DegronMD

Uniprot ID: Q6ZT12

Source protein: E3 ubiquitin-protein ligase UBR3

Source gene: UBR3

Class: DEG_SPOP_SBC_1

Location: 1063:1067

E3 ligase: SPOP

DEGRON score: 0.955

ASA_SCORE: 80.16

COIL: 0.8258

CONS_SCORE: 0.2524

DSS_SCORE: 0.5202

HELIX: 0.1026

FCONS_SCORE: 1.0364

RIG_SCORE: 0.6706

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1062C	TCGA-AN-A046	BRCA	TCGA	PKTSS	DEG_SPOP_SBC_1	0.3056
p.R1062C	DO1285	BRCA	ICGC	PKTSS	DEG_SPOP_SBC_1	0.3056
p.R1062G	TCGA-D1-A17D	UCEC	TCGA	PKTSS	DEG_SPOP_SBC_1	0.3056
p.R1062G	DO41746	UCEC	ICGC	PKTSS	DEG_SPOP_SBC_1	0.3056
p.P1072S	DO50454	ESAD	ICGC	PKTSS	DEG_SPOP_SBC_1	0.1944
p.R1062H	DO233882	GACA	ICGC	PKTSS	DEG_SPOP_SBC_1	0.3056
p.R1062H	DO46374	OV	ICGC	PKTSS	DEG_SPOP_SBC_1	0.3056
p.A1057S	DO228986	LICA	ICGC	PKTSS	DEG_SPOP_SBC_1	0.1667
p.P1063T	DO227520	ORCA	ICGC	PKTSS	DEG_SPOP_SBC_1	0.7031
p.S1067N	SIDM01137	Pancreatic Carcinoma	GDSC	PKTSS	DEG_SPOP_SBC_1	0.7069
p.S1067N	ACH-000235	Pancreatic Cancer	CCLE	PKTSS	DEG_SPOP_SBC_1	0.7069
p.S1067N	PANC-04-03	pancreas	COSMIC	PKTSS	DEG_SPOP_SBC_1	0.7069
p.A1057T	ACH-000972	Endometrial/Uterine Cancer	CCLE	PKTSS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43303	Centriolar coiled-coil protein of 110 kDa	DEG_SPOP_SBC_1	188:192	PKTSS	SPOP	0.6385	More...
O43314	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	DEG_SPOP_SBC_1	489:493	PKTSS	SPOP	0.8197	More...
Q14966	Zinc finger protein 638	DEG_SPOP_SBC_1	610:614	PKTSS	SPOP	0.8762	More...
Q6ZT12	E3 ubiquitin-protein ligase UBR3	DEG_SPOP_SBC_1	1063:1067	PKTSS	SPOP	0.955	More...
Q6ZWJ1	Syntaxin-binding protein 4	DEG_SPOP_SBC_1	149:153	PKTSS	SPOP	0.8731	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	2822:2826	PKTSS	SPOP	0.9052	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	3053:3057	PKTSS	SPOP	0.8531	More...
Q96GS4	BLOC-1-related complex subunit 6	DEG_SPOP_SBC_1	62:66	PKTSS	SPOP	0.9347	More...
Q9BX26	Synaptonemal complex protein 2	DEG_SPOP_SBC_1	1141:1145	PKTSS	SPOP	0.958	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_SPOP_SBC_1	1292:1296	PKTSS	SPOP	0.6269	More...
Q9Y6B7	AP-4 complex subunit beta-1	DEG_SPOP_SBC_1	589:593	PKTSS	SPOP	0.9969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons