DegronMD - O15265(ATXN7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L659I	TCGA-A5-A0G2	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.0833
p.L659I	DO41235	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.0833
p.S849N	TCGA-A6-2686	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	841:845	Mutation blocking phosphorylation signal	0.6667
p.S849N	DO7828	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	841:845	Mutation blocking phosphorylation signal	0.6667
p.N848S	TCGA-AJ-A2QO	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	841:845	Mutation rewiring degron network	0.25
p.N848S	DO48395	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	841:845	Mutation rewiring degron network	0.25
p.N848S	DO42177	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	841:845	Mutation rewiring degron network	0.25
p.K838M	TCGA-AX-A2HD	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	841:845	Mutation substituting flanking lysine	0.3611
p.K838M	DO42608	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	841:845	Mutation substituting flanking lysine	0.3611
p.R205H	TCGA-AZ-4315	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.0833
p.R205H	DO8842	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.0833
p.S206Y	TCGA-B5-A1MR	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.1111
p.S206Y	DO41758	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.1111
p.K835N	TCGA-BF-A1Q0	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	841:845	Mutation substituting flanking lysine	0.2778
p.K835N	DO47374	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	841:845	Mutation substituting flanking lysine	0.2778
p.Q693K	TCGA-CJ-5679	KIRC	TCGA	ASSST	DEG_SPOP_SBC_1	695:699	Mutation rewiring degron network	0.2778
p.Q693K	DO18184	KIRC	ICGC	ASSST	DEG_SPOP_SBC_1	695:699	Mutation rewiring degron network	0.2778
p.G687C	TCGA-CN-6010	HNSC	TCGA	ASSST	DEG_SPOP_SBC_1	695:699	Mutation rewiring degron network	0.1111
p.G687C	DO14766	HNSC	ICGC	ASSST	DEG_SPOP_SBC_1	695:699	Mutation rewiring degron network	0.1111
p.C639S	TCGA-D8-A1X6	BRCA	TCGA	VSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1389
p.C639S	DO1683	BRCA	ICGC	VSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1389
p.T235I	TCGA-DF-A2KU	UCEC	TCGA	LQLRGNTR	SCF_FBXL2	229:236	Mutation altering degron motif	0.5966
p.T235I	DO223286	UCEC	ICGC	LQLRGNTR	SCF_FBXL2	229:236	Mutation altering degron motif	0.5966
p.H579Y	TCGA-DX-A6BF	SARC	TCGA	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.0833
p.H579Y	DO219998	SARC	ICGC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.0833
p.S640R	TCGA-EY-A1GU	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1667
p.S640R	DO41518	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1667
p.R707H	TCGA-VQ-A8P2	STAD	TCGA	ASSST	DEG_SPOP_SBC_1	695:699	Mutation rewiring degron network	0.1111
p.R707H	TCGA-VQ-A8P2	STAD	TCGA	VHSSS	DEG_SPOP_SBC_1	715:719	Mutation rewiring degron network	0.1111
p.R707H	DO233624	GACA	ICGC	ASSST	DEG_SPOP_SBC_1	695:699	Mutation rewiring degron network	0.1111
p.R707H	DO233624	GACA	ICGC	VHSSS	DEG_SPOP_SBC_1	715:719	Mutation rewiring degron network	0.1111
p.R707H	DO51761	STAD	ICGC	ASSST	DEG_SPOP_SBC_1	695:699	Mutation rewiring degron network	0.1111
p.R707H	DO51761	STAD	ICGC	VHSSS	DEG_SPOP_SBC_1	715:719	Mutation rewiring degron network	0.1111
p.G834R	TCGA-VQ-A8P2	STAD	TCGA	PSSSS	DEG_SPOP_SBC_1	841:845	Mutation rewiring degron network	0.1389
p.G834R	DO51761	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	841:845	Mutation rewiring degron network	0.1389
p.S850C	DO225360	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	841:845	Mutation rewiring degron network	0.1944
p.R837T	DO1071	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	841:845	Mutation rewiring degron network	0.2222
p.A214T	DO227802	COCA	ICGC	ASSSS	DEG_SPOP_SBC_1	214:218	Mutation altering degron motif	0.7139
p.P565S	DO233230	GACA	ICGC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.3056
p.R205C	DO228244	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.0833
p.I573V	DO228941	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM00215	Colorectal Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM00570	Gastric Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM00435	Acute Myeloid Leukemia	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM00330	Neuroblastoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM00600	Thyroid Gland Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM00496	Thyroid Gland Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM00157	Neuroblastoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM00555	Glioblastoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM00193	Colorectal Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM00465	Ovarian Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM00530	Esophageal Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM00287	B-Lymphoblastic Leukemia	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM00585	Hepatocellular Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM00587	Biliary Tract Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM00489	Oral Cavity Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM00299	Other Sarcomas	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM00242	Osteosarcoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM00574	Glioblastoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM00018	Acute Myeloid Leukemia	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM00618	Hepatocellular Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM01257	Hepatocellular Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM00233	T-Lymphoblastic Leukemia	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM01727	Chronic Myelogenous Leukemia	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM01609	Endometrial Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM01608	Endometrial Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM00167	Head and Neck Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM01781	Gastric Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM00062	Hepatocellular Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM00008	Ovarian Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM01469	Pancreatic Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM01685	B-Lymphoblastic Leukemia	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM01763	Rhabdomyosarcoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.I573V	SIDM01343	Gastric Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.V246F	DO228976	LICA	ICGC	LQLRGNTR	SCF_FBXL2	229:236	Mutation rewiring degron network	0.0556
p.G702C	DO228971	LICA	ICGC	ASSST	DEG_SPOP_SBC_1	695:699	Mutation rewiring degron network	0.25
p.A695S	DO229009	LICA	ICGC	ASSST	DEG_SPOP_SBC_1	695:699	Mutation altering degron motif	0.7588
p.S850N	DO50875	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	841:845	Mutation rewiring degron network	0.1944
p.S696G	DO45207	LIRI	ICGC	ASSST	DEG_SPOP_SBC_1	695:699	Mutation altering degron motif	0.5882
p.M238V	SIDM01034	B-Lymphoblastic Leukemia	GDSC	LQLRGNTR	SCF_FBXL2	229:236	Mutation rewiring degron network	0.2778
p.M238V	ACH-001106	Leukemia	CCLE	LQLRGNTR	SCF_FBXL2	229:236	Mutation rewiring degron network	0.2778
p.M238V	KOPN-8	haematopoietic and lymphoid tissue	COSMIC	LQLRGNTR	SCF_FBXL2	229:236	Mutation rewiring degron network	0.2778
p.R576H	SIDM00984	Other Blood Cancers	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.1667
p.R576H	SIDM00449	B-Lymphoblastic Leukemia	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.1667
p.R576H	SIDM00201	Ewing's Sarcoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.1667
p.Q693H	SIDM00845	Burkitt's Lymphoma	GDSC	ASSST	DEG_SPOP_SBC_1	695:699	Mutation rewiring degron network	0.2778
p.S649L	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.8778
p.S649L	SIDM00210	Ovarian Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.8778
p.S649L	SIDM01133	Other Solid Cancers	GDSC	VSSSS	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.8778
p.R580Q	SIDM00537	Colorectal Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.0556
p.R580Q	ACH-000982	Colon/Colorectal Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.0556
p.R580Q	ACH-001345	Colon/Colorectal Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.0556
p.P565L	SIDM01398	Melanoma	GDSC	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.3056
p.P565L	ACH-000661	Skin Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.3056
p.E243A	OAW-42	ovary	COSMIC	LQLRGNTR	SCF_FBXL2	229:236	Mutation rewiring degron network	0.1389
p.D685E	JAR	placenta	COSMIC	ASSST	DEG_SPOP_SBC_1	695:699	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATXN7

UniProt ID: O15265

Entrez ID: 6314

Protein name: Ataxin-7 (Spinocerebellar ataxia type 7 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATXN7 in