DegronMD

Uniprot ID: O15020

Source protein: Spectrin beta chain, non-erythrocytic 2

Source gene: SPTBN2

Class: DEG_SIAH_1

Location: 2102:2110

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.797

ASA_SCORE: 82.8556

COIL: 0.9123

CONS_SCORE: 0.2292

DSS_SCORE: 0.875

HELIX: 0.0421

FCONS_SCORE: 0.7964

RIG_SCORE: 0.5599

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2119T	TCGA-29-1698	OV	TCGA	EPTASVPPG	DEG_SIAH_1	0.0833
p.S2119T	DO28531	OV	ICGC	EPTASVPPG	DEG_SIAH_1	0.0833
p.R2095Q	TCGA-85-A511	LUSC	TCGA	EPTASVPPG	DEG_SIAH_1	0.1389
p.R2095Q	DO45509	LUSC	ICGC	EPTASVPPG	DEG_SIAH_1	0.1389
p.A2100V	DO224700	BRCA	ICGC	EPTASVPPG	DEG_SIAH_1	0.2778
p.E2102K	DO222736	BTCA	ICGC	EPTASVPPG	DEG_SIAH_1	0.591
p.E2093K	DO223394	CLLE	ICGC	EPTASVPPG	DEG_SIAH_1	0.0833
p.S2119C	DO223032	ESCA	ICGC	EPTASVPPG	DEG_SIAH_1	0.0833
p.E2093Q	SIDM00447	B-Lymphoblastic Leukemia	GDSC	EPTASVPPG	DEG_SIAH_1	0.0833
p.E2093Q	ACH-000960	Leukemia	CCLE	EPTASVPPG	DEG_SIAH_1	0.0833
p.E2093Q	REH	haematopoietic_and_lymphoid_tissue	COSMIC	EPTASVPPG	DEG_SIAH_1	0.0833
p.R2095W	SIDM00528	Breast Carcinoma	GDSC	EPTASVPPG	DEG_SIAH_1	0.1389
p.R2095W	ACH-000934	Breast Cancer	CCLE	EPTASVPPG	DEG_SIAH_1	0.1389
p.R2095W	MDA-MB-361	breast	COSMIC	EPTASVPPG	DEG_SIAH_1	0.1389
p.E2093G	ACH-000960	Leukemia	CCLE	EPTASVPPG	DEG_SIAH_1	0.0833
p.E2093G	REH	haematopoietic_and_lymphoid_tissue	COSMIC	EPTASVPPG	DEG_SIAH_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15020	Spectrin beta chain, non-erythrocytic 2	DEG_SIAH_1	2102:2110	EPTASVPPG	SIAH1,SIAH2,SIAH3	0.797	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons