DegronMD - O15020(SPTBN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S2119T	TCGA-29-1698	OV	TCGA	EPTASVPPG	DEG_SIAH_1	2102:2110	Mutation rewiring degron network	0.0833
p.S2119T	DO28531	OV	ICGC	EPTASVPPG	DEG_SIAH_1	2102:2110	Mutation rewiring degron network	0.0833
p.R2095Q	TCGA-85-A511	LUSC	TCGA	EPTASVPPG	DEG_SIAH_1	2102:2110	Mutation rewiring degron network	0.1389
p.R2095Q	DO45509	LUSC	ICGC	EPTASVPPG	DEG_SIAH_1	2102:2110	Mutation rewiring degron network	0.1389
p.R2292H	TCGA-AJ-A3EL	UCEC	TCGA	DYR	CBL_MET	2288:2290	Mutation rewiring degron network	0.2778
p.R2292H	DO41542	UCEC	ICGC	DYR	CBL_MET	2288:2290	Mutation rewiring degron network	0.2778
p.R2292H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	2288:2290	Mutation rewiring degron network	0.2778
p.R2292H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	2288:2290	Mutation rewiring degron network	0.2778
p.R2292H	ACH-000995	Leukemia	CCLE	DYR	CBL_MET	2288:2290	Mutation rewiring degron network	0.2778
p.R2292H	Jurkat	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	2288:2290	Mutation rewiring degron network	0.2778
p.R2290Q	TCGA-CK-4951	COAD	TCGA	DYR	CBL_MET	2288:2290	Mutation altering degron motif	0.7329
p.R2290Q	DO10582	COAD	ICGC	DYR	CBL_MET	2288:2290	Mutation altering degron motif	0.7329
p.A2279T	TCGA-DF-A2KU	UCEC	TCGA	DYR	CBL_MET	2288:2290	Mutation rewiring degron network	0.0833
p.A2279T	DO223286	UCEC	ICGC	DYR	CBL_MET	2288:2290	Mutation rewiring degron network	0.0833
p.G2283D	TCGA-EE-A3JD	SKCM	TCGA	DYR	CBL_MET	2288:2290	Mutation rewiring degron network	0.1944
p.G2283D	DO50299	SKCM	ICGC	DYR	CBL_MET	2288:2290	Mutation rewiring degron network	0.1944
p.G2283S	TCGA-EE-A3JD	SKCM	TCGA	DYR	CBL_MET	2288:2290	Mutation rewiring degron network	0.1944
p.G2283S	DO50299	SKCM	ICGC	DYR	CBL_MET	2288:2290	Mutation rewiring degron network	0.1944
p.A2286T	TCGA-EO-A22R	UCEC	TCGA	DYR	CBL_MET	2288:2290	Mutation rewiring degron network	0.2778
p.A2286T	DO42713	UCEC	ICGC	DYR	CBL_MET	2288:2290	Mutation rewiring degron network	0.2778
p.A2286T	SIDM02041	Colorectal Carcinoma	GDSC	DYR	CBL_MET	2288:2290	Mutation rewiring degron network	0.2778
p.A2286T	SIDM00680	Colorectal Carcinoma	GDSC	DYR	CBL_MET	2288:2290	Mutation rewiring degron network	0.2778
p.A2286T	ACH-000957	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	2288:2290	Mutation rewiring degron network	0.2778
p.A2286T	LS-180	large intestine	COSMIC	DYR	CBL_MET	2288:2290	Mutation rewiring degron network	0.2778
p.E2336K	TCGA-FI-A2F8	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	2342:2346	Mutation rewiring degron network	0.1667
p.E2336K	DO42448	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	2342:2346	Mutation rewiring degron network	0.1667
p.A2100V	DO224700	BRCA	ICGC	EPTASVPPG	DEG_SIAH_1	2102:2110	Mutation rewiring degron network	0.2778
p.E2102K	DO222736	BTCA	ICGC	EPTASVPPG	DEG_SIAH_1	2102:2110	Mutation altering degron motif	0.591
p.E2093K	DO223394	CLLE	ICGC	EPTASVPPG	DEG_SIAH_1	2102:2110	Mutation rewiring degron network	0.0833
p.R2347W	DO222840	COCA	ICGC	VPSTT	DEG_SPOP_SBC_1	2342:2346	Mutation rewiring degron network	0.3056
p.S2119C	DO223032	ESCA	ICGC	EPTASVPPG	DEG_SIAH_1	2102:2110	Mutation rewiring degron network	0.0833
p.R2290G	DO228008	LAML	ICGC	DYR	CBL_MET	2288:2290	Mutation altering degron motif	0.7568
p.P2337T	DO229022	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	2342:2346	Mutation rewiring degron network	0.1944
p.L2342F	DO229459	SKCA	ICGC	VPSTT	DEG_SPOP_SBC_1	2342:2346	Mutation altering degron motif	0.6981
p.S2334P	DO223908	SKCM	ICGC	VPSTT	DEG_SPOP_SBC_1	2342:2346	Mutation rewiring degron network	0.1111
p.P2338T	DO43626	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	2342:2346	Mutation rewiring degron network	0.2222
p.R2356Q	DO52412	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	2342:2346	Mutation rewiring degron network	0.0556
p.R2280K	SIDM00373	Endometrial Carcinoma	GDSC	DYR	CBL_MET	2288:2290	Mutation rewiring degron network	0.1111
p.R2280K	ACH-000974	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	2288:2290	Mutation rewiring degron network	0.1111
p.E2093Q	SIDM00447	B-Lymphoblastic Leukemia	GDSC	EPTASVPPG	DEG_SIAH_1	2102:2110	Mutation rewiring degron network	0.0833
p.E2093Q	ACH-000960	Leukemia	CCLE	EPTASVPPG	DEG_SIAH_1	2102:2110	Mutation rewiring degron network	0.0833
p.E2093Q	REH	haematopoietic and lymphoid tissue	COSMIC	EPTASVPPG	DEG_SIAH_1	2102:2110	Mutation rewiring degron network	0.0833
p.R2095W	SIDM00528	Breast Carcinoma	GDSC	EPTASVPPG	DEG_SIAH_1	2102:2110	Mutation rewiring degron network	0.1389
p.R2095W	ACH-000934	Breast Cancer	CCLE	EPTASVPPG	DEG_SIAH_1	2102:2110	Mutation rewiring degron network	0.1389
p.R2095W	MDA-MB-361	breast	COSMIC	EPTASVPPG	DEG_SIAH_1	2102:2110	Mutation rewiring degron network	0.1389
p.E2093G	ACH-000960	Leukemia	CCLE	EPTASVPPG	DEG_SIAH_1	2102:2110	Mutation rewiring degron network	0.0833
p.E2093G	REH	haematopoietic and lymphoid tissue	COSMIC	EPTASVPPG	DEG_SIAH_1	2102:2110	Mutation rewiring degron network	0.0833
p.L2346I	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VPSTT	DEG_SPOP_SBC_1	2342:2346	Mutation altering degron motif	0.7174
p.P2341L	NB12	autonomic ganglia	COSMIC	VPSTT	DEG_SPOP_SBC_1	2342:2346	Mutation rewiring degron network	0.3056
p.P2341S	NCI-H2066	lung	COSMIC	VPSTT	DEG_SPOP_SBC_1	2342:2346	Mutation rewiring degron network	0.3056

Kaplan plot for SPTBN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPTBN2

UniProt ID: O15020

Entrez ID: 6712

Protein name: Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPTBN2 in