DegronMD

Uniprot ID: Q8WWW8

Source protein: GRB2-associated-binding protein 3

Source gene: GAB3

Class: DEG_SPOP_SBC_1

Location: 88:92

E3 ligase: SPOP

DEGRON score: 0.6909

ASA_SCORE: 53.82

COIL: 0.4936

CONS_SCORE: 0.5778

DSS_SCORE: 0.0215

HELIX: 0.0062

FCONS_SCORE: 1.1664

RIG_SCORE: 0.9513

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V85M	TCGA-AZ-6601	COAD	TCGA	VKTTS	DEG_SPOP_SBC_1	0.25
p.V85M	DO8119	COAD	ICGC	VKTTS	DEG_SPOP_SBC_1	0.25
p.E79K	TCGA-D3-A8GI	SKCM	TCGA	VKTTS	DEG_SPOP_SBC_1	0.0833
p.E79K	DO229462	SKCA	ICGC	VKTTS	DEG_SPOP_SBC_1	0.0833
p.E79K	DO50284	SKCM	ICGC	VKTTS	DEG_SPOP_SBC_1	0.0833
p.E79Q	TCGA-FJ-A3ZF	BLCA	TCGA	VKTTS	DEG_SPOP_SBC_1	0.0833
p.E79Q	DO500	BLCA	ICGC	VKTTS	DEG_SPOP_SBC_1	0.0833
p.R93S	DO229019	LICA	ICGC	VKTTS	DEG_SPOP_SBC_1	0.3056
p.R93C	DO50749	LICA	ICGC	VKTTS	DEG_SPOP_SBC_1	0.3056
p.F95S	ACH-001991	Primary	CCLE	VKTTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15075	Serine/threonine-protein kinase DCLK1	DEG_SPOP_SBC_1	154:158	VKTTS	SPOP	0.9667	More...
P19838	Nuclear factor NF-kappa-B p105 subunit	DEG_SPOP_SBC_1	895:899	VKTTS	SPOP	0.9613	More...
Q14151	Scaffold attachment factor B2	DEG_SPOP_SBC_1	585:589	VKTTS	SPOP	0.8543	More...
Q8NEV8	Exophilin-5	DEG_SPOP_SBC_1	1229:1233	VKTTS	SPOP	0.8939	More...
Q5T7N2	LINE-1 type transposase domain-containing protein 1	DEG_SPOP_SBC_1	492:496	VKTTS	SPOP	0.9534	More...
Q8WWW8	GRB2-associated-binding protein 3	DEG_SPOP_SBC_1	88:92	VKTTS	SPOP	0.6909	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons