DegronMD - O15075(DCLK1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A167T	TCGA-17-Z054	LUAD	TCGA	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.0833
p.K144R	TCGA-46-6026	LUSC	TCGA	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation substituting flanking lysine	0.1667
p.K144R	TCGA-CG-4466	STAD	TCGA	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation substituting flanking lysine	0.1667
p.K144R	DO233708	GACA	ICGC	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation substituting flanking lysine	0.1667
p.K144R	DO26740	LUSC	ICGC	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation substituting flanking lysine	0.1667
p.K144R	DO38695	STAD	ICGC	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation substituting flanking lysine	0.1667
p.P308T	TCGA-49-AAR0	LUAD	TCGA	PASTS	DEG_SPOP_SBC_1	308:312	Mutation altering degron motif	0.7031
p.P308T	DO218917	LUAD	ICGC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation altering degron motif	0.7031
p.T311I	TCGA-A5-A1OF	UCEC	TCGA	PASTS	DEG_SPOP_SBC_1	308:312	Mutation altering degron motif	0.7078
p.T311I	DO42568	UCEC	ICGC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation altering degron motif	0.7078
p.K144N	TCGA-AX-A05Z	UCEC	TCGA	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation substituting flanking lysine	0.1667
p.K144N	DO40884	UCEC	ICGC	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation substituting flanking lysine	0.1667
p.K306R	TCGA-BR-6709	STAD	TCGA	PASTS	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.2778
p.K306R	DO38356	STAD	ICGC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.2778
p.R161W	TCGA-BR-8678	STAD	TCGA	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.25
p.R161W	DO47957	STAD	ICGC	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.25
p.N149K	TCGA-CG-4304	STAD	TCGA	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.1944
p.N149K	DO38615	STAD	ICGC	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.1944
p.S302Y	TCGA-D7-6815	STAD	TCGA	PASTS	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.1667
p.S302Y	DO38603	STAD	ICGC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.1667
p.S310F	TCGA-DC-5869	READ	TCGA	PASTS	DEG_SPOP_SBC_1	308:312	Mutation altering degron motif	0.7982
p.S310F	DO36584	READ	ICGC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation altering degron motif	0.7982
p.G300R	TCGA-DM-A1D7	COAD	TCGA	PASTS	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.1111
p.G300R	DO10044	COAD	ICGC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.1111
p.R304C	TCGA-DM-A1DA	COAD	TCGA	PASTS	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.2222
p.R304C	DO7852	COAD	ICGC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.2222
p.R304C	DO232761	PBCA	ICGC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.2222
p.P318T	TCGA-EE-A181	SKCM	TCGA	PASTS	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.1667
p.P318T	DO37444	SKCM	ICGC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.1667
p.S305G	TCGA-EW-A1IZ	BRCA	TCGA	PASTS	DEG_SPOP_SBC_1	308:312	Mutation blocking phosphorylation signal	0.6944
p.S305G	DO2937	BRCA	ICGC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation blocking phosphorylation signal	0.6944
p.R161Q	TCGA-HT-7684	LGG	TCGA	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.25
p.R161Q	DO22121	LGG	ICGC	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.25
p.S158W	TCGA-IN-A6RO	STAD	TCGA	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.7874
p.S158W	DO51740	STAD	ICGC	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.7874
p.S158W	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.7874
p.S158W	ACH-002253	Lymphoma	CCLE	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.7874
p.S158W	JSC-1	haematopoietic and lymphoid tissue	COSMIC	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.7874
p.P308R	TCGA-IN-A6RS	STAD	TCGA	PASTS	DEG_SPOP_SBC_1	308:312	Mutation altering degron motif	0.7512
p.P308R	DO51743	STAD	ICGC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation altering degron motif	0.7512
p.A309D	TCGA-IW-A3M5	SARC	TCGA	PASTS	DEG_SPOP_SBC_1	308:312	Mutation altering degron motif	0.6682
p.A309D	DO220176	SARC	ICGC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation altering degron motif	0.6682
p.K306T	TCGA-RD-A7BT	STAD	TCGA	PASTS	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.2778
p.K306T	DO50131	STAD	ICGC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.2778
p.K144T	DO233214	GACA	ICGC	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation substituting flanking lysine	0.1667
p.P301S	DO233652	GACA	ICGC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.1389
p.R304H	DO233767	GACA	ICGC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.2222
p.R304H	DO49150	PACA	ICGC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.2222
p.R304H	DO49466	PACA	ICGC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.2222
p.S305R	DO229028	LICA	ICGC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation blocking phosphorylation signal	0.6944
p.P301T	DO229025	LICA	ICGC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.1389
p.S307F	DO231774	LINC	ICGC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation blocking phosphorylation signal	0.75
p.S158L	DO222521	MELA	ICGC	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.7667
p.Q321H	DO27881	ORCA	ICGC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.0833
p.Q321H	SIDM00217	Colorectal Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.0833
p.Q321H	ACH-000999	Colon/Colorectal Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.0833
p.Q321H	SNU-1040	large intestine	COSMIC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.0833
p.P301L	DO49172	PACA	ICGC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.1389
p.S307Y	DO229446	SKCA	ICGC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation blocking phosphorylation signal	0.75
p.A162V	SIDM00216	Colorectal Carcinoma	GDSC	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.2222
p.A162V	ACH-000989	Colon/Colorectal Cancer	CCLE	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.2222
p.A162V	SNU-175	large intestine	COSMIC	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.2222
p.S165T	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.1389
p.S165T	ACH-002263	Esophageal Cancer	CCLE	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.1389
p.S165T	KYSE-220	oesophagus	COSMIC	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.1389
p.A167V	SIDM01609	Endometrial Carcinoma	GDSC	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.0833
p.V154I	ACH-000966	Ovarian Cancer	CCLE	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.7076
p.V154I	ACH-001063	Ovarian Cancer	CCLE	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.7076
p.N153S	ACH-001664	Gastric Cancer	CCLE	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.3056
p.Q298K	SISO	cervix	COSMIC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation blocking phosphorylation signal	0.5
p.P302T	NCI-H2030	lung	COSMIC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.1667
p.F167V	SNU-81	large intestine	COSMIC	VKTTS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.0833
p.A313E	LS-123	large intestine	COSMIC	PASTS	DEG_SPOP_SBC_1	308:312	Mutation blocking phosphorylation signal	0.75

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DCLK1

UniProt ID: O15075

Entrez ID: 9201

Protein name: Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DCLK1 in