DegronMD - Q13123(IK)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P312T	TCGA-A5-A0G2	UCEC	TCGA	MNIFED	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.2222
p.P312T	DO41235	UCEC	ICGC	MNIFED	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.2222
p.K309N	TCGA-AX-A05Z	UCEC	TCGA	MNIFED	LIG_APCC_ABBA_1	316:321	Mutation substituting flanking lysine	0.25
p.K309N	DO40884	UCEC	ICGC	MNIFED	LIG_APCC_ABBA_1	316:321	Mutation substituting flanking lysine	0.25
p.E308D	TCGA-EO-A22X	UCEC	TCGA	MNIFED	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.1111
p.E308D	DO43907	UCEC	ICGC	MNIFED	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.1111
p.R334W	TCGA-XF-AAN3	BLCA	TCGA	VPSTT	DEG_SPOP_SBC_1	326:330	Mutation rewiring degron network	0.2222
p.R334W	DO219053	BLCA	ICGC	VPSTT	DEG_SPOP_SBC_1	326:330	Mutation rewiring degron network	0.2222
p.I322V	DO233079	GACA	ICGC	VPSTT	DEG_SPOP_SBC_1	326:330	Mutation rewiring degron network	0.2222
p.I322V	DO233079	GACA	ICGC	MNIFED	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.3056
p.I322T	SIDM00985	Burkitt's Lymphoma	GDSC	VPSTT	DEG_SPOP_SBC_1	326:330	Mutation rewiring degron network	0.2222
p.I322T	SIDM00985	Burkitt's Lymphoma	GDSC	MNIFED	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.3056
p.I322T	SIDM00072	Non-Cancerous	GDSC	VPSTT	DEG_SPOP_SBC_1	326:330	Mutation rewiring degron network	0.2222
p.I322T	SIDM00072	Non-Cancerous	GDSC	MNIFED	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.3056
p.I322T	SIDM00812	Colorectal Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	326:330	Mutation rewiring degron network	0.2222
p.I322T	SIDM00812	Colorectal Carcinoma	GDSC	MNIFED	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.3056
p.I322T	SIDM01134	Small Cell Lung Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	326:330	Mutation rewiring degron network	0.2222
p.I322T	SIDM01134	Small Cell Lung Carcinoma	GDSC	MNIFED	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.3056
p.I322T	SIDM00820	Kidney Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	326:330	Mutation rewiring degron network	0.2222
p.I322T	SIDM00820	Kidney Carcinoma	GDSC	MNIFED	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.3056
p.I322T	SIDM00092	Ovarian Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	326:330	Mutation rewiring degron network	0.2222
p.I322T	SIDM00092	Ovarian Carcinoma	GDSC	MNIFED	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.3056
p.I322T	SIDM00195	Ewing's Sarcoma	GDSC	VPSTT	DEG_SPOP_SBC_1	326:330	Mutation rewiring degron network	0.2222
p.I322T	SIDM00195	Ewing's Sarcoma	GDSC	MNIFED	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.3056
p.I322T	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	326:330	Mutation rewiring degron network	0.2222
p.I322T	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	MNIFED	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.3056
p.I322T	SIDM01101	Neuroblastoma	GDSC	VPSTT	DEG_SPOP_SBC_1	326:330	Mutation rewiring degron network	0.2222
p.I322T	SIDM01101	Neuroblastoma	GDSC	MNIFED	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.3056
p.I322T	SIDM00493	Other Solid Cancers	GDSC	VPSTT	DEG_SPOP_SBC_1	326:330	Mutation rewiring degron network	0.2222
p.I322T	SIDM00493	Other Solid Cancers	GDSC	MNIFED	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.3056
p.I322T	SIDM00508	Squamous Cell Lung Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	326:330	Mutation rewiring degron network	0.2222
p.I322T	SIDM00508	Squamous Cell Lung Carcinoma	GDSC	MNIFED	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.3056
p.I322T	SIDM00261	Ewing's Sarcoma	GDSC	VPSTT	DEG_SPOP_SBC_1	326:330	Mutation rewiring degron network	0.2222
p.I322T	SIDM00261	Ewing's Sarcoma	GDSC	MNIFED	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.3056
p.I322T	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPSTT	DEG_SPOP_SBC_1	326:330	Mutation rewiring degron network	0.2222
p.I322T	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	MNIFED	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.3056
p.I322T	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	326:330	Mutation rewiring degron network	0.2222
p.I322T	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	MNIFED	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.3056
p.I322T	SIDM01679	Small Cell Lung Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	326:330	Mutation rewiring degron network	0.2222
p.I322T	SIDM01679	Small Cell Lung Carcinoma	GDSC	MNIFED	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.3056

Kaplan plot for IK in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IK

UniProt ID: Q13123

Entrez ID: 3550

Protein name: Protein Red (Cytokine IK) (IK factor) (Protein RER)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IK in