DegronMD

Uniprot ID: Q1W6H9

Source protein: Protein FAM110C

Source gene: FAM110C

Class: DEG_SPOP_SBC_1

Location: 280:284

E3 ligase: SPOP

DEGRON score: 0.9945

ASA_SCORE: 61.32

COIL: 0.8916

CONS_SCORE: 0.5787

DSS_SCORE: 0.4668

HELIX: 0.0368

FCONS_SCORE: 0.7458

RIG_SCORE: 0.7837

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I277M	TCGA-AA-3984	COAD	TCGA	VPSTT	DEG_SPOP_SBC_1	0.25
p.I277M	DO9002	COAD	ICGC	VPSTT	DEG_SPOP_SBC_1	0.25
p.S282I	TCGA-AP-A0LM	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.7341
p.S282I	DO43306	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.7341
p.R292H	TCGA-AZ-4315	COAD	TCGA	VPSTT	DEG_SPOP_SBC_1	0.1111
p.R292H	DO8842	COAD	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1111
p.S285L	TCGA-DK-AA75	BLCA	TCGA	VPSTT	DEG_SPOP_SBC_1	0.3056
p.S285L	DO48364	BLCA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.3056
p.S285L	DO219012	BLCA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.3056
p.Q279K	TCGA-EY-A1GX	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.3056
p.Q279K	DO41967	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.3056
p.G270R	TCGA-FR-A726	SKCM	TCGA	VPSTT	DEG_SPOP_SBC_1	0.0556
p.G270R	DO48665	SKCM	ICGC	VPSTT	DEG_SPOP_SBC_1	0.0556
p.P281T	SIDM01073	Other Blood Cancers	GDSC	VPSTT	DEG_SPOP_SBC_1	0.5919
p.P281T	ACH-002242	Leukemia	CCLE	VPSTT	DEG_SPOP_SBC_1	0.5919
p.P281T	HC-1	haematopoietic_and_lymphoid_tissue	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.5919

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	567:571	VPSTT	SPOP	0.9968	More...
O15020	Spectrin beta chain, non-erythrocytic 2	DEG_SPOP_SBC_1	2342:2346	VPSTT	SPOP	0.9599	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	566:570	VPSTT	SPOP	0.7372	More...
P18583	Protein SON	DEG_SPOP_SBC_1	675:679	VPSTT	SPOP	0.8249	More...
P56975	Pro-neuregulin-3, membrane-bound isoform	DEG_SPOP_SBC_1	193:197	VPSTT	SPOP	0.9767	More...
Q13123	Protein Red	DEG_SPOP_SBC_1	326:330	VPSTT	SPOP	0.9958	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	533:537	VPSTT	SPOP	0.9759	More...
Q1W6H9	Protein FAM110C	DEG_SPOP_SBC_1	280:284	VPSTT	SPOP	0.9945	More...
Q8NEV8	Exophilin-5	DEG_SPOP_SBC_1	900:904	VPSTT	SPOP	0.9989	More...
Q9UH73	Transcription factor COE1	DEG_SPOP_SBC_1	471:475	VPSTT	SPOP	0.9983	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	1004:1008	VPSTT	SPOP	0.8553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons