DegronMD

Uniprot ID: O15265

Source protein: Ataxin-7

Source gene: ATXN7

Class: SCF_FBXL2

Location: 229:236

E3 ligase: FBXL2

DEGRON score: 0.9714

ASA_SCORE: 107.85

COIL: 0.77

CONS_SCORE: 0.3807

DSS_SCORE: 0.7608

HELIX: 0.2081

FCONS_SCORE: 1.0004

RIG_SCORE: 0.645

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T235I	TCGA-DF-A2KU	UCEC	TCGA	LQLRGNTR	SCF_FBXL2	0.5966
p.T235I	DO223286	UCEC	ICGC	LQLRGNTR	SCF_FBXL2	0.5966
p.V246F	DO228976	LICA	ICGC	LQLRGNTR	SCF_FBXL2	0.0556
p.M238V	SIDM01034	B-Lymphoblastic Leukemia	GDSC	LQLRGNTR	SCF_FBXL2	0.2778
p.M238V	ACH-001106	Leukemia	CCLE	LQLRGNTR	SCF_FBXL2	0.2778
p.M238V	KOPN-8	haematopoietic_and_lymphoid_tissue	COSMIC	LQLRGNTR	SCF_FBXL2	0.2778
p.E243A	OAW-42	ovary	COSMIC	LQLRGNTR	SCF_FBXL2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15265	Ataxin-7	SCF_FBXL2	229:236	LQLRGNTR	FBXL2	0.9714	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons