DegronMD

Uniprot ID: Q9BX26

Source protein: Synaptonemal complex protein 2

Source gene: SYCP2

Class: LIG_APCC_ABBAyCdc20_2

Location: 931:937

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.968

ASA_SCORE: 102.1429

COIL: 0.7991

CONS_SCORE: 0.5391

DSS_SCORE: 0.4028

HELIX: 0.147

FCONS_SCORE: 1.1538

RIG_SCORE: 0.7523

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D922Y	TCGA-AX-A0J0	UCEC	TCGA	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.D922Y	TCGA-EO-A3AV	UCEC	TCGA	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.D922Y	TCGA-F4-6570	COAD	TCGA	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.D922Y	DO10443	COAD	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.D922Y	DO52412	UCEC	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.D922Y	DO41133	UCEC	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.D946Y	TCGA-AZ-4315	COAD	TCGA	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.D946Y	DO8842	COAD	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.K931N	TCGA-B5-A1MR	UCEC	TCGA	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.6918
p.K931N	TCGA-EO-A22U	UCEC	TCGA	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.6918
p.K931N	DO41758	UCEC	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.6918
p.K931N	DO43755	UCEC	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.6918
p.K932T	TCGA-D1-A103	UCEC	TCGA	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.6195
p.K932T	DO42312	UCEC	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.6195
p.D937H	TCGA-EK-A3GK	CESC	TCGA	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.7688
p.D937H	DO49964	CESC	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.7688
p.D937H	DO27879	ORCA	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.7688
p.K924T	DO50440	ESAD	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.25
p.D937A	DO233170	GACA	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.7793
p.T927K	DO229035	LICA	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.I926L	DO50894	LICA	ICGC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.I925T	SIDM00394	Cervical Carcinoma	GDSC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.I925T	SISO	cervix	COSMIC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.E941K	SIDM01048	Plasma Cell Myeloma	GDSC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E941K	ACH-000821	Myeloma	CCLE	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E941K	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.I925M	SIDM01611	Endometrial Carcinoma	GDSC	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.I925M	ACH-000996	Endometrial/Uterine Cancer	CCLE	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.I926T	ACH-000877	Lymphoma	CCLE	KKNLFSD	LIG_APCC_ABBAyCdc20_2	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KKNLFSD

Degron related mutations and impact score

Drug responses associated with SYCP2 mutations

All proteins holding degron of KKNLFSD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BX26	Synaptonemal complex protein 2	LIG_APCC_ABBAyCdc20_2	931:937	KKNLFSD	APC,CDC20,FZR1	0.968	More...