DegronMD - Q1W6H9(FAM110C)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I277M	TCGA-AA-3984	COAD	TCGA	VPSTT	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.25
p.I277M	DO9002	COAD	ICGC	VPSTT	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.25
p.S282I	TCGA-AP-A0LM	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	280:284	Mutation altering degron motif	0.7341
p.S282I	DO43306	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	280:284	Mutation altering degron motif	0.7341
p.R292H	TCGA-AZ-4315	COAD	TCGA	VPSTT	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.1111
p.R292H	DO8842	COAD	ICGC	VPSTT	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.1111
p.S285L	TCGA-DK-AA75	BLCA	TCGA	VPSTT	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.3056
p.S285L	DO48364	BLCA	ICGC	VPSTT	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.3056
p.S285L	DO219012	BLCA	ICGC	VPSTT	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.3056
p.Q279K	TCGA-EY-A1GX	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.3056
p.Q279K	DO41967	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.3056
p.G270R	TCGA-FR-A726	SKCM	TCGA	VPSTT	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.0556
p.G270R	DO48665	SKCM	ICGC	VPSTT	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.0556
p.P281T	SIDM01073	Other Blood Cancers	GDSC	VPSTT	DEG_SPOP_SBC_1	280:284	Mutation altering degron motif	0.5919
p.P281T	ACH-002242	Leukemia	CCLE	VPSTT	DEG_SPOP_SBC_1	280:284	Mutation altering degron motif	0.5919
p.P281T	HC-1	haematopoietic and lymphoid tissue	COSMIC	VPSTT	DEG_SPOP_SBC_1	280:284	Mutation altering degron motif	0.5919

Kaplan plot for FAM110C in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM110C

UniProt ID: Q1W6H9

Entrez ID: 642273

Protein name: Protein FAM110C

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM110C in