	LUSC	TCGA	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation altering degron motif	0.7582
p.P117L	DO45482	LUSC	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation altering degron motif	0.7582
p.P487L	DO229259	THCA	ICGC	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation altering degron motif	0.7582
p.P117A	TCGA-BH-A0B6	BRCA	TCGA	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation altering degron motif	0.7503
p.P117A	DO2641	BRCA	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation altering degron motif	0.7503
p.L483P	DO52115	HNSC	ICGC	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation blocking phosphorylation signal	0.75
p.P482R	MKN1	stomach	COSMIC	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation blocking ubiquitination signal	0.7222
p.A115T	DO38404	STAD	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation altering degron motif	0.7139
p.P110L	DO37515	SKCM	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation blocking phosphorylation signal	0.6944
p.P110L	DO221004	WT	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation blocking phosphorylation signal	0.6944
p.S107I	DO24349	LUAD	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation blocking phosphorylation signal	0.6111
p.S107L	DO46597	OV	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation blocking phosphorylation signal	0.6111
p.T487S	TCGA-B5-A1MX	UCEC	TCGA	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation altering degron motif	0.6005
p.T487S	TCGA-G4-6317	COAD	TCGA	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation altering degron motif	0.6005
p.K497E	TCGA-67-3770	LUAD	TCGA	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation blocking ubiquitination signal	0.5278
p.E497K	DO222765	COCA	ICGC	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation blocking ubiquitination signal	0.5278
p.E497K	DO26830	LUSC	ICGC	VTTTS	DEG_SPOP_SBC_1	484:488	Mutation blocking ubiquitination signal	0.5278
p.R112Q	TCGA-EO-A22R	UCEC	TCGA	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.3056
p.R112Q	DO233898	GACA	ICGC	IEITPSHE	DEG_SCF_FBW7_2	113:120	Mutation rewiring degron network	0.3056

Showing 1 to 20 of 66 entries

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No resistance data available for this Degron.

Kaplan plot for NFATC2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NFATC2

UniProt ID: Q13469

Entrez ID: 4773

Protein name: Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for NFATC2 in