DegronMD

Uniprot ID: Q8NEV8

Source protein: Exophilin-5

Source gene: EXPH5

Class: DEG_SPOP_SBC_1

Location: 1229:1233

E3 ligase: SPOP

DEGRON score: 0.8939

ASA_SCORE: 96.32

COIL: 0.8514

CONS_SCORE: 0.9075

DSS_SCORE: 0.3705

HELIX: 0.028

FCONS_SCORE: 1.0511

RIG_SCORE: 0.7697

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1222L	TCGA-22-4595	LUSC	TCGA	VKTTS	DEG_SPOP_SBC_1	0.1389
p.S1236F	TCGA-DK-A3WW	BLCA	TCGA	VKTTS	DEG_SPOP_SBC_1	0.25
p.T1234R	TCGA-DU-6402	LGG	TCGA	VKTTS	DEG_SPOP_SBC_1	0.3056
p.E1219K	DO9002	COAD	ICGC	VKTTS	DEG_SPOP_SBC_1	0.0556
p.P1236S	DO220913	MELA	ICGC	VKTTS	DEG_SPOP_SBC_1	0.25
p.S1237F	DO28014	OV	ICGC	VKTTS	DEG_SPOP_SBC_1	0.2222
p.S1236A	SIDM01099	Neuroblastoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.25
p.S1236A	SIDM00844	Burkitt's Lymphoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.25
p.F1235L	ACH-002508	Skin Cancer	CCLE	VKTTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15075	Serine/threonine-protein kinase DCLK1	DEG_SPOP_SBC_1	154:158	VKTTS	SPOP	0.9667	More...
P19838	Nuclear factor NF-kappa-B p105 subunit	DEG_SPOP_SBC_1	895:899	VKTTS	SPOP	0.9613	More...
Q14151	Scaffold attachment factor B2	DEG_SPOP_SBC_1	585:589	VKTTS	SPOP	0.8543	More...
Q8NEV8	Exophilin-5	DEG_SPOP_SBC_1	1229:1233	VKTTS	SPOP	0.8939	More...
Q5T7N2	LINE-1 type transposase domain-containing protein 1	DEG_SPOP_SBC_1	492:496	VKTTS	SPOP	0.9534	More...
Q8WWW8	GRB2-associated-binding protein 3	DEG_SPOP_SBC_1	88:92	VKTTS	SPOP	0.6909	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons