DegronMD - Q6ZU65(UBN2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1290I	TCGA-06-5408	GBM	TCGA	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation rewiring degron network	0.25
p.T1290I	DO12862	GBM	ICGC	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation rewiring degron network	0.25
p.H161Y	TCGA-14-1794	GBM	TCGA	KKLIHTE	LIG_APCC_ABBAyCdc20_2	157:163	Mutation altering degron motif	0.6118
p.H161Y	DO13024	GBM	ICGC	KKLIHTE	LIG_APCC_ABBAyCdc20_2	157:163	Mutation altering degron motif	0.6118
p.K1016N	TCGA-37-4130	LUSC	TCGA	VPSTT	DEG_SPOP_SBC_1	1004:1008	Mutation substituting flanking lysine	0.2222
p.K1016N	DO26490	LUSC	ICGC	VPSTT	DEG_SPOP_SBC_1	1004:1008	Mutation substituting flanking lysine	0.2222
p.K1016M	TCGA-56-8082	LUSC	TCGA	VPSTT	DEG_SPOP_SBC_1	1004:1008	Mutation substituting flanking lysine	0.2222
p.K1016M	DO223722	LUSC	ICGC	VPSTT	DEG_SPOP_SBC_1	1004:1008	Mutation substituting flanking lysine	0.2222
p.T1285I	TCGA-66-2791	LUSC	TCGA	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation altering degron motif	0.7078
p.T1285I	DO26435	LUSC	ICGC	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation altering degron motif	0.7078
p.S909C	TCGA-91-6830	LUAD	TCGA	VSSSS	DEG_SPOP_SBC_1	897:901	Mutation rewiring degron network	0.1111
p.S909C	DO25867	LUAD	ICGC	VSSSS	DEG_SPOP_SBC_1	897:901	Mutation rewiring degron network	0.1111
p.A906D	TCGA-A5-A0G2	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	897:901	Mutation rewiring degron network	0.1944
p.A906D	DO41235	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	897:901	Mutation rewiring degron network	0.1944
p.H896Y	TCGA-AP-A051	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	897:901	Mutation rewiring degron network	0.3056
p.H896Y	DO42673	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	897:901	Mutation rewiring degron network	0.3056
p.S909Y	TCGA-AP-A056	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	897:901	Mutation rewiring degron network	0.1111
p.S909Y	DO43971	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	897:901	Mutation rewiring degron network	0.1111
p.S899P	TCGA-AP-A1DK	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	897:901	Mutation altering degron motif	0.6752
p.S899P	DO42033	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	897:901	Mutation altering degron motif	0.6752
p.N167S	TCGA-B5-A0JR	UCEC	TCGA	KKLIHTE	LIG_APCC_ABBAyCdc20_2	157:163	Mutation rewiring degron network	0.2222
p.N167S	DO41791	UCEC	ICGC	KKLIHTE	LIG_APCC_ABBAyCdc20_2	157:163	Mutation rewiring degron network	0.2222
p.Q994E	TCGA-BK-A0C9	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	1004:1008	Mutation rewiring degron network	0.0556
p.Q994E	TCGA-K4-A6MB	BLCA	TCGA	VPSTT	DEG_SPOP_SBC_1	1004:1008	Mutation rewiring degron network	0.0556
p.Q994E	DO44077	BLCA	ICGC	VPSTT	DEG_SPOP_SBC_1	1004:1008	Mutation rewiring degron network	0.0556
p.Q994E	DO41253	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	1004:1008	Mutation rewiring degron network	0.0556
p.S1102T	TCGA-CV-6948	HNSC	TCGA	PSSSS	DEG_SPOP_SBC_1	1089:1093	Mutation blocking phosphorylation signal	0.5278
p.S1102T	DO14188	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	1089:1093	Mutation blocking phosphorylation signal	0.5278
p.L752I	TCGA-D8-A1XQ	BRCA	TCGA	AASSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.0556
p.L752I	DO3095	BRCA	ICGC	AASSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.0556
p.S1079F	TCGA-DX-A8BP	SARC	TCGA	PTPKPT	DEG_SCF_FBW7_1	1081:1086	Mutation rewiring degron network	0.2778
p.S1079F	TCGA-DX-A8BP	SARC	TCGA	PSSSS	DEG_SPOP_SBC_1	1089:1093	Mutation rewiring degron network	0.0556
p.S1079F	DO220056	SARC	ICGC	PTPKPT	DEG_SCF_FBW7_1	1081:1086	Mutation rewiring degron network	0.2778
p.S1079F	DO220056	SARC	ICGC	PSSSS	DEG_SPOP_SBC_1	1089:1093	Mutation rewiring degron network	0.0556
p.S1001T	TCGA-EB-A4IS	SKCM	TCGA	VPSTT	DEG_SPOP_SBC_1	1004:1008	Mutation rewiring degron network	0.25
p.S1001T	DO47281	SKCM	ICGC	VPSTT	DEG_SPOP_SBC_1	1004:1008	Mutation rewiring degron network	0.25
p.D168N	TCGA-EB-A553	SKCM	TCGA	KKLIHTE	LIG_APCC_ABBAyCdc20_2	157:163	Mutation rewiring degron network	0.1944
p.D168N	DO47329	SKCM	ICGC	KKLIHTE	LIG_APCC_ABBAyCdc20_2	157:163	Mutation rewiring degron network	0.1944
p.P745Q	TCGA-EE-A2GK	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.25
p.P745Q	DO37738	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.25
p.G995V	TCGA-EE-A3AD	SKCM	TCGA	VPSTT	DEG_SPOP_SBC_1	1004:1008	Mutation rewiring degron network	0.0833
p.G995V	DO37707	SKCM	ICGC	VPSTT	DEG_SPOP_SBC_1	1004:1008	Mutation rewiring degron network	0.0833
p.D164E	TCGA-MM-A84U	KIRC	TCGA	KKLIHTE	LIG_APCC_ABBAyCdc20_2	157:163	Mutation rewiring degron network	0.3056
p.D164E	DO50653	KIRC	ICGC	KKLIHTE	LIG_APCC_ABBAyCdc20_2	157:163	Mutation rewiring degron network	0.3056
p.S1287L	TCGA-UY-A9PB	BLCA	TCGA	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation altering degron motif	0.7667
p.S1287L	DO219041	BLCA	ICGC	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation altering degron motif	0.7667
p.S1287L	ACH-001513	Cervical Cancer	CCLE	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation altering degron motif	0.7667
p.Q902E	TCGA-XF-A8HE	BLCA	TCGA	VSSSS	DEG_SPOP_SBC_1	897:901	Mutation rewiring degron network	0.3056
p.Q902E	DO49797	BLCA	ICGC	VSSSS	DEG_SPOP_SBC_1	897:901	Mutation rewiring degron network	0.3056
p.E154K	DO7801	COAD	ICGC	KKLIHTE	LIG_APCC_ABBAyCdc20_2	157:163	Mutation rewiring degron network	0.25
p.P1081R	DO227999	COCA	ICGC	PTPKPT	DEG_SCF_FBW7_1	1081:1086	Mutation altering degron motif	0.7512
p.F1274C	DO222798	COCA	ICGC	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation rewiring degron network	0.0833
p.M1018T	DO222737	COCA	ICGC	VPSTT	DEG_SPOP_SBC_1	1004:1008	Mutation rewiring degron network	0.0556
p.A1096E	DO27883	ORCA	ICGC	PTPKPT	DEG_SCF_FBW7_1	1081:1086	Mutation rewiring degron network	0.0556
p.A1096E	DO27883	ORCA	ICGC	PSSSS	DEG_SPOP_SBC_1	1089:1093	Mutation rewiring degron network	0.25
p.T1278M	DO229259	THCA	ICGC	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation rewiring degron network	0.1944
p.I1273L	SIDM00845	Burkitt's Lymphoma	GDSC	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation rewiring degron network	0.0556
p.I1273L	SIDM00461	Acute Myeloid Leukemia	GDSC	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation rewiring degron network	0.0556
p.I1273L	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation rewiring degron network	0.0556
p.I1273L	SIDM01519	Head and Neck Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation rewiring degron network	0.0556
p.I1273L	ACH-000786	Lymphoma	CCLE	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation rewiring degron network	0.0556
p.I1273L	ACH-000992	Head and Neck Cancer	CCLE	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation rewiring degron network	0.0556
p.I1273L	ACH-001067	Brain Cancer	CCLE	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation rewiring degron network	0.0556
p.I1273L	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation rewiring degron network	0.0556
p.I1273L	Daudi	haematopoietic and lymphoid tissue	COSMIC	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation rewiring degron network	0.0556
p.F1274L	SIDM00845	Burkitt's Lymphoma	GDSC	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation rewiring degron network	0.0833
p.F1274L	SIDM00461	Acute Myeloid Leukemia	GDSC	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation rewiring degron network	0.0833
p.F1274L	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation rewiring degron network	0.0833
p.F1274L	SIDM01519	Head and Neck Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation rewiring degron network	0.0833
p.F1274L	Daudi	haematopoietic and lymphoid tissue	COSMIC	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation rewiring degron network	0.0833
p.F1274L	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation rewiring degron network	0.0833
p.T1285A	SIDM00845	Burkitt's Lymphoma	GDSC	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation altering degron motif	0.7139
p.T1285A	SIDM01519	Head and Neck Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation altering degron motif	0.7139
p.T1285A	ACH-000786	Lymphoma	CCLE	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation altering degron motif	0.7139
p.T1285A	ACH-000992	Head and Neck Cancer	CCLE	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation altering degron motif	0.7139
p.T1285A	Daudi	haematopoietic and lymphoid tissue	COSMIC	VTTTS	DEG_SPOP_SBC_1	1283:1287	Mutation altering degron motif	0.7139
p.I736V	SIDM01117	Small Cell Lung Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.1944
p.I736V	SIDM01117	Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.2778
p.S890Y	SIDM00193	Colorectal Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	897:901	Mutation rewiring degron network	0.1389
p.S890Y	ACH-000991	Colon/Colorectal Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	897:901	Mutation rewiring degron network	0.1389
p.S890Y	SNU-81	large intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	897:901	Mutation rewiring degron network	0.1389
p.V1071A	SIDM00683	Prostate Carcinoma	GDSC	PTPKPT	DEG_SCF_FBW7_1	1081:1086	Mutation rewiring degron network	0.0556
p.V1071A	ACH-000977	lymph node	CCLE	PTPKPT	DEG_SCF_FBW7_1	1081:1086	Mutation rewiring degron network	0.0556
p.V1071A	LNCaP-Clone-FGC	prostate	COSMIC	PTPKPT	DEG_SCF_FBW7_1	1081:1086	Mutation rewiring degron network	0.0556
p.I160F	SIDM00628	Breast Carcinoma	GDSC	KKLIHTE	LIG_APCC_ABBAyCdc20_2	157:163	Mutation altering degron motif	0.7415
p.G995W	ACH-001786	Colon/Colorectal Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	1004:1008	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UBN2

UniProt ID: Q6ZU65

Entrez ID: 254048

Protein name: Ubinuclein-2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UBN2 in