DegronMD - Q9BX26(SYCP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1134I	TCGA-5X-AA5U	OV	TCGA	PKTSS	DEG_SPOP_SBC_1	1141:1145	Mutation rewiring degron network	0.1389
p.T1134I	DO224035	OV	ICGC	PKTSS	DEG_SPOP_SBC_1	1141:1145	Mutation rewiring degron network	0.1389
p.E1045D	TCGA-85-A4JC	LUSC	TCGA	FKENI	DEG_APCC_KENBOX_2	1043:1047	Mutation altering degron motif	0.6758
p.E1045D	TCGA-DF-A2KU	UCEC	TCGA	FKENI	DEG_APCC_KENBOX_2	1043:1047	Mutation altering degron motif	0.6758
p.E1045D	DO45429	LUSC	ICGC	FKENI	DEG_APCC_KENBOX_2	1043:1047	Mutation altering degron motif	0.6758
p.E1045D	DO223286	UCEC	ICGC	FKENI	DEG_APCC_KENBOX_2	1043:1047	Mutation altering degron motif	0.6758
p.S635L	TCGA-A2-A0CT	BRCA	TCGA	ASTSS	DEG_SPOP_SBC_1	632:636	Mutation altering degron motif	0.7667
p.S635L	TCGA-B5-A11E	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	632:636	Mutation altering degron motif	0.7667
p.S635L	TCGA-B5-A11N	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	632:636	Mutation altering degron motif	0.7667
p.S635L	TCGA-EE-A3AE	SKCM	TCGA	ASTSS	DEG_SPOP_SBC_1	632:636	Mutation altering degron motif	0.7667
p.S635L	DO4780	BRCA	ICGC	ASTSS	DEG_SPOP_SBC_1	632:636	Mutation altering degron motif	0.7667
p.S635L	DO37802	SKCM	ICGC	ASTSS	DEG_SPOP_SBC_1	632:636	Mutation altering degron motif	0.7667
p.S635L	DO41644	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	632:636	Mutation altering degron motif	0.7667
p.S635L	DO41458	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	632:636	Mutation altering degron motif	0.7667
p.I646L	TCGA-A6-6780	COAD	TCGA	ASTSS	DEG_SPOP_SBC_1	632:636	Mutation rewiring degron network	0.0556
p.I646L	DO10244	COAD	ICGC	ASTSS	DEG_SPOP_SBC_1	632:636	Mutation rewiring degron network	0.0556
p.N641S	TCGA-A8-A090	BRCA	TCGA	ASTSS	DEG_SPOP_SBC_1	632:636	Mutation rewiring degron network	0.1944
p.N641S	DO1345	BRCA	ICGC	ASTSS	DEG_SPOP_SBC_1	632:636	Mutation rewiring degron network	0.1944
p.R1199K	TCGA-AP-A059	UCEC	TCGA	PRHTPTKS	DEG_SCF_FBW7_1	1186:1193	Mutation rewiring degron network	0.1667
p.R1199K	DO41361	UCEC	ICGC	PRHTPTKS	DEG_SCF_FBW7_1	1186:1193	Mutation rewiring degron network	0.1667
p.R1057I	TCGA-AX-A0J0	UCEC	TCGA	FKENI	DEG_APCC_KENBOX_2	1043:1047	Mutation rewiring degron network	0.0556
p.R1057I	DO41133	UCEC	ICGC	FKENI	DEG_APCC_KENBOX_2	1043:1047	Mutation rewiring degron network	0.0556
p.D922Y	TCGA-AX-A0J0	UCEC	TCGA	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation rewiring degron network	0.0833
p.D922Y	TCGA-EO-A3AV	UCEC	TCGA	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation rewiring degron network	0.0833
p.D922Y	TCGA-F4-6570	COAD	TCGA	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation rewiring degron network	0.0833
p.D922Y	DO10443	COAD	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation rewiring degron network	0.0833
p.D922Y	DO52412	UCEC	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation rewiring degron network	0.0833
p.D922Y	DO41133	UCEC	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation rewiring degron network	0.0833
p.D946Y	TCGA-AZ-4315	COAD	TCGA	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation rewiring degron network	0.0833
p.D946Y	DO8842	COAD	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation rewiring degron network	0.0833
p.K931N	TCGA-B5-A1MR	UCEC	TCGA	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation altering degron motif	0.6918
p.K931N	TCGA-EO-A22U	UCEC	TCGA	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation altering degron motif	0.6918
p.K931N	DO41758	UCEC	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation altering degron motif	0.6918
p.K931N	DO43755	UCEC	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation altering degron motif	0.6918
p.P1048Q	TCGA-BF-A1Q0	SKCM	TCGA	FKENI	DEG_APCC_KENBOX_2	1043:1047	Mutation rewiring degron network	0.3056
p.P1048Q	DO47374	SKCM	ICGC	FKENI	DEG_APCC_KENBOX_2	1043:1047	Mutation rewiring degron network	0.3056
p.P1180L	TCGA-BR-6458	STAD	TCGA	PRHTPTKS	DEG_SCF_FBW7_1	1186:1193	Mutation rewiring degron network	0.1667
p.P1180L	DO38296	STAD	ICGC	PRHTPTKS	DEG_SCF_FBW7_1	1186:1193	Mutation rewiring degron network	0.1667
p.R1181Q	TCGA-C8-A26X	BRCA	TCGA	PRHTPTKS	DEG_SCF_FBW7_1	1186:1193	Mutation rewiring degron network	0.1944
p.R1181Q	DO5549	BRCA	ICGC	PRHTPTKS	DEG_SCF_FBW7_1	1186:1193	Mutation rewiring degron network	0.1944
p.K932T	TCGA-D1-A103	UCEC	TCGA	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation altering degron motif	0.6195
p.K932T	DO42312	UCEC	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation altering degron motif	0.6195
p.S1138L	TCGA-DD-A73A	LIHC	TCGA	PKTSS	DEG_SPOP_SBC_1	1141:1145	Mutation blocking phosphorylation signal	0.6944
p.S1138L	TCGA-WE-A8ZX	SKCM	TCGA	PKTSS	DEG_SPOP_SBC_1	1141:1145	Mutation blocking phosphorylation signal	0.6944
p.S1138L	DO48478	LIHC	ICGC	PKTSS	DEG_SPOP_SBC_1	1141:1145	Mutation blocking phosphorylation signal	0.6944
p.S1138L	DO51291	SKCM	ICGC	PKTSS	DEG_SPOP_SBC_1	1141:1145	Mutation blocking phosphorylation signal	0.6944
p.R1199T	TCGA-E2-A14V	BRCA	TCGA	PRHTPTKS	DEG_SCF_FBW7_1	1186:1193	Mutation rewiring degron network	0.1667
p.R1199T	DO3548	BRCA	ICGC	PRHTPTKS	DEG_SCF_FBW7_1	1186:1193	Mutation rewiring degron network	0.1667
p.S1136Y	TCGA-E6-A1LX	UCEC	TCGA	PKTSS	DEG_SPOP_SBC_1	1141:1145	Mutation rewiring degron network	0.1944
p.S1136Y	DO41020	UCEC	ICGC	PKTSS	DEG_SPOP_SBC_1	1141:1145	Mutation rewiring degron network	0.1944
p.L640F	TCGA-E6-A1LX	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	632:636	Mutation rewiring degron network	0.2222
p.L640F	DO41020	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	632:636	Mutation rewiring degron network	0.2222
p.D937H	TCGA-EK-A3GK	CESC	TCGA	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation altering degron motif	0.7688
p.D937H	DO49964	CESC	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation altering degron motif	0.7688
p.D937H	DO27879	ORCA	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation altering degron motif	0.7688
p.A632S	TCGA-EO-A22R	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	632:636	Mutation altering degron motif	0.7588
p.A632S	DO42713	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	632:636	Mutation altering degron motif	0.7588
p.T639I	TCGA-EY-A1GD	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	632:636	Mutation rewiring degron network	0.25
p.T639I	DO42129	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	632:636	Mutation rewiring degron network	0.25
p.P1182S	TCGA-N8-A4PI	UCS	TCGA	PRHTPTKS	DEG_SCF_FBW7_1	1186:1193	Mutation rewiring degron network	0.2222
p.H1041P	DO222874	COCA	ICGC	FKENI	DEG_APCC_KENBOX_2	1043:1047	Mutation rewiring degron network	0.2778
p.K924T	DO50440	ESAD	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation substituting flanking lysine	0.25
p.E1045Q	DO234412	ESAD	ICGC	FKENI	DEG_APCC_KENBOX_2	1043:1047	Mutation altering degron motif	0.6744
p.D937A	DO233170	GACA	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation altering degron motif	0.7793
p.T634S	DO233215	GACA	ICGC	ASTSS	DEG_SPOP_SBC_1	632:636	Mutation altering degron motif	0.6005
p.A632T	DO233193	GACA	ICGC	ASTSS	DEG_SPOP_SBC_1	632:636	Mutation altering degron motif	0.7139
p.P1182T	DO228948	LICA	ICGC	PRHTPTKS	DEG_SCF_FBW7_1	1186:1193	Mutation rewiring degron network	0.2222
p.P1182T	DO229027	LICA	ICGC	PRHTPTKS	DEG_SCF_FBW7_1	1186:1193	Mutation rewiring degron network	0.2222
p.P1182T	DO229026	LICA	ICGC	PRHTPTKS	DEG_SCF_FBW7_1	1186:1193	Mutation rewiring degron network	0.2222
p.N1152K	DO228976	LICA	ICGC	PKTSS	DEG_SPOP_SBC_1	1141:1145	Mutation rewiring degron network	0.1389
p.H1041N	DO229028	LICA	ICGC	FKENI	DEG_APCC_KENBOX_2	1043:1047	Mutation rewiring degron network	0.2778
p.Q1037K	DO229034	LICA	ICGC	FKENI	DEG_APCC_KENBOX_2	1043:1047	Mutation rewiring degron network	0.1667
p.T927K	DO229035	LICA	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation rewiring degron network	0.2222
p.I926L	DO50894	LICA	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation rewiring degron network	0.1944
p.Q642K	DO231593	LINC	ICGC	ASTSS	DEG_SPOP_SBC_1	632:636	Mutation rewiring degron network	0.1667
p.S1148Y	DO23174	LINC	ICGC	PKTSS	DEG_SPOP_SBC_1	1141:1145	Mutation rewiring degron network	0.25
p.S1177L	DO231212	LUSC	ICGC	PRHTPTKS	DEG_SCF_FBW7_1	1186:1193	Mutation rewiring degron network	0.0833
p.K1200Q	DO222363	MELA	ICGC	PRHTPTKS	DEG_SCF_FBW7_1	1186:1193	Mutation substituting flanking lysine	0.25
p.E1045K	DO222567	MELA	ICGC	FKENI	DEG_APCC_KENBOX_2	1043:1047	Mutation altering degron motif	0.7022
p.I925T	SIDM00394	Cervical Carcinoma	GDSC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation rewiring degron network	0.1667
p.I925T	SISO	cervix	COSMIC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation rewiring degron network	0.1667
p.K1200E	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	PRHTPTKS	DEG_SCF_FBW7_1	1186:1193	Mutation substituting flanking lysine	0.25
p.P1190L	SIDM00974	Melanoma	GDSC	PRHTPTKS	DEG_SCF_FBW7_1	1186:1193	Mutation altering degron motif	0.7582
p.P1190L	ACH-002207	Skin Cancer	CCLE	PRHTPTKS	DEG_SCF_FBW7_1	1186:1193	Mutation altering degron motif	0.7582
p.P1190L	WM35	skin	COSMIC	PRHTPTKS	DEG_SCF_FBW7_1	1186:1193	Mutation altering degron motif	0.7582
p.E941K	SIDM01048	Plasma Cell Myeloma	GDSC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation rewiring degron network	0.2222
p.E941K	ACH-000821	Myeloma	CCLE	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation rewiring degron network	0.2222
p.E941K	EJM	haematopoietic and lymphoid tissue	COSMIC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation rewiring degron network	0.2222
p.V645A	SIDM00217	Colorectal Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	632:636	Mutation rewiring degron network	0.0833
p.V645A	ACH-000999	Colon/Colorectal Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	632:636	Mutation rewiring degron network	0.0833
p.V645A	SNU-1040	large intestine	COSMIC	ASTSS	DEG_SPOP_SBC_1	632:636	Mutation rewiring degron network	0.0833
p.I925M	SIDM01611	Endometrial Carcinoma	GDSC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation rewiring degron network	0.1667
p.I925M	ACH-000996	Endometrial/Uterine Cancer	CCLE	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation rewiring degron network	0.1667
p.I926T	ACH-000877	Lymphoma	CCLE	KKNLFSD	LIG_APCC_ABBAyCdc20_2	931:937	Mutation rewiring degron network	0.1944
p.E1034Q	ACH-001395	Breast Cancer	CCLE	FKENI	DEG_APCC_KENBOX_2	1043:1047	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYCP2

UniProt ID: Q9BX26

Entrez ID: 10388

Protein name: Synaptonemal complex protein 2 (SCP-2) (Synaptonemal complex lateral element protein) (hsSCP2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYCP2 in