DegronMD

Uniprot ID: Q13123

Source protein: Protein Red

Source gene: IK

Class: LIG_APCC_ABBA_1

Location: 316:321

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9846

ASA_SCORE: 79.0833

COIL: 0.566

CONS_SCORE: 0.5037

DSS_SCORE: 0.5968

HELIX: 0.339

FCONS_SCORE: 1.2192

RIG_SCORE: 0.7474

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P312T	TCGA-A5-A0G2	UCEC	TCGA	MNIFED	LIG_APCC_ABBA_1	0.2222
p.P312T	DO41235	UCEC	ICGC	MNIFED	LIG_APCC_ABBA_1	0.2222
p.K309N	TCGA-AX-A05Z	UCEC	TCGA	MNIFED	LIG_APCC_ABBA_1	0.25
p.K309N	DO40884	UCEC	ICGC	MNIFED	LIG_APCC_ABBA_1	0.25
p.E308D	TCGA-EO-A22X	UCEC	TCGA	MNIFED	LIG_APCC_ABBA_1	0.1111
p.E308D	DO43907	UCEC	ICGC	MNIFED	LIG_APCC_ABBA_1	0.1111
p.I322V	DO233079	GACA	ICGC	MNIFED	LIG_APCC_ABBA_1	0.3056
p.I322T	SIDM00985	Burkitt's Lymphoma	GDSC	MNIFED	LIG_APCC_ABBA_1	0.3056
p.I322T	SIDM00072	Non-Cancerous	GDSC	MNIFED	LIG_APCC_ABBA_1	0.3056
p.I322T	SIDM00812	Colorectal Carcinoma	GDSC	MNIFED	LIG_APCC_ABBA_1	0.3056
p.I322T	SIDM01134	Small Cell Lung Carcinoma	GDSC	MNIFED	LIG_APCC_ABBA_1	0.3056
p.I322T	SIDM00820	Kidney Carcinoma	GDSC	MNIFED	LIG_APCC_ABBA_1	0.3056
p.I322T	SIDM00092	Ovarian Carcinoma	GDSC	MNIFED	LIG_APCC_ABBA_1	0.3056
p.I322T	SIDM00195	Ewing's Sarcoma	GDSC	MNIFED	LIG_APCC_ABBA_1	0.3056
p.I322T	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	MNIFED	LIG_APCC_ABBA_1	0.3056
p.I322T	SIDM01101	Neuroblastoma	GDSC	MNIFED	LIG_APCC_ABBA_1	0.3056
p.I322T	SIDM00493	Other Solid Cancers	GDSC	MNIFED	LIG_APCC_ABBA_1	0.3056
p.I322T	SIDM00508	Squamous Cell Lung Carcinoma	GDSC	MNIFED	LIG_APCC_ABBA_1	0.3056
p.I322T	SIDM00261	Ewing's Sarcoma	GDSC	MNIFED	LIG_APCC_ABBA_1	0.3056
p.I322T	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	MNIFED	LIG_APCC_ABBA_1	0.3056
p.I322T	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	MNIFED	LIG_APCC_ABBA_1	0.3056
p.I322T	SIDM01679	Small Cell Lung Carcinoma	GDSC	MNIFED	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13123	Protein Red	LIG_APCC_ABBA_1	316:321	MNIFED	APC,CDC20,FZR1	0.9846	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons