DegronMD - Q9UH73(EBF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V471L	TCGA-39-5011	LUSC	TCGA	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation altering degron motif	0.6765
p.V471L	DO27532	LUSC	ICGC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation altering degron motif	0.6765
p.P519T	TCGA-85-6560	LUSC	TCGA	ASSTS	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.1667
p.P519T	SIDM02050	Colorectal Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.1667
p.L530I	TCGA-CG-5721	STAD	TCGA	ASSTS	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.3056
p.L530I	TCGA-SJ-A6ZI	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.3056
p.S521R	TCGA-CK-4951	COAD	TCGA	ASSTS	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.2222
p.P472S	TCGA-CV-7568	HNSC	TCGA	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation altering degron motif	0.5641
p.P472S	DO14160	HNSC	ICGC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation altering degron motif	0.5641
p.N533T	TCGA-D8-A1JP	BRCA	TCGA	ASSTS	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.2222
p.G469R	TCGA-DI-A1BU	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.2778
p.G469R	DO42023	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.2778
p.P472L	TCGA-DK-AA6U	BLCA	TCGA	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation altering degron motif	0.6471
p.P472L	DO219008	BLCA	ICGC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation altering degron motif	0.6471
p.P476S	TCGA-DK-AA77	BLCA	TCGA	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.3056
p.P476S	DO219014	BLCA	ICGC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.3056
p.V465I	TCGA-EO-A22U	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.1667
p.V465I	DO43755	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.1667
p.S466L	TCGA-EW-A1J5	BRCA	TCGA	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.1944
p.S466L	DO6144	BRCA	ICGC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.1944
p.G469W	TCGA-FS-A1ZP	SKCM	TCGA	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.2778
p.G469W	DO37703	SKCM	ICGC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.2778
p.S536N	TCGA-G3-A7M6	LIHC	TCGA	ASSTS	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.1389
p.V471M	TCGA-R5-A7ZI	STAD	TCGA	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation altering degron motif	0.7208
p.V471M	DO222342	STAD	ICGC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation altering degron motif	0.7208
p.N465T	DO5857	BRCA	ICGC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.1667
p.F473L	DO7783	COAD	ICGC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation altering degron motif	0.6981
p.V484I	DO227549	COCA	ICGC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.0833
p.V484I	DO34544	PACA	ICGC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.0833
p.V484I	SIDM00683	Prostate Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.0833
p.V484I	SIDM00882	Breast Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.0833
p.V484I	HCC1419	breast	COSMIC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.0833
p.V484M	DO234185	ESAD	ICGC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.0833
p.A478V	DO218769	GACA	ICGC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.25
p.A483D	DO228971	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.1111
p.P467Q	DO229029	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.2222
p.G469E	DO229050	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.2778
p.S468N	DO52291	LIHC	ICGC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.25
p.S470L	DO222875	MELA	ICGC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.3056
p.P521S	DO222837	MELA	ICGC	ASSTS	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.2222
p.S463N	DO46329	OV	ICGC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.1111
p.L462I	DO38192	STAD	ICGC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.0833
p.L462I	DO219784	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.0833
p.C466F	DO229229	THCA	ICGC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.1944
p.N533Y	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.2222
p.V471A	ACH-000997	Colon/Colorectal Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation altering degron motif	0.5825
p.V471A	ACH-001061	Colon/Colorectal Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation altering degron motif	0.5825
p.V471A	HCT-15	large intestine	COSMIC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation altering degron motif	0.5825
p.T523I	ACH-001274	Sarcoma	CCLE	ASSTS	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.2778
p.G461S	Mewo	skin	COSMIC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.0556
p.G461D	Mewo	skin	COSMIC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.0556
p.P472T	22RV1	prostate	COSMIC	VPSTT	DEG_SPOP_SBC_1	471:475	Mutation altering degron motif	0.5919

Kaplan plot for EBF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EBF1

UniProt ID: Q9UH73

Entrez ID: 1879

Protein name: Transcription factor COE1 (O/E-1) (OE-1) (Early B-cell factor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EBF1 in