DegronMD

Uniprot ID: O15075

Source protein: Serine/threonine-protein kinase DCLK1

Source gene: DCLK1

Class: DEG_SPOP_SBC_1

Location: 154:158

E3 ligase: SPOP

DEGRON score: 0.9667

ASA_SCORE: 83.92

COIL: 0.8614

CONS_SCORE: 0.428

DSS_SCORE: 0.3678

HELIX: 0.094

FCONS_SCORE: 0.9916

RIG_SCORE: 0.7912

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A167T	TCGA-17-Z054	LUAD	TCGA	VKTTS	DEG_SPOP_SBC_1	0.0833
p.K144R	TCGA-46-6026	LUSC	TCGA	VKTTS	DEG_SPOP_SBC_1	0.1667
p.K144R	TCGA-CG-4466	STAD	TCGA	VKTTS	DEG_SPOP_SBC_1	0.1667
p.K144R	DO233708	GACA	ICGC	VKTTS	DEG_SPOP_SBC_1	0.1667
p.K144R	DO26740	LUSC	ICGC	VKTTS	DEG_SPOP_SBC_1	0.1667
p.K144R	DO38695	STAD	ICGC	VKTTS	DEG_SPOP_SBC_1	0.1667
p.K144N	TCGA-AX-A05Z	UCEC	TCGA	VKTTS	DEG_SPOP_SBC_1	0.1667
p.K144N	DO40884	UCEC	ICGC	VKTTS	DEG_SPOP_SBC_1	0.1667
p.R161W	TCGA-BR-8678	STAD	TCGA	VKTTS	DEG_SPOP_SBC_1	0.25
p.R161W	DO47957	STAD	ICGC	VKTTS	DEG_SPOP_SBC_1	0.25
p.N149K	TCGA-CG-4304	STAD	TCGA	VKTTS	DEG_SPOP_SBC_1	0.1944
p.N149K	DO38615	STAD	ICGC	VKTTS	DEG_SPOP_SBC_1	0.1944
p.R161Q	TCGA-HT-7684	LGG	TCGA	VKTTS	DEG_SPOP_SBC_1	0.25
p.R161Q	DO22121	LGG	ICGC	VKTTS	DEG_SPOP_SBC_1	0.25
p.S158W	TCGA-IN-A6RO	STAD	TCGA	VKTTS	DEG_SPOP_SBC_1	0.7874
p.S158W	DO51740	STAD	ICGC	VKTTS	DEG_SPOP_SBC_1	0.7874
p.S158W	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.7874
p.S158W	ACH-002253	Lymphoma	CCLE	VKTTS	DEG_SPOP_SBC_1	0.7874
p.S158W	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	VKTTS	DEG_SPOP_SBC_1	0.7874
p.K144T	DO233214	GACA	ICGC	VKTTS	DEG_SPOP_SBC_1	0.1667
p.S158L	DO222521	MELA	ICGC	VKTTS	DEG_SPOP_SBC_1	0.7667
p.A162V	SIDM00216	Colorectal Carcinoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.2222
p.A162V	ACH-000989	Colon/Colorectal Cancer	CCLE	VKTTS	DEG_SPOP_SBC_1	0.2222
p.A162V	SNU-175	large_intestine	COSMIC	VKTTS	DEG_SPOP_SBC_1	0.2222
p.S165T	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.1389
p.S165T	ACH-002263	Esophageal Cancer	CCLE	VKTTS	DEG_SPOP_SBC_1	0.1389
p.S165T	KYSE-220	oesophagus	COSMIC	VKTTS	DEG_SPOP_SBC_1	0.1389
p.A167V	SIDM01609	Endometrial Carcinoma	GDSC	VKTTS	DEG_SPOP_SBC_1	0.0833
p.V154I	ACH-000966	Ovarian Cancer	CCLE	VKTTS	DEG_SPOP_SBC_1	0.7076
p.V154I	ACH-001063	Ovarian Cancer	CCLE	VKTTS	DEG_SPOP_SBC_1	0.7076
p.N153S	ACH-001664	Gastric Cancer	CCLE	VKTTS	DEG_SPOP_SBC_1	0.3056
p.F167V	SNU-81	large_intestine	COSMIC	VKTTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15075	Serine/threonine-protein kinase DCLK1	DEG_SPOP_SBC_1	154:158	VKTTS	SPOP	0.9667	More...
P19838	Nuclear factor NF-kappa-B p105 subunit	DEG_SPOP_SBC_1	895:899	VKTTS	SPOP	0.9613	More...
Q14151	Scaffold attachment factor B2	DEG_SPOP_SBC_1	585:589	VKTTS	SPOP	0.8543	More...
Q8NEV8	Exophilin-5	DEG_SPOP_SBC_1	1229:1233	VKTTS	SPOP	0.8939	More...
Q5T7N2	LINE-1 type transposase domain-containing protein 1	DEG_SPOP_SBC_1	492:496	VKTTS	SPOP	0.9534	More...
Q8WWW8	GRB2-associated-binding protein 3	DEG_SPOP_SBC_1	88:92	VKTTS	SPOP	0.6909	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VKTTS

Degron related mutations and impact score

Drug responses associated with DCLK1 mutations

All proteins holding degron of VKTTS