DegronMD

Uniprot ID: Q5T7N2

Source protein: LINE-1 type transposase domain-containing protein 1

Source gene: L1TD1

Class: DEG_SPOP_SBC_1

Location: 492:496

E3 ligase: SPOP

DEGRON score: 0.9534

ASA_SCORE: 79.52

COIL: 0.6206

CONS_SCORE: 0.3887

DSS_SCORE: 0.5674

HELIX: 0.0484

FCONS_SCORE: 1.1179

RIG_SCORE: 0.7178

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R504H	TCGA-CA-5254	COAD	TCGA	VKTTS	DEG_SPOP_SBC_1	0.1111
p.R504H	DO8674	COAD	ICGC	VKTTS	DEG_SPOP_SBC_1	0.1111
p.G484E	TCGA-EE-A2A6	SKCM	TCGA	VKTTS	DEG_SPOP_SBC_1	0.1111
p.G484E	DO37591	SKCM	ICGC	VKTTS	DEG_SPOP_SBC_1	0.1111
p.K493N	TCGA-EO-A3AY	UCEC	TCGA	VKTTS	DEG_SPOP_SBC_1	0.5806
p.K493N	DO43202	UCEC	ICGC	VKTTS	DEG_SPOP_SBC_1	0.5806
p.G490R	TCGA-GF-A6C9	SKCM	TCGA	VKTTS	DEG_SPOP_SBC_1	0.2778
p.G490R	DO51254	SKCM	ICGC	VKTTS	DEG_SPOP_SBC_1	0.2778
p.R504C	TCGA-L9-A7SV	LUAD	TCGA	VKTTS	DEG_SPOP_SBC_1	0.1111
p.R504C	DO49875	LUAD	ICGC	VKTTS	DEG_SPOP_SBC_1	0.1111
p.R504C	SIDM00294	Small Cell Lung Carcinoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.1111
p.R504C	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.1111
p.R504C	SIDM00996	Thyroid Gland Carcinoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.1111
p.R504S	TCGA-MN-A4N1	LUAD	TCGA	VKTTS	DEG_SPOP_SBC_1	0.1111
p.R504S	DO45328	LUAD	ICGC	VKTTS	DEG_SPOP_SBC_1	0.1111
p.K500T	DO8898	COAD	ICGC	VKTTS	DEG_SPOP_SBC_1	0.3333
p.E488G	DO222908	MELA	ICGC	VKTTS	DEG_SPOP_SBC_1	0.2222
p.E483G	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.0833
p.E483G	SIDM00845	Burkitt's Lymphoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.0833
p.E483G	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.0833
p.E483G	SIDM01099	Neuroblastoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.0833
p.E483G	SIDM00793	Burkitt's Lymphoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.0833
p.E483G	SIDM01133	Other Solid Cancers	GDSC	VKTTS	DEG_SPOP_SBC_1	0.0833
p.E483G	SIDM00721	Small Cell Lung Carcinoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.0833
p.E483G	SIDM00808	Burkitt's Lymphoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.0833
p.E483G	SIDM01254	Burkitt's Lymphoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.0833
p.S487C	SIDM00330	Neuroblastoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.1944
p.S487C	ACH-001355	Neuroblastoma	CCLE	VKTTS	DEG_SPOP_SBC_1	0.1944
p.S487C	LAN-6	autonomic_ganglia	COSMIC	VKTTS	DEG_SPOP_SBC_1	0.1944
p.K500R	SIDM00656	Burkitt's Lymphoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.3333
p.K500R	SIDM00641	Burkitt's Lymphoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.3333
p.K500R	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.3333
p.E488D	SIDM00844	Burkitt's Lymphoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.2222
p.E488D	ACH-000654	Lymphoma	CCLE	VKTTS	DEG_SPOP_SBC_1	0.2222
p.E488D	Raji	haematopoietic_and_lymphoid_tissue	COSMIC	VKTTS	DEG_SPOP_SBC_1	0.2222
p.E488Q	SIDM00225	Melanoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.2222
p.E488Q	ACH-002143	Skin Cancer	CCLE	VKTTS	DEG_SPOP_SBC_1	0.2222
p.E488Q	IST-MEL1	skin	COSMIC	VKTTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15075	Serine/threonine-protein kinase DCLK1	DEG_SPOP_SBC_1	154:158	VKTTS	SPOP	0.9667	More...
P19838	Nuclear factor NF-kappa-B p105 subunit	DEG_SPOP_SBC_1	895:899	VKTTS	SPOP	0.9613	More...
Q14151	Scaffold attachment factor B2	DEG_SPOP_SBC_1	585:589	VKTTS	SPOP	0.8543	More...
Q8NEV8	Exophilin-5	DEG_SPOP_SBC_1	1229:1233	VKTTS	SPOP	0.8939	More...
Q5T7N2	LINE-1 type transposase domain-containing protein 1	DEG_SPOP_SBC_1	492:496	VKTTS	SPOP	0.9534	More...
Q8WWW8	GRB2-associated-binding protein 3	DEG_SPOP_SBC_1	88:92	VKTTS	SPOP	0.6909	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VKTTS

Degron related mutations and impact score

Drug responses associated with L1TD1 mutations

All proteins holding degron of VKTTS