DegronMD

Uniprot ID: Q6ZU65

Source protein: Ubinuclein-2

Source gene: UBN2

Class: DEG_SPOP_SBC_1

Location: 1004:1008

E3 ligase: SPOP

DEGRON score: 0.8553

ASA_SCORE: 90.2

COIL: 0.9548

CONS_SCORE: 0.3099

DSS_SCORE: 0.4776

HELIX: 0.0162

FCONS_SCORE: 1.0179

RIG_SCORE: 0.6771

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1016N	TCGA-37-4130	LUSC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.2222
p.K1016N	DO26490	LUSC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.K1016M	TCGA-56-8082	LUSC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.2222
p.K1016M	DO223722	LUSC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.Q994E	TCGA-BK-A0C9	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.0556
p.Q994E	TCGA-K4-A6MB	BLCA	TCGA	VPSTT	DEG_SPOP_SBC_1	0.0556
p.Q994E	DO44077	BLCA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.0556
p.Q994E	DO41253	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.0556
p.S1001T	TCGA-EB-A4IS	SKCM	TCGA	VPSTT	DEG_SPOP_SBC_1	0.25
p.S1001T	DO47281	SKCM	ICGC	VPSTT	DEG_SPOP_SBC_1	0.25
p.G995V	TCGA-EE-A3AD	SKCM	TCGA	VPSTT	DEG_SPOP_SBC_1	0.0833
p.G995V	DO37707	SKCM	ICGC	VPSTT	DEG_SPOP_SBC_1	0.0833
p.M1018T	DO222737	COCA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.0556
p.G995W	ACH-001786	Colon/Colorectal Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	567:571	VPSTT	SPOP	0.9968	More...
O15020	Spectrin beta chain, non-erythrocytic 2	DEG_SPOP_SBC_1	2342:2346	VPSTT	SPOP	0.9599	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	566:570	VPSTT	SPOP	0.7372	More...
P18583	Protein SON	DEG_SPOP_SBC_1	675:679	VPSTT	SPOP	0.8249	More...
P56975	Pro-neuregulin-3, membrane-bound isoform	DEG_SPOP_SBC_1	193:197	VPSTT	SPOP	0.9767	More...
Q13123	Protein Red	DEG_SPOP_SBC_1	326:330	VPSTT	SPOP	0.9958	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	533:537	VPSTT	SPOP	0.9759	More...
Q1W6H9	Protein FAM110C	DEG_SPOP_SBC_1	280:284	VPSTT	SPOP	0.9945	More...
Q8NEV8	Exophilin-5	DEG_SPOP_SBC_1	900:904	VPSTT	SPOP	0.9989	More...
Q9UH73	Transcription factor COE1	DEG_SPOP_SBC_1	471:475	VPSTT	SPOP	0.9983	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	1004:1008	VPSTT	SPOP	0.8553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons