DegronMD

Uniprot ID: Q8WWW8

Source protein: GRB2-associated-binding protein 3

Source gene: GAB3

Class: DEG_APCC_DBOX_1

Location: 341:349

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9899

ASA_SCORE: 72.1889

COIL: 0.7339

CONS_SCORE: 0.342

DSS_SCORE: 0.3972

HELIX: 0.1258

FCONS_SCORE: 1.0267

RIG_SCORE: 0.7409

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R343I	TCGA-BS-A0TC	UCEC	TCGA	RRISLSGLD	DEG_APCC_DBOX_1	0.8102
p.R342I	DO42400	UCEC	ICGC	RRISLSGLD	DEG_APCC_DBOX_1	0.8102
p.L348S	DO228931	LICA	ICGC	RRISLSGLD	DEG_APCC_DBOX_1	0.7667
p.I343M	DO1221	BRCA	ICGC	RRISLSGLD	DEG_APCC_DBOX_1	0.6507
p.S332R	TCGA-61-2095	OV	TCGA	RRISLSGLD	DEG_APCC_DBOX_1	0.1944
p.S331R	DO27987	OV	ICGC	RRISLSGLD	DEG_APCC_DBOX_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWW8	GRB2-associated-binding protein 3	DEG_APCC_DBOX_1	341:349	RRISLSGLD	APC,CDC20,FZR1	0.9899	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons