DegronMD

Uniprot ID: O15075

Source protein: Serine/threonine-protein kinase DCLK1

Source gene: DCLK1

Class: DEG_SPOP_SBC_1

Location: 308:312

E3 ligase: SPOP

DEGRON score: 0.9913

ASA_SCORE: 74.32

COIL: 0.888

CONS_SCORE: 0.4185

DSS_SCORE: 0.7924

HELIX: 0.0502

FCONS_SCORE: 1.0001

RIG_SCORE: 0.508

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P308T	TCGA-49-AAR0	LUAD	TCGA	PASTS	DEG_SPOP_SBC_1	0.7031
p.P308T	DO218917	LUAD	ICGC	PASTS	DEG_SPOP_SBC_1	0.7031
p.T311I	TCGA-A5-A1OF	UCEC	TCGA	PASTS	DEG_SPOP_SBC_1	0.7078
p.T311I	DO42568	UCEC	ICGC	PASTS	DEG_SPOP_SBC_1	0.7078
p.K306R	TCGA-BR-6709	STAD	TCGA	PASTS	DEG_SPOP_SBC_1	0.2778
p.K306R	DO38356	STAD	ICGC	PASTS	DEG_SPOP_SBC_1	0.2778
p.S302Y	TCGA-D7-6815	STAD	TCGA	PASTS	DEG_SPOP_SBC_1	0.1667
p.S302Y	DO38603	STAD	ICGC	PASTS	DEG_SPOP_SBC_1	0.1667
p.S310F	TCGA-DC-5869	READ	TCGA	PASTS	DEG_SPOP_SBC_1	0.7982
p.S310F	DO36584	READ	ICGC	PASTS	DEG_SPOP_SBC_1	0.7982
p.G300R	TCGA-DM-A1D7	COAD	TCGA	PASTS	DEG_SPOP_SBC_1	0.1111
p.G300R	DO10044	COAD	ICGC	PASTS	DEG_SPOP_SBC_1	0.1111
p.R304C	TCGA-DM-A1DA	COAD	TCGA	PASTS	DEG_SPOP_SBC_1	0.2222
p.R304C	DO7852	COAD	ICGC	PASTS	DEG_SPOP_SBC_1	0.2222
p.R304C	DO232761	PBCA	ICGC	PASTS	DEG_SPOP_SBC_1	0.2222
p.P318T	TCGA-EE-A181	SKCM	TCGA	PASTS	DEG_SPOP_SBC_1	0.1667
p.P318T	DO37444	SKCM	ICGC	PASTS	DEG_SPOP_SBC_1	0.1667
p.S305G	TCGA-EW-A1IZ	BRCA	TCGA	PASTS	DEG_SPOP_SBC_1	0.6944
p.S305G	DO2937	BRCA	ICGC	PASTS	DEG_SPOP_SBC_1	0.6944
p.P308R	TCGA-IN-A6RS	STAD	TCGA	PASTS	DEG_SPOP_SBC_1	0.7512
p.P308R	DO51743	STAD	ICGC	PASTS	DEG_SPOP_SBC_1	0.7512
p.A309D	TCGA-IW-A3M5	SARC	TCGA	PASTS	DEG_SPOP_SBC_1	0.6682
p.A309D	DO220176	SARC	ICGC	PASTS	DEG_SPOP_SBC_1	0.6682
p.K306T	TCGA-RD-A7BT	STAD	TCGA	PASTS	DEG_SPOP_SBC_1	0.2778
p.K306T	DO50131	STAD	ICGC	PASTS	DEG_SPOP_SBC_1	0.2778
p.P301S	DO233652	GACA	ICGC	PASTS	DEG_SPOP_SBC_1	0.1389
p.R304H	DO233767	GACA	ICGC	PASTS	DEG_SPOP_SBC_1	0.2222
p.R304H	DO49150	PACA	ICGC	PASTS	DEG_SPOP_SBC_1	0.2222
p.R304H	DO49466	PACA	ICGC	PASTS	DEG_SPOP_SBC_1	0.2222
p.S305R	DO229028	LICA	ICGC	PASTS	DEG_SPOP_SBC_1	0.6944
p.P301T	DO229025	LICA	ICGC	PASTS	DEG_SPOP_SBC_1	0.1389
p.S307F	DO231774	LINC	ICGC	PASTS	DEG_SPOP_SBC_1	0.75
p.Q321H	DO27881	ORCA	ICGC	PASTS	DEG_SPOP_SBC_1	0.0833
p.Q321H	SIDM00217	Colorectal Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	0.0833
p.Q321H	ACH-000999	Colon/Colorectal Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	0.0833
p.Q321H	SNU-1040	large_intestine	COSMIC	PASTS	DEG_SPOP_SBC_1	0.0833
p.P301L	DO49172	PACA	ICGC	PASTS	DEG_SPOP_SBC_1	0.1389
p.S307Y	DO229446	SKCA	ICGC	PASTS	DEG_SPOP_SBC_1	0.75
p.Q298K	SISO	cervix	COSMIC	PASTS	DEG_SPOP_SBC_1	0.5
p.P302T	NCI-H2030	lung	COSMIC	PASTS	DEG_SPOP_SBC_1	0.1667
p.A313E	LS-123	large_intestine	COSMIC	PASTS	DEG_SPOP_SBC_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15075	Serine/threonine-protein kinase DCLK1	DEG_SPOP_SBC_1	308:312	PASTS	SPOP	0.9913	More...
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	993:997	PASTS	SPOP	0.8792	More...
O75592	E3 ubiquitin-protein ligase MYCBP2	DEG_SPOP_SBC_1	2725:2729	PASTS	SPOP	0.999	More...
O75694	Nuclear pore complex protein Nup155	DEG_SPOP_SBC_1	11:15	PASTS	SPOP	0.9977	More...
O94973	AP-2 complex subunit alpha-2	DEG_SPOP_SBC_1	646:650	PASTS	SPOP	0.827	More...
O95208	Epsin-2	DEG_SPOP_SBC_1	372:376	PASTS	SPOP	0.9841	More...
P15822	Zinc finger protein 40	DEG_SPOP_SBC_1	2657:2661	PASTS	SPOP	0.9979	More...
P20749	B-cell lymphoma 3 protein	DEG_SPOP_SBC_1	365:369	PASTS	SPOP	0.954	More...
P28908	Tumor necrosis factor receptor superfamily member 8	DEG_SPOP_SBC_1	345:349	PASTS	SPOP	0.9474	More...
Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	DEG_SPOP_SBC_1	927:931	PASTS	SPOP	0.985	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	556:560	PASTS	SPOP	0.7232	More...
Q15788	Nuclear receptor coactivator 1	DEG_SPOP_SBC_1	1181:1185	PASTS	SPOP	0.9984	More...
Q16621	Transcription factor NF-E2 45 kDa subunit	DEG_SPOP_SBC_1	86:90	PASTS	SPOP	0.9466	More...
Q3SXY7	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3	DEG_SPOP_SBC_1	463:467	PASTS	SPOP	0.9585	More...
Q5TCY1	Tau-tubulin kinase 1	DEG_SPOP_SBC_1	1236:1240	PASTS	SPOP	0.9958	More...
Q659A1	Little elongation complex subunit 2	DEG_SPOP_SBC_1	419:423	PASTS	SPOP	0.9906	More...
Q6ZT12	E3 ubiquitin-protein ligase UBR3	DEG_SPOP_SBC_1	1016:1020	PASTS	SPOP	0.5066	More...
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	DEG_SPOP_SBC_1	2005:2009	PASTS	SPOP	0.9657	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	549:553	PASTS	SPOP	0.7898	More...
Q99469	SH3 and cysteine-rich domain-containing protein	DEG_SPOP_SBC_1	28:32	PASTS	SPOP	0.9799	More...
Q99743	Neuronal PAS domain-containing protein 2	DEG_SPOP_SBC_1	650:654	PASTS	SPOP	0.9948	More...
Q9NWS9	Zinc finger protein 446	DEG_SPOP_SBC_1	198:202	PASTS	SPOP	0.9975	More...
Q9UGN4	CMRF35-like molecule 8	DEG_SPOP_SBC_1	126:130	PASTS	SPOP	0.8075	More...
Q9UIU6	Homeobox protein SIX4	DEG_SPOP_SBC_1	356:360	PASTS	SPOP	0.6906	More...
Q9ULD8	Potassium voltage-gated channel subfamily H member 3	DEG_SPOP_SBC_1	928:932	PASTS	SPOP	0.9499	More...
Q9Y4C1	Lysine-specific demethylase 3A	DEG_SPOP_SBC_1	815:819	PASTS	SPOP	0.9164	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	1763:1767	PASTS	SPOP	0.9781	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	1778:1782	PASTS	SPOP	0.9401	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	1820:1824	PASTS	SPOP	0.8745	More...
Q9Y5Y7	Lymphatic vessel endothelial hyaluronic acid receptor 1	DEG_SPOP_SBC_1	188:192	PASTS	SPOP	0.5868	More...
Q6IEE8	Schlafen family member 12-like	DEG_SPOP_SBC_1	372:376	PASTS	SPOP	0.7893	More...
Q6NSJ2	Pleckstrin homology-like domain family B member 3	DEG_SPOP_SBC_1	85:89	PASTS	SPOP	0.9511	More...
Q6ZRI6	Uncharacterized protein C15orf39	DEG_SPOP_SBC_1	753:757	PASTS	SPOP	0.9882	More...
Q8N4U5	T-complex protein 11-like protein 2	DEG_SPOP_SBC_1	51:55	PASTS	SPOP	0.9613	More...
A6NNA2	Serine/arginine repetitive matrix protein 3	DEG_SPOP_SBC_1	467:471	PASTS	SPOP	0.9948	More...
A8MTJ6	Forkhead box protein I3	DEG_SPOP_SBC_1	387:391	PASTS	SPOP	0.9013	More...
Q0P670	Uncharacterized protein SPEM2	DEG_SPOP_SBC_1	482:486	PASTS	SPOP	0.9926	More...
Q8NCL8	Transmembrane protein 116	DEG_SPOP_SBC_1	238:242	PASTS	SPOP	0.963	More...
Q8WTZ4	Putative inactive carbonic anhydrase 5B-like protein	DEG_SPOP_SBC_1	5:9	PASTS	SPOP	0.7966	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PASTS

Degron related mutations and impact score

Drug responses associated with DCLK1 mutations

All proteins holding degron of PASTS