DegronMD

Uniprot ID: Q9BX26

Source protein: Synaptonemal complex protein 2

Source gene: SYCP2

Class: DEG_SCF_FBW7_1

Location: 1186:1193

E3 ligase: FBXW7

DEGRON score: 0.9813

ASA_SCORE: 116.65

COIL: 0.9609

CONS_SCORE: 0.3239

DSS_SCORE: 0.4903

HELIX: 0.0169

FCONS_SCORE: 0.9335

RIG_SCORE: 0.7031

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1199K	TCGA-AP-A059	UCEC	TCGA	PRHTPTKS	DEG_SCF_FBW7_1	0.1667
p.R1199K	DO41361	UCEC	ICGC	PRHTPTKS	DEG_SCF_FBW7_1	0.1667
p.P1180L	TCGA-BR-6458	STAD	TCGA	PRHTPTKS	DEG_SCF_FBW7_1	0.1667
p.P1180L	DO38296	STAD	ICGC	PRHTPTKS	DEG_SCF_FBW7_1	0.1667
p.R1181Q	TCGA-C8-A26X	BRCA	TCGA	PRHTPTKS	DEG_SCF_FBW7_1	0.1944
p.R1181Q	DO5549	BRCA	ICGC	PRHTPTKS	DEG_SCF_FBW7_1	0.1944
p.R1199T	TCGA-E2-A14V	BRCA	TCGA	PRHTPTKS	DEG_SCF_FBW7_1	0.1667
p.R1199T	DO3548	BRCA	ICGC	PRHTPTKS	DEG_SCF_FBW7_1	0.1667
p.P1182S	TCGA-N8-A4PI	UCS	TCGA	PRHTPTKS	DEG_SCF_FBW7_1	0.2222
p.P1182T	DO228948	LICA	ICGC	PRHTPTKS	DEG_SCF_FBW7_1	0.2222
p.P1182T	DO229027	LICA	ICGC	PRHTPTKS	DEG_SCF_FBW7_1	0.2222
p.P1182T	DO229026	LICA	ICGC	PRHTPTKS	DEG_SCF_FBW7_1	0.2222
p.S1177L	DO231212	LUSC	ICGC	PRHTPTKS	DEG_SCF_FBW7_1	0.0833
p.K1200Q	DO222363	MELA	ICGC	PRHTPTKS	DEG_SCF_FBW7_1	0.25
p.K1200E	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	PRHTPTKS	DEG_SCF_FBW7_1	0.25
p.P1190L	SIDM00974	Melanoma	GDSC	PRHTPTKS	DEG_SCF_FBW7_1	0.7582
p.P1190L	ACH-002207	Skin Cancer	CCLE	PRHTPTKS	DEG_SCF_FBW7_1	0.7582
p.P1190L	WM35	skin	COSMIC	PRHTPTKS	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BX26	Synaptonemal complex protein 2	DEG_SCF_FBW7_1	1186:1193	PRHTPTKS	FBXW7	0.9813	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons