DegronMD - Q6ZT12(UBR3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1062C	TCGA-AN-A046	BRCA	TCGA	PKTSS	DEG_SPOP_SBC_1	1063:1067	Mutation rewiring degron network	0.3056
p.R1062C	DO1285	BRCA	ICGC	PKTSS	DEG_SPOP_SBC_1	1063:1067	Mutation rewiring degron network	0.3056
p.S1026Y	TCGA-D1-A16Y	UCEC	TCGA	PASTS	DEG_SPOP_SBC_1	1016:1020	Mutation rewiring degron network	0.1667
p.S1026Y	TCGA-EO-A22X	UCEC	TCGA	PASTS	DEG_SPOP_SBC_1	1016:1020	Mutation rewiring degron network	0.1667
p.S1026Y	DO43907	UCEC	ICGC	PASTS	DEG_SPOP_SBC_1	1016:1020	Mutation rewiring degron network	0.1667
p.S1026Y	DO41524	UCEC	ICGC	PASTS	DEG_SPOP_SBC_1	1016:1020	Mutation rewiring degron network	0.1667
p.R1062G	TCGA-D1-A17D	UCEC	TCGA	PKTSS	DEG_SPOP_SBC_1	1063:1067	Mutation rewiring degron network	0.3056
p.R1062G	DO41746	UCEC	ICGC	PKTSS	DEG_SPOP_SBC_1	1063:1067	Mutation rewiring degron network	0.3056
p.T1019S	DO225318	BRCA	ICGC	PASTS	DEG_SPOP_SBC_1	1016:1020	Mutation altering degron motif	0.6005
p.P1072S	DO50454	ESAD	ICGC	PKTSS	DEG_SPOP_SBC_1	1063:1067	Mutation rewiring degron network	0.1944
p.R1062H	DO233882	GACA	ICGC	PKTSS	DEG_SPOP_SBC_1	1063:1067	Mutation rewiring degron network	0.3056
p.R1062H	DO46374	OV	ICGC	PKTSS	DEG_SPOP_SBC_1	1063:1067	Mutation rewiring degron network	0.3056
p.A1057S	DO228986	LICA	ICGC	PKTSS	DEG_SPOP_SBC_1	1063:1067	Mutation rewiring degron network	0.1667
p.A1008S	DO229028	LICA	ICGC	PASTS	DEG_SPOP_SBC_1	1016:1020	Mutation rewiring degron network	0.1111
p.P1063T	DO227520	ORCA	ICGC	PKTSS	DEG_SPOP_SBC_1	1063:1067	Mutation altering degron motif	0.7031
p.S1067N	SIDM01137	Pancreatic Carcinoma	GDSC	PKTSS	DEG_SPOP_SBC_1	1063:1067	Mutation altering degron motif	0.7069
p.S1067N	ACH-000235	Pancreatic Cancer	CCLE	PKTSS	DEG_SPOP_SBC_1	1063:1067	Mutation altering degron motif	0.7069
p.S1067N	PANC-04-03	pancreas	COSMIC	PKTSS	DEG_SPOP_SBC_1	1063:1067	Mutation altering degron motif	0.7069
p.A1057T	ACH-000972	Endometrial/Uterine Cancer	CCLE	PKTSS	DEG_SPOP_SBC_1	1063:1067	Mutation rewiring degron network	0.1667

Kaplan plot for UBR3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UBR3

UniProt ID: Q6ZT12

Entrez ID: 130507

Protein name: E3 ubiquitin-protein ligase UBR3 (EC 2.3.2.27) (N-recognin-3) (RING-type E3 ubiquitin transferase UBR3) (Ubiquitin-protein ligase E3-alpha-3) (Ubiquitin-protein ligase E3-alpha-III) (Zinc finger protein 650)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UBR3 in