DegronMD

Uniprot ID: O15265

Source protein: Ataxin-7

Source gene: ATXN7

Class: DEG_SPOP_SBC_1

Location: 566:570

E3 ligase: SPOP

DEGRON score: 0.7372

ASA_SCORE: 94.5

COIL: 0.9506

CONS_SCORE: 0.3103

DSS_SCORE: 0.4374

HELIX: 0.0196

FCONS_SCORE: 0.7979

RIG_SCORE: 0.6721

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H579Y	TCGA-DX-A6BF	SARC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.0833
p.H579Y	DO219998	SARC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.0833
p.P565S	DO233230	GACA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.3056
p.I573V	DO228941	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM00215	Colorectal Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM00570	Gastric Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM00435	Acute Myeloid Leukemia	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM00330	Neuroblastoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM00600	Thyroid Gland Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM00496	Thyroid Gland Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM00157	Neuroblastoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM00555	Glioblastoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM00193	Colorectal Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM00465	Ovarian Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM00530	Esophageal Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM00287	B-Lymphoblastic Leukemia	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM00585	Hepatocellular Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM00587	Biliary Tract Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM00489	Oral Cavity Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM00299	Other Sarcomas	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM00242	Osteosarcoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM00574	Glioblastoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM00018	Acute Myeloid Leukemia	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM00618	Hepatocellular Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM01257	Hepatocellular Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM00233	T-Lymphoblastic Leukemia	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM01727	Chronic Myelogenous Leukemia	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM01609	Endometrial Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM01608	Endometrial Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM00167	Head and Neck Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM01781	Gastric Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM00062	Hepatocellular Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM00008	Ovarian Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM01469	Pancreatic Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM01685	B-Lymphoblastic Leukemia	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM01763	Rhabdomyosarcoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.I573V	SIDM01343	Gastric Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.25
p.R576H	SIDM00984	Other Blood Cancers	GDSC	VPSTT	DEG_SPOP_SBC_1	0.1667
p.R576H	SIDM00449	B-Lymphoblastic Leukemia	GDSC	VPSTT	DEG_SPOP_SBC_1	0.1667
p.R576H	SIDM00201	Ewing's Sarcoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.1667
p.R580Q	SIDM00537	Colorectal Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.0556
p.R580Q	ACH-000982	Colon/Colorectal Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	0.0556
p.R580Q	ACH-001345	Colon/Colorectal Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	0.0556
p.P565L	SIDM01398	Melanoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.3056
p.P565L	ACH-000661	Skin Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	567:571	VPSTT	SPOP	0.9968	More...
O15020	Spectrin beta chain, non-erythrocytic 2	DEG_SPOP_SBC_1	2342:2346	VPSTT	SPOP	0.9599	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	566:570	VPSTT	SPOP	0.7372	More...
P18583	Protein SON	DEG_SPOP_SBC_1	675:679	VPSTT	SPOP	0.8249	More...
P56975	Pro-neuregulin-3, membrane-bound isoform	DEG_SPOP_SBC_1	193:197	VPSTT	SPOP	0.9767	More...
Q13123	Protein Red	DEG_SPOP_SBC_1	326:330	VPSTT	SPOP	0.9958	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	533:537	VPSTT	SPOP	0.9759	More...
Q1W6H9	Protein FAM110C	DEG_SPOP_SBC_1	280:284	VPSTT	SPOP	0.9945	More...
Q8NEV8	Exophilin-5	DEG_SPOP_SBC_1	900:904	VPSTT	SPOP	0.9989	More...
Q9UH73	Transcription factor COE1	DEG_SPOP_SBC_1	471:475	VPSTT	SPOP	0.9983	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	1004:1008	VPSTT	SPOP	0.8553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPSTT

Degron related mutations and impact score

Drug responses associated with ATXN7 mutations

All proteins holding degron of VPSTT