DegronMD

Uniprot ID: Q13469

Source protein: Nuclear factor of activated T-cells, cytoplasmic 2

Source gene: NFATC2

Class: DEG_SPOP_SBC_1

Location: 484:488

E3 ligase: SPOP

DEGRON score: 0.5226

ASA_SCORE: 64.16

COIL: 0.648

CONS_SCORE: 0.5979

DSS_SCORE: 0.2759

HELIX: 0.0122

FCONS_SCORE: 0.945

RIG_SCORE: 0.812

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K497E	TCGA-67-3770	LUAD	TCGA	VTTTS	DEG_SPOP_SBC_1	0.5278
p.R478Q	TCGA-A8-A08G	BRCA	TCGA	VTTTS	DEG_SPOP_SBC_1	0.1667
p.R478Q	TCGA-AZ-4315	COAD	TCGA	VTTTS	DEG_SPOP_SBC_1	0.1667
p.R478Q	TCGA-ND-A4WC	UCS	TCGA	VTTTS	DEG_SPOP_SBC_1	0.1667
p.T487S	TCGA-B5-A1MX	UCEC	TCGA	VTTTS	DEG_SPOP_SBC_1	0.6005
p.T487S	TCGA-G4-6317	COAD	TCGA	VTTTS	DEG_SPOP_SBC_1	0.6005
p.I492L	TCGA-BC-4073	LIHC	TCGA	VTTTS	DEG_SPOP_SBC_1	0.2222
p.E497K	DO222765	COCA	ICGC	VTTTS	DEG_SPOP_SBC_1	0.5278
p.E497K	DO26830	LUSC	ICGC	VTTTS	DEG_SPOP_SBC_1	0.5278
p.L483P	DO52115	HNSC	ICGC	VTTTS	DEG_SPOP_SBC_1	0.75
p.G484W	DO47491	SKCM	ICGC	VTTTS	DEG_SPOP_SBC_1	0.7825
p.P490L	DO51740	STAD	ICGC	VTTTS	DEG_SPOP_SBC_1	0.2778
p.P487L	DO229259	THCA	ICGC	VTTTS	DEG_SPOP_SBC_1	0.7582
p.A496V	DO229275	THCA	ICGC	VTTTS	DEG_SPOP_SBC_1	0.1111
p.I475V	DO41536	UCEC	ICGC	VTTTS	DEG_SPOP_SBC_1	0.0833
p.G494D	SIDM00364	B-Lymphoblastic Leukemia	GDSC	VTTTS	DEG_SPOP_SBC_1	0.1667
p.G494D	ACH-002059	Leukemia	CCLE	VTTTS	DEG_SPOP_SBC_1	0.1667
p.G494D	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	VTTTS	DEG_SPOP_SBC_1	0.1667
p.T480R	SIDM00619	Thyroid Gland Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	0.2222
p.T480R	KMH-2	thyroid	COSMIC	VTTTS	DEG_SPOP_SBC_1	0.2222
p.V493A	SIDM00721	Small Cell Lung Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	0.1944
p.V493A	ACH-002171	Lung Cancer	CCLE	VTTTS	DEG_SPOP_SBC_1	0.1944
p.V493A	NCI-H250	lung	COSMIC	VTTTS	DEG_SPOP_SBC_1	0.1944
p.P482R	MKN1	stomach	COSMIC	VTTTS	DEG_SPOP_SBC_1	0.7222
p.G474D	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	VTTTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13646	Keratin, type I cytoskeletal 13	DEG_SPOP_SBC_1	433:437	VTTTS	SPOP	0.9542	More...
P13646	Keratin, type I cytoskeletal 13	DEG_SPOP_SBC_1	441:445	VTTTS	SPOP	0.8837	More...
P31629	Transcription factor HIVEP2	DEG_SPOP_SBC_1	440:444	VTTTS	SPOP	0.9813	More...
Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	DEG_SPOP_SBC_1	484:488	VTTTS	SPOP	0.5226	More...
Q96FS4	Signal-induced proliferation-associated protein 1	DEG_SPOP_SBC_1	544:548	VTTTS	SPOP	0.9169	More...
Q9NYZ4	Sialic acid-binding Ig-like lectin 8	DEG_SPOP_SBC_1	233:237	VTTTS	SPOP	0.8068	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	1283:1287	VTTTS	SPOP	0.5985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons