DegronMD

Uniprot ID: P56975

Source protein: Pro-neuregulin-3, membrane-bound isoform

Source gene: NRG3

Class: DEG_SPOP_SBC_1

Location: 193:197

E3 ligase: SPOP

DEGRON score: 0.9767

ASA_SCORE: 70.12

COIL: 0.8972

CONS_SCORE: 0.3416

DSS_SCORE: 0.5505

HELIX: 0.0246

FCONS_SCORE: 0.9196

RIG_SCORE: 0.678

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S204R	TCGA-34-2609	LUSC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.1389
p.S204R	TCGA-DD-A4NF	LIHC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.1389
p.S204R	DO44950	LIHC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1389
p.S204R	DO26981	LUSC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1389
p.A188V	TCGA-AJ-A3EL	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.1944
p.A188V	TCGA-E6-A1LX	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.1944
p.A188V	DO41020	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1944
p.A188V	DO41542	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1944
p.P199L	TCGA-AX-A1CE	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.2778
p.P199L	DO42280	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.2778
p.R185W	TCGA-BR-4184	STAD	TCGA	VPSTT	DEG_SPOP_SBC_1	0.1111
p.R185W	DO38328	STAD	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1111
p.T205M	TCGA-CM-5348	COAD	TCGA	VPSTT	DEG_SPOP_SBC_1	0.1111
p.T205M	TCGA-JY-A6F8	ESCA	TCGA	VPSTT	DEG_SPOP_SBC_1	0.1111
p.T205M	DO9514	COAD	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1111
p.S203C	TCGA-D6-A4Z9	HNSC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.1667
p.S203C	DO44419	HNSC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1667
p.A189S	TCGA-NC-A5HI	LUSC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.2222
p.A189S	DO45461	LUSC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.A191S	TCGA-T3-A92N	HNSC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.2778
p.A191S	DO219073	HNSC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.2778
p.A191V	TCGA-VQ-A927	STAD	TCGA	VPSTT	DEG_SPOP_SBC_1	0.2778
p.A191V	DO234415	ESAD	ICGC	VPSTT	DEG_SPOP_SBC_1	0.2778
p.A191V	DO51797	STAD	ICGC	VPSTT	DEG_SPOP_SBC_1	0.2778
p.L186P	DO223359	CLLE	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1389
p.L186P	DO222755	COCA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1389
p.L186P	DO49418	PACA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1389
p.L186P	DO38591	STAD	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1389
p.T197M	DO234230	ESAD	ICGC	VPSTT	DEG_SPOP_SBC_1	0.7423
p.N186K	DO233270	GACA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1389
p.T192M	DO233202	GACA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.3056
p.A198S	DO233747	GACA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.3056
p.A198S	DO229029	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.3056
p.A198S	DO229026	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.3056
p.K200N	DO233864	GACA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.25
p.A188S	DO228976	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1944
p.V199L	DO229019	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.2778
p.G207V	DO229031	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.0556
p.K194N	DO229045	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.6918
p.P190T	DO23410	LINC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.25
p.R185Q	DO229177	LMS	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1111
p.R185Q	SIDM01439	Hepatocellular Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.1111
p.R185Q	ACH-000537	Liver Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	0.1111
p.M192I	DO45425	LUSC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.3056
p.L205Q	DO228797	PBCA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1111
p.A188T	DO42023	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1944
p.S203G	SIDM00491	Thyroid Gland Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.1667
p.S203G	ACH-001443	Thyroid Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	0.1667
p.S203G	ASH-3	thyroid	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.1667
p.A191T	SIDM00596	Endometrial Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.2778
p.A191T	ACH-000941	Endometrial/Uterine Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	0.2778
p.A191T	ACH-000954	Endometrial/Uterine Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	0.2778
p.A191T	ACH-001517	Endometrial/Uterine Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	0.2778
p.A191T	HEC-1	endometrium	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.2778
p.P194S	SIDM00886	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.5641
p.P194S	ACH-000334	Lymphoma	CCLE	VPSTT	DEG_SPOP_SBC_1	0.5641
p.P194S	DB	haematopoietic_and_lymphoid_tissue	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.5641
p.A189D	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.A189D	ACH-000627	Lung Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	0.2222
p.A189D	LCLC-103H	lung	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.P199T	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.2778
p.P199T	ACH-000553	Lung Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	0.2778
p.Q190K	LOUCY	haematopoietic_and_lymphoid_tissue	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.25
p.S207R	NCI-H520	lung	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.0556
p.P197H	NCI-H1573	lung	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.7694
p.V191M	NCI-H358	lung	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.2778
p.K207N	NCI-H226	lung	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.0556
p.E185D	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.1111
p.S190I	SNU-1040	large_intestine	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.25
p.A193T	OC-314	ovary	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.7139
p.L200P	HCT-116	large_intestine	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	567:571	VPSTT	SPOP	0.9968	More...
O15020	Spectrin beta chain, non-erythrocytic 2	DEG_SPOP_SBC_1	2342:2346	VPSTT	SPOP	0.9599	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	566:570	VPSTT	SPOP	0.7372	More...
P18583	Protein SON	DEG_SPOP_SBC_1	675:679	VPSTT	SPOP	0.8249	More...
P56975	Pro-neuregulin-3, membrane-bound isoform	DEG_SPOP_SBC_1	193:197	VPSTT	SPOP	0.9767	More...
Q13123	Protein Red	DEG_SPOP_SBC_1	326:330	VPSTT	SPOP	0.9958	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	533:537	VPSTT	SPOP	0.9759	More...
Q1W6H9	Protein FAM110C	DEG_SPOP_SBC_1	280:284	VPSTT	SPOP	0.9945	More...
Q8NEV8	Exophilin-5	DEG_SPOP_SBC_1	900:904	VPSTT	SPOP	0.9989	More...
Q9UH73	Transcription factor COE1	DEG_SPOP_SBC_1	471:475	VPSTT	SPOP	0.9983	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	1004:1008	VPSTT	SPOP	0.8553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPSTT

Degron related mutations and impact score

Drug responses associated with NRG3 mutations

All proteins holding degron of VPSTT