DegronMD - Q92540(SMG7)

FUNCTION: Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. {ECO:0000269|PubMed:15546618, ECO:0000269|PubMed:15721257}.

GO - Biological processes (BP): mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of dephosphorylation [GO:0035303]

GO - Molecular function (MF): protein phosphatase 2A binding [GO:0051721]; telomerase RNA binding [GO:0070034]; telomeric DNA binding [GO:0042162]

GO - Cellular component (CC): cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1064H	DO41361	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	1063:1067	Mutation altering degron motif	0.7694
p.S1066L	TCGA-EM-A3O3	THCA	TCGA	ATSSS	DEG_SPOP_SBC_1	1063:1067	Mutation altering degron motif	0.7667
p.Q628H	DO229031	LICA	ICGC	LRKTPVSE	DEG_SCF_FBW7_2	621:628	Mutation altering degron motif	0.7582
p.S530R	SIDM00169	Head and Neck Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.7427
p.S530R	ACH-000692	Head and Neck Cancer	CCLE	VLSTS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.7427
p.R864K	DO29578	OV	ICGC	SEVKVPEF	DEG_COP1_1	862:869	Mutation altering degron motif	0.7237
p.H669Y	TCGA-B5-A11E	UCEC	TCGA	PPTY	ITCH	666:669	Mutation altering degron motif	0.7229
p.K524I	TCGA-2Z-A9J6	KIRP	TCGA	VLSTS	DEG_SPOP_SBC_1	526:530	Mutation blocking ubiquitination signal	0.7222
p.G534R	DO27468	LUSC	ICGC	NCDTGE	DEG_Kelch_Keap1_1	536:541	Mutation blocking phosphorylation signal	0.7222
p.S534G	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	NCDTGE	DEG_Kelch_Keap1_1	536:541	Mutation blocking phosphorylation signal	0.7222
p.S534G	ACH-002102	Lung Cancer	CCLE	NCDTGE	DEG_Kelch_Keap1_1	536:541	Mutation blocking phosphorylation signal	0.7222
p.S534G	EMC-BAC-2	lung	COSMIC	NCDTGE	DEG_Kelch_Keap1_1	536:541	Mutation blocking phosphorylation signal	0.7222
p.D538G	TCGA-KK-A59V	PRAD	TCGA	NCDTGE	DEG_Kelch_Keap1_1	536:541	Mutation altering degron motif	0.7198
p.A624T	DO41791	UCEC	ICGC	LRKTPVSE	DEG_SCF_FBW7_2	621:628	Mutation altering degron motif	0.7139
p.T622S	TCGA-21-1078	LUSC	TCGA	LRKTPVSE	DEG_SCF_FBW7_2	621:628	Mutation altering degron motif	0.7116
p.I1065T	DO222897	BTCA	ICGC	ATSSS	DEG_SPOP_SBC_1	1063:1067	Mutation altering degron motif	0.7078
p.P621T	DO37738	SKCM	ICGC	LRKTPVSE	DEG_SCF_FBW7_2	621:628	Mutation altering degron motif	0.7031
p.K550E	DO51749	STAD	ICGC	FKENI	DEG_APCC_KENBOX_2	547:551	Mutation altering degron motif	0.7022
p.N536K	ACH-001061	Colon/Colorectal Cancer	CCLE	NCDTGE	DEG_Kelch_Keap1_1	536:541	Mutation altering degron motif	0.6918
p.S753P	DO219881	SKCA	ICGC	AQSTS	DEG_SPOP_SBC_1	753:757	Mutation altering degron motif	0.6752

Showing 1 to 20 of 125 entries

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No resistance data available for this Degron.

Kaplan plot for SMG7 in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMG7

UniProt ID: Q92540

Entrez ID: 9887

Protein name: Nonsense-mediated mRNA decay factor SMG7 (SMG-7 homolog) (hSMG-7)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for SMG7 in