DegronMD

Uniprot ID: Q13123

Source protein: Protein Red

Source gene: IK

Class: DEG_SPOP_SBC_1

Location: 326:330

E3 ligase: SPOP

DEGRON score: 0.9958

ASA_SCORE: 77.06

COIL: 0.9084

CONS_SCORE: 0.3971

DSS_SCORE: 0.5933

HELIX: 0.037

FCONS_SCORE: 0.9656

RIG_SCORE: 0.6637

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R334W	TCGA-XF-AAN3	BLCA	TCGA	VPSTT	DEG_SPOP_SBC_1	0.2222
p.R334W	DO219053	BLCA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.I322V	DO233079	GACA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.I322T	SIDM00985	Burkitt's Lymphoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.I322T	SIDM00072	Non-Cancerous	GDSC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.I322T	SIDM00812	Colorectal Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.I322T	SIDM01134	Small Cell Lung Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.I322T	SIDM00820	Kidney Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.I322T	SIDM00092	Ovarian Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.I322T	SIDM00195	Ewing's Sarcoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.I322T	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.I322T	SIDM01101	Neuroblastoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.I322T	SIDM00493	Other Solid Cancers	GDSC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.I322T	SIDM00508	Squamous Cell Lung Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.I322T	SIDM00261	Ewing's Sarcoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.I322T	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.I322T	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.I322T	SIDM01679	Small Cell Lung Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	567:571	VPSTT	SPOP	0.9968	More...
O15020	Spectrin beta chain, non-erythrocytic 2	DEG_SPOP_SBC_1	2342:2346	VPSTT	SPOP	0.9599	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	566:570	VPSTT	SPOP	0.7372	More...
P18583	Protein SON	DEG_SPOP_SBC_1	675:679	VPSTT	SPOP	0.8249	More...
P56975	Pro-neuregulin-3, membrane-bound isoform	DEG_SPOP_SBC_1	193:197	VPSTT	SPOP	0.9767	More...
Q13123	Protein Red	DEG_SPOP_SBC_1	326:330	VPSTT	SPOP	0.9958	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	533:537	VPSTT	SPOP	0.9759	More...
Q1W6H9	Protein FAM110C	DEG_SPOP_SBC_1	280:284	VPSTT	SPOP	0.9945	More...
Q8NEV8	Exophilin-5	DEG_SPOP_SBC_1	900:904	VPSTT	SPOP	0.9989	More...
Q9UH73	Transcription factor COE1	DEG_SPOP_SBC_1	471:475	VPSTT	SPOP	0.9983	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	1004:1008	VPSTT	SPOP	0.8553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons