DegronMD

Uniprot ID: Q14151

Source protein: Scaffold attachment factor B2

Source gene: SAFB2

Class: DEG_SPOP_SBC_1

Location: 585:589

E3 ligase: SPOP

DEGRON score: 0.8543

ASA_SCORE: 96.26

COIL: 0.8892

CONS_SCORE: 0.355

DSS_SCORE: 0.6533

HELIX: 0.0524

FCONS_SCORE: 0.87

RIG_SCORE: 0.6994

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S596F	TCGA-GN-A266	SKCM	TCGA	VKTTS	DEG_SPOP_SBC_1	0.1389
p.S596F	DO37432	SKCM	ICGC	VKTTS	DEG_SPOP_SBC_1	0.1389
p.S595R	DO229006	LICA	ICGC	VKTTS	DEG_SPOP_SBC_1	0.1667
p.S591F	DO229224	THCA	ICGC	VKTTS	DEG_SPOP_SBC_1	0.7222
p.R590K	SIDM00259	Neuroblastoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.3056
p.R590K	ACH-002278	Neuroblastoma	CCLE	VKTTS	DEG_SPOP_SBC_1	0.3056
p.R590K	NB10	autonomic_ganglia	COSMIC	VKTTS	DEG_SPOP_SBC_1	0.3056
p.S577L	SIDM00217	Colorectal Carcinoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.1111
p.S577L	ACH-000999	Colon/Colorectal Cancer	CCLE	VKTTS	DEG_SPOP_SBC_1	0.1111
p.S577L	SNU-1040	large_intestine	COSMIC	VKTTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15075	Serine/threonine-protein kinase DCLK1	DEG_SPOP_SBC_1	154:158	VKTTS	SPOP	0.9667	More...
P19838	Nuclear factor NF-kappa-B p105 subunit	DEG_SPOP_SBC_1	895:899	VKTTS	SPOP	0.9613	More...
Q14151	Scaffold attachment factor B2	DEG_SPOP_SBC_1	585:589	VKTTS	SPOP	0.8543	More...
Q8NEV8	Exophilin-5	DEG_SPOP_SBC_1	1229:1233	VKTTS	SPOP	0.8939	More...
Q5T7N2	LINE-1 type transposase domain-containing protein 1	DEG_SPOP_SBC_1	492:496	VKTTS	SPOP	0.9534	More...
Q8WWW8	GRB2-associated-binding protein 3	DEG_SPOP_SBC_1	88:92	VKTTS	SPOP	0.6909	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons