DegronMD - Q8WWW8(GAB3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S332R	TCGA-61-2095	OV	TCGA	RRISLSGLD	DEG_APCC_DBOX_1	341:349	Mutation substituting flanking lysine	0.1944
p.S145N	TCGA-AP-A1DK	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.1667
p.V85M	TCGA-AZ-6601	COAD	TCGA	VKTTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.25
p.V85M	DO8119	COAD	ICGC	VKTTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.25
p.R343I	TCGA-BS-A0TC	UCEC	TCGA	RRISLSGLD	DEG_APCC_DBOX_1	341:349	Mutation altering degron motif	0.8102
p.E79K	TCGA-D3-A8GI	SKCM	TCGA	VKTTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.0833
p.E79K	DO229462	SKCA	ICGC	VKTTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.0833
p.E79K	DO50284	SKCM	ICGC	VKTTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.0833
p.S156Y	TCGA-DU-6392	LGG	TCGA	AASSS	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.3056
p.E79Q	TCGA-FJ-A3ZF	BLCA	TCGA	VKTTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.0833
p.E79Q	DO500	BLCA	ICGC	VKTTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.0833
p.A153D	TCGA-VQ-A91K	STAD	TCGA	AASSS	DEG_SPOP_SBC_1	151:155	Mutation altering degron motif	0.7793
p.I343M	DO1221	BRCA	ICGC	RRISLSGLD	DEG_APCC_DBOX_1	341:349	Mutation altering degron motif	0.6507
p.S144N	DO233108	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.1389
p.S144N	DO42033	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.1389
p.S155Y	DO22237	LGG	ICGC	AASSS	DEG_SPOP_SBC_1	151:155	Mutation altering degron motif	0.712
p.L348S	DO228931	LICA	ICGC	RRISLSGLD	DEG_APCC_DBOX_1	341:349	Mutation altering degron motif	0.7667
p.R93S	DO229019	LICA	ICGC	VKTTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.3056
p.S141Y	DO229025	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.0556
p.A151D	DO229009	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	151:155	Mutation altering degron motif	0.7793
p.R93C	DO50749	LICA	ICGC	VKTTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.3056
p.A149T	DO50760	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.2778
p.T148I	DO222696	MELA	ICGC	AASSS	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.25
p.S331R	DO27987	OV	ICGC	RRISLSGLD	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.0556
p.A152D	DO51785	STAD	ICGC	AASSS	DEG_SPOP_SBC_1	151:155	Mutation altering degron motif	0.6682
p.A165V	DO41542	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.0556
p.R342I	DO42400	UCEC	ICGC	RRISLSGLD	DEG_APCC_DBOX_1	341:349	Mutation altering degron motif	0.8102
p.F95S	ACH-001991	Primary	CCLE	VKTTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GAB3

UniProt ID: Q8WWW8

Entrez ID: 139716

Protein name: GRB2-associated-binding protein 3 (GRB2-associated binder 3) (Growth factor receptor bound protein 2-associated protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GAB3 in