DegronMD - Q8NEV8(EXPH5)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V106I	TCGA-06-5416	GBM	TCGA	PTPFSS	DEG_SCF_FBW7_1	112:117	Mutation rewiring degron network	0.1667
p.R1793H	TCGA-19-5956	GBM	TCGA	INVHGD	LIG_APCC_ABBA_1	1800:1805	Mutation rewiring degron network	0.1389
p.R1793H	SIDM00176	Chondrosarcoma	GDSC	INVHGD	LIG_APCC_ABBA_1	1800:1805	Mutation rewiring degron network	0.1389
p.R1793H	ACH-002094	Bone Cancer	CCLE	INVHGD	LIG_APCC_ABBA_1	1800:1805	Mutation rewiring degron network	0.1389
p.R1793H	CHSA8926	bone	COSMIC	INVHGD	LIG_APCC_ABBA_1	1800:1805	Mutation rewiring degron network	0.1389
p.R1222L	TCGA-22-4595	LUSC	TCGA	VKTTS	DEG_SPOP_SBC_1	1229:1233	Mutation rewiring degron network	0.1389
p.F287S	TCGA-25-2401	OV	TCGA	PRTST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.2778
p.P1952A	TCGA-75-6214	LUAD	TCGA	LNIYED	LIG_APCC_ABBA_1	1956:1961	Mutation rewiring degron network	0.2222
p.S369L	TCGA-A5-A0G1	UCEC	TCGA	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation altering degron motif	0.6556
p.S369L	TCGA-A5-A0G1	UCEC	TCGA	PKRTPLSS	DEG_SCF_FBW7_1	363:370	Mutation altering degron motif	0.6556
p.S369L	Daoy	central nervous system	COSMIC	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation altering degron motif	0.6556
p.S369L	Daoy	central nervous system	COSMIC	PKRTPLSS	DEG_SCF_FBW7_1	363:370	Mutation altering degron motif	0.6556
p.P901L	TCGA-AO-A0JA	BRCA	TCGA	VPSTT	DEG_SPOP_SBC_1	900:904	Mutation altering degron motif	0.6471
p.D381Y	TCGA-AP-A1DV	UCEC	TCGA	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.0833
p.S1174Y	TCGA-AP-A1E0	UCEC	TCGA	QKENF	DEG_APCC_KENBOX_2	1181:1185	Mutation rewiring degron network	0.1389
p.F906L	TCGA-BP-5182	KIRC	TCGA	VPSTT	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.2778
p.S902T	TCGA-BR-7723	STAD	TCGA	VPSTT	DEG_SPOP_SBC_1	900:904	Mutation altering degron motif	0.7116
p.R365I	TCGA-BS-A0UV	UCEC	TCGA	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation altering degron motif	0.8102
p.R365I	TCGA-BS-A0UV	UCEC	TCGA	PKRTPLSS	DEG_SCF_FBW7_1	363:370	Mutation altering degron motif	0.6991
p.R365I	SIDM01588	Endometrial Carcinoma	GDSC	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation altering degron motif	0.8102
p.R365I	SIDM01588	Endometrial Carcinoma	GDSC	PKRTPLSS	DEG_SCF_FBW7_1	363:370	Mutation altering degron motif	0.6991
p.R365I	ACH-000993	Endometrial/Uterine Cancer	CCLE	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation altering degron motif	0.8102
p.R365I	ACH-000993	Endometrial/Uterine Cancer	CCLE	PKRTPLSS	DEG_SCF_FBW7_1	363:370	Mutation altering degron motif	0.6991
p.D1969H	TCGA-C5-A902	CESC	TCGA	LNIYED	LIG_APCC_ABBA_1	1956:1961	Mutation rewiring degron network	0.1111
p.D896G	TCGA-C8-A8HR	BRCA	TCGA	VPSTT	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.2222
p.P289A	TCGA-CN-6998	HNSC	TCGA	PRTST	DEG_SPOP_SBC_1	289:293	Mutation altering degron motif	0.6392
p.Y1959C	TCGA-CR-7383	HNSC	TCGA	LNIYED	LIG_APCC_ABBA_1	1956:1961	Mutation altering degron motif	0.7087
p.G283D	TCGA-D3-A8GI	SKCM	TCGA	PRTST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1667
p.P911L	TCGA-D3-A8GR	SKCM	TCGA	VPSTT	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.1389
p.N1967I	TCGA-D8-A1XK	BRCA	TCGA	LNIYED	LIG_APCC_ABBA_1	1956:1961	Mutation rewiring degron network	0.1667
p.S1236F	TCGA-DK-A3WW	BLCA	TCGA	VKTTS	DEG_SPOP_SBC_1	1229:1233	Mutation rewiring degron network	0.25
p.T1234R	TCGA-DU-6402	LGG	TCGA	VKTTS	DEG_SPOP_SBC_1	1229:1233	Mutation rewiring degron network	0.3056
p.R301M	TCGA-EE-A2MD	SKCM	TCGA	PRTST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1111
p.R102K	TCGA-ER-A193	SKCM	TCGA	PTPFSS	DEG_SCF_FBW7_1	112:117	Mutation rewiring degron network	0.0556
p.K1194T	TCGA-EY-A1GD	UCEC	TCGA	QKENF	DEG_APCC_KENBOX_2	1181:1185	Mutation substituting flanking lysine	0.1944
p.H1790Q	TCGA-HT-7689	LGG	TCGA	INVHGD	LIG_APCC_ABBA_1	1800:1805	Mutation rewiring degron network	0.0556
p.S379C	TCGA-K4-A54R	BLCA	TCGA	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.1389
p.S379C	TCGA-K4-A54R	BLCA	TCGA	PKRTPLSS	DEG_SCF_FBW7_1	363:370	Mutation rewiring degron network	0.0833
p.D1805N	TCGA-W3-AA1R	SKCM	TCGA	INVHGD	LIG_APCC_ABBA_1	1800:1805	Mutation altering degron motif	0.6932
p.D1805N	SIDM00534	Colorectal Carcinoma	GDSC	INVHGD	LIG_APCC_ABBA_1	1800:1805	Mutation altering degron motif	0.6932
p.D1805N	SIDM01588	Endometrial Carcinoma	GDSC	INVHGD	LIG_APCC_ABBA_1	1800:1805	Mutation altering degron motif	0.6932
p.D1805N	ACH-000986	Colon/Colorectal Cancer	CCLE	INVHGD	LIG_APCC_ABBA_1	1800:1805	Mutation altering degron motif	0.6932
p.D1805N	ACH-000993	Endometrial/Uterine Cancer	CCLE	INVHGD	LIG_APCC_ABBA_1	1800:1805	Mutation altering degron motif	0.6932
p.D1805N	HT-115	large intestine	COSMIC	INVHGD	LIG_APCC_ABBA_1	1800:1805	Mutation altering degron motif	0.6932
p.S379F	TCGA-XF-A9T6	BLCA	TCGA	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.1389
p.S379F	TCGA-XF-A9T6	BLCA	TCGA	PKRTPLSS	DEG_SCF_FBW7_1	363:370	Mutation rewiring degron network	0.0833
p.R355I	DO2401	BRCA	ICGC	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.0833
p.R355I	DO2401	BRCA	ICGC	PKRTPLSS	DEG_SCF_FBW7_1	363:370	Mutation rewiring degron network	0.1111
p.E1219K	DO9002	COAD	ICGC	VKTTS	DEG_SPOP_SBC_1	1229:1233	Mutation rewiring degron network	0.0556
p.N891I	DO7798	COAD	ICGC	VPSTT	DEG_SPOP_SBC_1	900:904	Mutation substituting flanking lysine	0.1944
p.K1185R	DO8264	COAD	ICGC	QKENF	DEG_APCC_KENBOX_2	1181:1185	Mutation altering degron motif	0.7237
p.E114V	DO227990	COCA	ICGC	PTPFSS	DEG_SCF_FBW7_1	112:117	Mutation altering degron motif	0.7693
p.S300Y	DO222884	COCA	ICGC	PRTST	DEG_SPOP_SBC_1	289:293	Mutation blocking phosphorylation signal	0.5833
p.T912A	DO50388	ESAD	ICGC	VPSTT	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.1111
p.P362H	DO233731	GACA	ICGC	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation blocking phosphorylation signal	0.7222
p.P362H	DO233731	GACA	ICGC	PKRTPLSS	DEG_SCF_FBW7_1	363:370	Mutation blocking phosphorylation signal	0.75
p.R910I	DO10880	GBM	ICGC	VPSTT	DEG_SPOP_SBC_1	900:904	Mutation blocking phosphorylation signal	0.6111
p.G288V	DO10880	GBM	ICGC	PRTST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.3056
p.G282R	DO44517	KIRP	ICGC	PRTST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1389
p.T371K	DO228971	LICA	ICGC	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation altering degron motif	0.7306
p.D103E	DO229032	LICA	ICGC	PTPFSS	DEG_SCF_FBW7_1	112:117	Mutation rewiring degron network	0.0833
p.S374R	DO229031	LICA	ICGC	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.2778
p.S374R	DO229031	LICA	ICGC	PKRTPLSS	DEG_SCF_FBW7_1	363:370	Mutation rewiring degron network	0.2222
p.Q295K	DO229045	LICA	ICGC	PRTST	DEG_SPOP_SBC_1	289:293	Mutation blocking phosphorylation signal	0.7222
p.E359V	DO231518	LINC	ICGC	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.1944
p.E359V	DO231518	LINC	ICGC	PKRTPLSS	DEG_SCF_FBW7_1	363:370	Mutation rewiring degron network	0.2222
p.D1190H	DO23597	LUAD	ICGC	QKENF	DEG_APCC_KENBOX_2	1181:1185	Mutation rewiring degron network	0.1944
p.A1184G	DO231127	LUSC	ICGC	QKENF	DEG_APCC_KENBOX_2	1181:1185	Mutation altering degron motif	0.754
p.S898L	DO26578	LUSC	ICGC	VPSTT	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.2778
p.P1236S	DO220913	MELA	ICGC	VKTTS	DEG_SPOP_SBC_1	1229:1233	Mutation rewiring degron network	0.25
p.S1237F	DO28014	OV	ICGC	VKTTS	DEG_SPOP_SBC_1	1229:1233	Mutation rewiring degron network	0.2222
p.A1175D	DO46657	PAAD	ICGC	QKENF	DEG_APCC_KENBOX_2	1181:1185	Mutation rewiring degron network	0.1667
p.S281R	DO224724	PACA	ICGC	PRTST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1111
p.T127I	DO232224	PBCA	ICGC	PTPFSS	DEG_SCF_FBW7_1	112:117	Mutation rewiring degron network	0.0556
p.E892D	DO51124	PRAD	ICGC	VPSTT	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.1111
p.P1187H	DO51407	PRAD	ICGC	QKENF	DEG_APCC_KENBOX_2	1181:1185	Mutation rewiring degron network	0.2778
p.P1187H	DO42673	UCEC	ICGC	QKENF	DEG_APCC_KENBOX_2	1181:1185	Mutation rewiring degron network	0.2778
p.R113M	DO37851	SKCM	ICGC	PTPFSS	DEG_SCF_FBW7_1	112:117	Mutation altering degron motif	0.8632
p.G298E	DO37831	SKCM	ICGC	PRTST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1944
p.G298E	DO47331	SKCM	ICGC	PRTST	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1944
p.M375I	DO37782	SKCM	ICGC	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.25
p.M375I	DO37782	SKCM	ICGC	PKRTPLSS	DEG_SCF_FBW7_1	363:370	Mutation rewiring degron network	0.1944
p.G380C	DO37480	SKCM	ICGC	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.1111
p.G380C	DO37480	SKCM	ICGC	PKRTPLSS	DEG_SCF_FBW7_1	363:370	Mutation rewiring degron network	0.0556
p.P108T	DO50278	SKCM	ICGC	PTPFSS	DEG_SCF_FBW7_1	112:117	Mutation rewiring degron network	0.2222
p.Q368H	DO37961	SKCM	ICGC	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation altering degron motif	0.7582
p.Q368H	DO37961	SKCM	ICGC	PKRTPLSS	DEG_SCF_FBW7_1	363:370	Mutation altering degron motif	0.7582
p.W293C	DO47683	SKCM	ICGC	PRTST	DEG_SPOP_SBC_1	289:293	Mutation altering degron motif	0.7
p.P108Q	DO47607	SKCM	ICGC	PTPFSS	DEG_SCF_FBW7_1	112:117	Mutation rewiring degron network	0.2222
p.E358D	DO40884	UCEC	ICGC	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.1667
p.E358D	DO40884	UCEC	ICGC	PKRTPLSS	DEG_SCF_FBW7_1	363:370	Mutation rewiring degron network	0.1944
p.E359Q	DO43033	UCEC	ICGC	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.1944
p.E359Q	DO43033	UCEC	ICGC	PKRTPLSS	DEG_SCF_FBW7_1	363:370	Mutation rewiring degron network	0.2222
p.E1177D	DO41133	UCEC	ICGC	QKENF	DEG_APCC_KENBOX_2	1181:1185	Mutation substituting flanking lysine	0.3333
p.E1794G	DO42793	UCEC	ICGC	INVHGD	LIG_APCC_ABBA_1	1800:1805	Mutation rewiring degron network	0.1667
p.R382M	SIDM02021	Esophageal Carcinoma	GDSC	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.0556
p.S127F	SIDM01261	Breast Carcinoma	GDSC	PTPFSS	DEG_SCF_FBW7_1	112:117	Mutation rewiring degron network	0.0556
p.S127F	SIDM00314	Breast Carcinoma	GDSC	PTPFSS	DEG_SCF_FBW7_1	112:117	Mutation rewiring degron network	0.0556
p.S127F	ACH-000097	Breast Cancer	CCLE	PTPFSS	DEG_SCF_FBW7_1	112:117	Mutation rewiring degron network	0.0556
p.S127F	ACH-002208	Breast Cancer	CCLE	PTPFSS	DEG_SCF_FBW7_1	112:117	Mutation rewiring degron network	0.0556
p.S127F	YMB-1-E	breast	COSMIC	PTPFSS	DEG_SCF_FBW7_1	112:117	Mutation rewiring degron network	0.0556
p.R118Q	SIDM00433	T-Lymphoblastic Leukemia	GDSC	PTPFSS	DEG_SCF_FBW7_1	112:117	Mutation rewiring degron network	0.3056
p.R118Q	ACH-000795	Leukemia	CCLE	PTPFSS	DEG_SCF_FBW7_1	112:117	Mutation rewiring degron network	0.3056
p.R118Q	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	PTPFSS	DEG_SCF_FBW7_1	112:117	Mutation rewiring degron network	0.3056
p.N1184H	SIDM00643	Non-Cancerous	GDSC	QKENF	DEG_APCC_KENBOX_2	1181:1185	Mutation altering degron motif	0.7423
p.N1184H	ACH-002363	Non-Cancerous	CCLE	QKENF	DEG_APCC_KENBOX_2	1181:1185	Mutation altering degron motif	0.7423
p.S362T	SIDM00122	Breast Carcinoma	GDSC	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation blocking phosphorylation signal	0.7222
p.S362T	SIDM00122	Breast Carcinoma	GDSC	PKRTPLSS	DEG_SCF_FBW7_1	363:370	Mutation blocking phosphorylation signal	0.75
p.S362T	ACH-000288	Breast Cancer	CCLE	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation blocking phosphorylation signal	0.7222
p.S362T	ACH-000288	Breast Cancer	CCLE	PKRTPLSS	DEG_SCF_FBW7_1	363:370	Mutation blocking phosphorylation signal	0.75
p.S362T	BT-549	breast	COSMIC	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation blocking phosphorylation signal	0.7222
p.S362T	BT-549	breast	COSMIC	PKRTPLSS	DEG_SCF_FBW7_1	363:370	Mutation blocking phosphorylation signal	0.75
p.S1236A	SIDM01099	Neuroblastoma	GDSC	VKTTS	DEG_SPOP_SBC_1	1229:1233	Mutation rewiring degron network	0.25
p.S1236A	SIDM00844	Burkitt's Lymphoma	GDSC	VKTTS	DEG_SPOP_SBC_1	1229:1233	Mutation rewiring degron network	0.25
p.S902P	SIDM00879	Breast Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	900:904	Mutation altering degron motif	0.7863
p.S902P	ACH-000349	Breast Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	900:904	Mutation altering degron motif	0.7863
p.S902P	HCC1500	breast	COSMIC	VPSTT	DEG_SPOP_SBC_1	900:904	Mutation altering degron motif	0.7863
p.S376L	SIDM00887	Other Solid Cancers	GDSC	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.2222
p.S376L	SIDM00887	Other Solid Cancers	GDSC	PKRTPLSS	DEG_SCF_FBW7_1	363:370	Mutation rewiring degron network	0.1667
p.S376L	ACH-000211	Brain Cancer	CCLE	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.2222
p.S376L	ACH-000211	Brain Cancer	CCLE	PKRTPLSS	DEG_SCF_FBW7_1	363:370	Mutation rewiring degron network	0.1667
p.S376L	Daoy	central nervous system	COSMIC	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.2222
p.S376L	Daoy	central nervous system	COSMIC	PKRTPLSS	DEG_SCF_FBW7_1	363:370	Mutation rewiring degron network	0.1667
p.V905M	ACH-001369	Ovarian Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.3056
p.R102S	ACH-001412	Bladder Cancer	CCLE	PTPFSS	DEG_SCF_FBW7_1	112:117	Mutation rewiring degron network	0.0556
p.F1235L	ACH-002508	Skin Cancer	CCLE	VKTTS	DEG_SPOP_SBC_1	1229:1233	Mutation rewiring degron network	0.2778
p.S895P	HCC1500	breast	COSMIC	VPSTT	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.1944
p.S355T	BT-549	breast	COSMIC	KRTPLSSII	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.0833
p.S355T	BT-549	breast	COSMIC	PKRTPLSS	DEG_SCF_FBW7_1	363:370	Mutation rewiring degron network	0.1111
p.S120F	YMB-1-E	breast	COSMIC	PTPFSS	DEG_SCF_FBW7_1	112:117	Mutation rewiring degron network	0.25
p.D1798N	HT-115	large intestine	COSMIC	INVHGD	LIG_APCC_ABBA_1	1800:1805	Mutation rewiring degron network	0.2778
p.T1967P	HT-115	large intestine	COSMIC	LNIYED	LIG_APCC_ABBA_1	1956:1961	Mutation rewiring degron network	0.1667
p.R111Q	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	PTPFSS	DEG_SCF_FBW7_1	112:117	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EXPH5

UniProt ID: Q8NEV8

Entrez ID: 23086

Protein name: Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EXPH5 in