DegronMD

Uniprot ID: Q9UH73

Source protein: Transcription factor COE1

Source gene: EBF1

Class: DEG_SPOP_SBC_1

Location: 471:475

E3 ligase: SPOP

DEGRON score: 0.9983

ASA_SCORE: 75.9

COIL: 0.9298

CONS_SCORE: 0.4303

DSS_SCORE: 0.5897

HELIX: 0.0166

FCONS_SCORE: 1.1221

RIG_SCORE: 0.6542

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V471L	TCGA-39-5011	LUSC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.6765
p.V471L	DO27532	LUSC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.6765
p.P472S	TCGA-CV-7568	HNSC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.5641
p.P472S	DO14160	HNSC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.5641
p.G469R	TCGA-DI-A1BU	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.2778
p.G469R	DO42023	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.2778
p.P472L	TCGA-DK-AA6U	BLCA	TCGA	VPSTT	DEG_SPOP_SBC_1	0.6471
p.P472L	DO219008	BLCA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.6471
p.P476S	TCGA-DK-AA77	BLCA	TCGA	VPSTT	DEG_SPOP_SBC_1	0.3056
p.P476S	DO219014	BLCA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.3056
p.V465I	TCGA-EO-A22U	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.1667
p.V465I	DO43755	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1667
p.S466L	TCGA-EW-A1J5	BRCA	TCGA	VPSTT	DEG_SPOP_SBC_1	0.1944
p.S466L	DO6144	BRCA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1944
p.G469W	TCGA-FS-A1ZP	SKCM	TCGA	VPSTT	DEG_SPOP_SBC_1	0.2778
p.G469W	DO37703	SKCM	ICGC	VPSTT	DEG_SPOP_SBC_1	0.2778
p.V471M	TCGA-R5-A7ZI	STAD	TCGA	VPSTT	DEG_SPOP_SBC_1	0.7208
p.V471M	DO222342	STAD	ICGC	VPSTT	DEG_SPOP_SBC_1	0.7208
p.N465T	DO5857	BRCA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1667
p.F473L	DO7783	COAD	ICGC	VPSTT	DEG_SPOP_SBC_1	0.6981
p.V484I	DO227549	COCA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.0833
p.V484I	DO34544	PACA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.0833
p.V484I	SIDM00683	Prostate Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.0833
p.V484I	SIDM00882	Breast Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.0833
p.V484I	HCC1419	breast	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.0833
p.V484M	DO234185	ESAD	ICGC	VPSTT	DEG_SPOP_SBC_1	0.0833
p.A478V	DO218769	GACA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.25
p.A483D	DO228971	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1111
p.P467Q	DO229029	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.G469E	DO229050	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.2778
p.S468N	DO52291	LIHC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.25
p.S470L	DO222875	MELA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.3056
p.S463N	DO46329	OV	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1111
p.L462I	DO38192	STAD	ICGC	VPSTT	DEG_SPOP_SBC_1	0.0833
p.L462I	DO219784	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.0833
p.C466F	DO229229	THCA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1944
p.V471A	ACH-000997	Colon/Colorectal Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	0.5825
p.V471A	ACH-001061	Colon/Colorectal Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	0.5825
p.V471A	HCT-15	large_intestine	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.5825
p.G461S	Mewo	skin	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.0556
p.G461D	Mewo	skin	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.0556
p.P472T	22RV1	prostate	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.5919

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	567:571	VPSTT	SPOP	0.9968	More...
O15020	Spectrin beta chain, non-erythrocytic 2	DEG_SPOP_SBC_1	2342:2346	VPSTT	SPOP	0.9599	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	566:570	VPSTT	SPOP	0.7372	More...
P18583	Protein SON	DEG_SPOP_SBC_1	675:679	VPSTT	SPOP	0.8249	More...
P56975	Pro-neuregulin-3, membrane-bound isoform	DEG_SPOP_SBC_1	193:197	VPSTT	SPOP	0.9767	More...
Q13123	Protein Red	DEG_SPOP_SBC_1	326:330	VPSTT	SPOP	0.9958	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	533:537	VPSTT	SPOP	0.9759	More...
Q1W6H9	Protein FAM110C	DEG_SPOP_SBC_1	280:284	VPSTT	SPOP	0.9945	More...
Q8NEV8	Exophilin-5	DEG_SPOP_SBC_1	900:904	VPSTT	SPOP	0.9989	More...
Q9UH73	Transcription factor COE1	DEG_SPOP_SBC_1	471:475	VPSTT	SPOP	0.9983	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	1004:1008	VPSTT	SPOP	0.8553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPSTT

Degron related mutations and impact score

Drug responses associated with EBF1 mutations

All proteins holding degron of VPSTT