DegronMD

Uniprot ID: P19838

Source protein: Nuclear factor NF-kappa-B p105 subunit

Source gene: NFKB1

Class: DEG_SPOP_SBC_1

Location: 895:899

E3 ligase: SPOP

DEGRON score: 0.9613

ASA_SCORE: 99.56

COIL: 0.8954

CONS_SCORE: 0.1558

DSS_SCORE: 0.4659

HELIX: 0.0694

FCONS_SCORE: 0.5854

RIG_SCORE: 0.6592

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S893P	TCGA-19-1388	GBM	TCGA	VKTTS	DEG_SPOP_SBC_1	0.7222
p.S893Y	TCGA-19-1388	GBM	TCGA	VKTTS	DEG_SPOP_SBC_1	0.7222
p.S908L	TCGA-A5-A2K3	UCEC	TCGA	VKTTS	DEG_SPOP_SBC_1	0.0833
p.S908L	TCGA-FS-A1ZZ	SKCM	TCGA	VKTTS	DEG_SPOP_SBC_1	0.0833
p.S904L	TCGA-AG-A002	READ	TCGA	VKTTS	DEG_SPOP_SBC_1	0.1944
p.S893F	TCGA-AO-A0JD	BRCA	TCGA	VKTTS	DEG_SPOP_SBC_1	0.7222
p.P909H	TCGA-AX-A06F	UCEC	TCGA	VKTTS	DEG_SPOP_SBC_1	0.0556
p.A902D	TCGA-UF-A7JO	HNSC	TCGA	VKTTS	DEG_SPOP_SBC_1	0.25
p.Q901E	TCGA-VS-A9UR	CESC	TCGA	VKTTS	DEG_SPOP_SBC_1	0.2778
p.S892F	DO2860	BRCA	ICGC	VKTTS	DEG_SPOP_SBC_1	0.6944
p.Q900E	DO219739	CESC	ICGC	VKTTS	DEG_SPOP_SBC_1	0.3056
p.S892Y	DO13797	GBM	ICGC	VKTTS	DEG_SPOP_SBC_1	0.6944
p.S892P	DO13797	GBM	ICGC	VKTTS	DEG_SPOP_SBC_1	0.6944
p.S892P	DO229245	THCA	ICGC	VKTTS	DEG_SPOP_SBC_1	0.6944
p.A901D	DO219088	HNSC	ICGC	VKTTS	DEG_SPOP_SBC_1	0.2778
p.A891S	DO228952	LICA	ICGC	VKTTS	DEG_SPOP_SBC_1	0.2222
p.P894L	DO220852	MELA	ICGC	VKTTS	DEG_SPOP_SBC_1	0.3056
p.S907L	DO37412	SKCM	ICGC	VKTTS	DEG_SPOP_SBC_1	0.5556
p.S907L	DO43899	UCEC	ICGC	VKTTS	DEG_SPOP_SBC_1	0.5556
p.P908H	DO41752	UCEC	ICGC	VKTTS	DEG_SPOP_SBC_1	0.0833
p.A885G	SIDM01368	Gastric Carcinoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.0556
p.A885G	ACH-000255	Gastric Cancer	CCLE	VKTTS	DEG_SPOP_SBC_1	0.0556
p.S893N	ACH-000999	Colon/Colorectal Cancer	CCLE	VKTTS	DEG_SPOP_SBC_1	0.7222
p.V896M	ACH-001377	Pancreatic Cancer	CCLE	VKTTS	DEG_SPOP_SBC_1	0.7208

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15075	Serine/threonine-protein kinase DCLK1	DEG_SPOP_SBC_1	154:158	VKTTS	SPOP	0.9667	More...
P19838	Nuclear factor NF-kappa-B p105 subunit	DEG_SPOP_SBC_1	895:899	VKTTS	SPOP	0.9613	More...
Q14151	Scaffold attachment factor B2	DEG_SPOP_SBC_1	585:589	VKTTS	SPOP	0.8543	More...
Q8NEV8	Exophilin-5	DEG_SPOP_SBC_1	1229:1233	VKTTS	SPOP	0.8939	More...
Q5T7N2	LINE-1 type transposase domain-containing protein 1	DEG_SPOP_SBC_1	492:496	VKTTS	SPOP	0.9534	More...
Q8WWW8	GRB2-associated-binding protein 3	DEG_SPOP_SBC_1	88:92	VKTTS	SPOP	0.6909	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons