DegronMD

Uniprot ID: Q9BX26

Source protein: Synaptonemal complex protein 2

Source gene: SYCP2

Class: DEG_APCC_KENBOX_2

Location: 1043:1047

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9572

ASA_SCORE: 116.26

COIL: 0.7314

CONS_SCORE: 0.3715

DSS_SCORE: 0.4693

HELIX: 0.229

FCONS_SCORE: 0.8888

RIG_SCORE: 0.7063

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1045D	TCGA-85-A4JC	LUSC	TCGA	FKENI	DEG_APCC_KENBOX_2	0.6758
p.E1045D	TCGA-DF-A2KU	UCEC	TCGA	FKENI	DEG_APCC_KENBOX_2	0.6758
p.E1045D	DO45429	LUSC	ICGC	FKENI	DEG_APCC_KENBOX_2	0.6758
p.E1045D	DO223286	UCEC	ICGC	FKENI	DEG_APCC_KENBOX_2	0.6758
p.R1057I	TCGA-AX-A0J0	UCEC	TCGA	FKENI	DEG_APCC_KENBOX_2	0.0556
p.R1057I	DO41133	UCEC	ICGC	FKENI	DEG_APCC_KENBOX_2	0.0556
p.P1048Q	TCGA-BF-A1Q0	SKCM	TCGA	FKENI	DEG_APCC_KENBOX_2	0.3056
p.P1048Q	DO47374	SKCM	ICGC	FKENI	DEG_APCC_KENBOX_2	0.3056
p.H1041P	DO222874	COCA	ICGC	FKENI	DEG_APCC_KENBOX_2	0.2778
p.E1045Q	DO234412	ESAD	ICGC	FKENI	DEG_APCC_KENBOX_2	0.6744
p.H1041N	DO229028	LICA	ICGC	FKENI	DEG_APCC_KENBOX_2	0.2778
p.Q1037K	DO229034	LICA	ICGC	FKENI	DEG_APCC_KENBOX_2	0.1667
p.E1045K	DO222567	MELA	ICGC	FKENI	DEG_APCC_KENBOX_2	0.7022
p.E1034Q	ACH-001395	Breast Cancer	CCLE	FKENI	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92540	Nonsense-mediated mRNA decay factor SMG7	DEG_APCC_KENBOX_2	547:551	FKENI	APC,CDC20,FZR1	0.7656	More...
Q9BX26	Synaptonemal complex protein 2	DEG_APCC_KENBOX_2	1043:1047	FKENI	APC,CDC20,FZR1	0.9572	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons