DegronMD

Uniprot ID: O15020

Source protein: Spectrin beta chain, non-erythrocytic 2

Source gene: SPTBN2

Class: DEG_SPOP_SBC_1

Location: 2342:2346

E3 ligase: SPOP

DEGRON score: 0.9599

ASA_SCORE: 84.66

COIL: 0.941

CONS_SCORE: 0.2791

DSS_SCORE: 0.6784

HELIX: 0.0182

FCONS_SCORE: 0.965

RIG_SCORE: 0.6898

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2336K	TCGA-FI-A2F8	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.1667
p.E2336K	DO42448	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1667
p.R2347W	DO222840	COCA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.3056
p.P2337T	DO229022	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1944
p.L2342F	DO229459	SKCA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.6981
p.S2334P	DO223908	SKCM	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1111
p.P2338T	DO43626	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.R2356Q	DO52412	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.0556
p.L2346I	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.7174
p.P2341L	NB12	autonomic_ganglia	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.3056
p.P2341S	NCI-H2066	lung	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	567:571	VPSTT	SPOP	0.9968	More...
O15020	Spectrin beta chain, non-erythrocytic 2	DEG_SPOP_SBC_1	2342:2346	VPSTT	SPOP	0.9599	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	566:570	VPSTT	SPOP	0.7372	More...
P18583	Protein SON	DEG_SPOP_SBC_1	675:679	VPSTT	SPOP	0.8249	More...
P56975	Pro-neuregulin-3, membrane-bound isoform	DEG_SPOP_SBC_1	193:197	VPSTT	SPOP	0.9767	More...
Q13123	Protein Red	DEG_SPOP_SBC_1	326:330	VPSTT	SPOP	0.9958	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	533:537	VPSTT	SPOP	0.9759	More...
Q1W6H9	Protein FAM110C	DEG_SPOP_SBC_1	280:284	VPSTT	SPOP	0.9945	More...
Q8NEV8	Exophilin-5	DEG_SPOP_SBC_1	900:904	VPSTT	SPOP	0.9989	More...
Q9UH73	Transcription factor COE1	DEG_SPOP_SBC_1	471:475	VPSTT	SPOP	0.9983	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	1004:1008	VPSTT	SPOP	0.8553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons