DegronMD - Q5T7N2(L1TD1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A16V	TCGA-AP-A1DK	UCEC	TCGA	KKENI	DEG_APCC_KENBOX_2	18:22	Mutation rewiring degron network	0.2778
p.A16V	DO42033	UCEC	ICGC	KKENI	DEG_APCC_KENBOX_2	18:22	Mutation rewiring degron network	0.2778
p.R504H	TCGA-CA-5254	COAD	TCGA	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.1111
p.R504H	DO8674	COAD	ICGC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.1111
p.G484E	TCGA-EE-A2A6	SKCM	TCGA	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.1111
p.G484E	DO37591	SKCM	ICGC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.1111
p.K493N	TCGA-EO-A3AY	UCEC	TCGA	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation altering degron motif	0.5806
p.K493N	DO43202	UCEC	ICGC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation altering degron motif	0.5806
p.E20G	TCGA-G4-6588	COAD	TCGA	KKENI	DEG_APCC_KENBOX_2	18:22	Mutation altering degron motif	0.7199
p.E20G	DO10140	COAD	ICGC	KKENI	DEG_APCC_KENBOX_2	18:22	Mutation altering degron motif	0.7199
p.G490R	TCGA-GF-A6C9	SKCM	TCGA	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.2778
p.G490R	DO51254	SKCM	ICGC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.2778
p.R504C	TCGA-L9-A7SV	LUAD	TCGA	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.1111
p.R504C	DO49875	LUAD	ICGC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.1111
p.R504C	SIDM00294	Small Cell Lung Carcinoma	GDSC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.1111
p.R504C	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.1111
p.R504C	SIDM00996	Thyroid Gland Carcinoma	GDSC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.1111
p.R504S	TCGA-MN-A4N1	LUAD	TCGA	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.1111
p.R504S	DO45328	LUAD	ICGC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.1111
p.K500T	DO8898	COAD	ICGC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation substituting flanking lysine	0.3333
p.E20K	DO222875	MELA	ICGC	KKENI	DEG_APCC_KENBOX_2	18:22	Mutation altering degron motif	0.7022
p.E488G	DO222908	MELA	ICGC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.2222
p.E483G	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.0833
p.E483G	SIDM00845	Burkitt's Lymphoma	GDSC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.0833
p.E483G	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.0833
p.E483G	SIDM01099	Neuroblastoma	GDSC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.0833
p.E483G	SIDM00793	Burkitt's Lymphoma	GDSC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.0833
p.E483G	SIDM01133	Other Solid Cancers	GDSC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.0833
p.E483G	SIDM00721	Small Cell Lung Carcinoma	GDSC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.0833
p.E483G	SIDM00808	Burkitt's Lymphoma	GDSC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.0833
p.E483G	SIDM01254	Burkitt's Lymphoma	GDSC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.0833
p.S487C	SIDM00330	Neuroblastoma	GDSC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.1944
p.S487C	ACH-001355	Neuroblastoma	CCLE	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.1944
p.S487C	LAN-6	autonomic ganglia	COSMIC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.1944
p.R27S	SIDM00454	Rhabdomyosarcoma	GDSC	KKENI	DEG_APCC_KENBOX_2	18:22	Mutation rewiring degron network	0.1944
p.R27S	SIDM00200	Ewing's Sarcoma	GDSC	KKENI	DEG_APCC_KENBOX_2	18:22	Mutation rewiring degron network	0.1944
p.R27S	SIDM01112	Osteosarcoma	GDSC	KKENI	DEG_APCC_KENBOX_2	18:22	Mutation rewiring degron network	0.1944
p.R27S	SIDM00493	Other Solid Cancers	GDSC	KKENI	DEG_APCC_KENBOX_2	18:22	Mutation rewiring degron network	0.1944
p.R27S	SIDM01173	Rhabdomyosarcoma	GDSC	KKENI	DEG_APCC_KENBOX_2	18:22	Mutation rewiring degron network	0.1944
p.R27S	SIDM00641	Burkitt's Lymphoma	GDSC	KKENI	DEG_APCC_KENBOX_2	18:22	Mutation rewiring degron network	0.1944
p.K500R	SIDM00656	Burkitt's Lymphoma	GDSC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation substituting flanking lysine	0.3333
p.K500R	SIDM00641	Burkitt's Lymphoma	GDSC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation substituting flanking lysine	0.3333
p.K500R	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation substituting flanking lysine	0.3333
p.E488D	SIDM00844	Burkitt's Lymphoma	GDSC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.2222
p.E488D	ACH-000654	Lymphoma	CCLE	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.2222
p.E488D	Raji	haematopoietic and lymphoid tissue	COSMIC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.2222
p.E488Q	SIDM00225	Melanoma	GDSC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.2222
p.E488Q	ACH-002143	Skin Cancer	CCLE	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.2222
p.E488Q	IST-MEL1	skin	COSMIC	VKTTS	DEG_SPOP_SBC_1	492:496	Mutation rewiring degron network	0.2222
p.Q29L	ACH-000355	Lung Cancer	CCLE	KKENI	DEG_APCC_KENBOX_2	18:22	Mutation rewiring degron network	0.1389
p.R14T	ACH-000617	Ovarian Cancer	CCLE	KKENI	DEG_APCC_KENBOX_2	18:22	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

L1TD1

UniProt ID: Q5T7N2

Entrez ID: 54596

Protein name: LINE-1 type transposase domain-containing protein 1 (ES cell-associated protein 11)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for L1TD1 in