DegronMD - Q92540(SMG7)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T622S	TCGA-21-1078	LUSC	TCGA	LRKTPVSE	DEG_SCF_FBW7_2	621:628	Mutation altering degron motif	0.7116
p.K524I	TCGA-2Z-A9J6	KIRP	TCGA	VLSTS	DEG_SPOP_SBC_1	526:530	Mutation blocking ubiquitination signal	0.7222
p.P861S	TCGA-39-5028	LUSC	TCGA	SEVKVPEF	DEG_COP1_1	862:869	Mutation rewiring degron network	0.3056
p.Q859H	TCGA-44-7659	LUAD	TCGA	SEVKVPEF	DEG_COP1_1	862:869	Mutation rewiring degron network	0.25
p.Q747R	TCGA-56-A49D	LUSC	TCGA	AQSTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.1667
p.G634V	TCGA-95-7039	LUAD	TCGA	LRKTPVSE	DEG_SCF_FBW7_2	621:628	Mutation rewiring degron network	0.1667
p.R531Q	TCGA-A8-A06Q	BRCA	TCGA	NCDTGE	DEG_Kelch_Keap1_1	536:541	Mutation rewiring degron network	0.1944
p.R531Q	TCGA-A8-A06Q	BRCA	TCGA	VLSTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.3056
p.R531Q	TCGA-EO-A22X	UCEC	TCGA	NCDTGE	DEG_Kelch_Keap1_1	536:541	Mutation rewiring degron network	0.1944
p.R531Q	TCGA-EO-A22X	UCEC	TCGA	VLSTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.3056
p.R531Q	ACH-000993	Endometrial/Uterine Cancer	CCLE	NCDTGE	DEG_Kelch_Keap1_1	536:541	Mutation rewiring degron network	0.1944
p.R531Q	ACH-000993	Endometrial/Uterine Cancer	CCLE	VLSTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.3056
p.P619L	TCGA-AA-3864	COAD	TCGA	LRKTPVSE	DEG_SCF_FBW7_2	621:628	Mutation rewiring degron network	0.2778
p.N532H	TCGA-AY-A54L	COAD	TCGA	NCDTGE	DEG_Kelch_Keap1_1	536:541	Mutation rewiring degron network	0.2222
p.N532H	TCGA-AY-A54L	COAD	TCGA	VLSTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2778
p.H669Y	TCGA-B5-A11E	UCEC	TCGA	PPTY	ITCH	666:669	Mutation altering degron motif	0.7229
p.P671S	TCGA-BF-A5EQ	SKCM	TCGA	PPTY	ITCH	666:669	Mutation rewiring degron network	0.2778
p.P671S	TCGA-DA-A960	SKCM	TCGA	PPTY	ITCH	666:669	Mutation rewiring degron network	0.2778
p.P861H	TCGA-D1-A17D	UCEC	TCGA	SEVKVPEF	DEG_COP1_1	862:869	Mutation rewiring degron network	0.3056
p.P613S	TCGA-DY-A1DG	READ	TCGA	LRKTPVSE	DEG_SCF_FBW7_2	621:628	Mutation rewiring degron network	0.1111
p.G1059V	TCGA-EE-A3AC	SKCM	TCGA	ATSSS	DEG_SPOP_SBC_1	1063:1067	Mutation rewiring degron network	0.2222
p.S1066L	TCGA-EM-A3O3	THCA	TCGA	ATSSS	DEG_SPOP_SBC_1	1063:1067	Mutation altering degron motif	0.7667
p.P671L	TCGA-FR-A726	SKCM	TCGA	PPTY	ITCH	666:669	Mutation rewiring degron network	0.2778
p.G765V	TCGA-G3-A5SL	LIHC	TCGA	AQSTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.1111
p.D538G	TCGA-KK-A59V	PRAD	TCGA	NCDTGE	DEG_Kelch_Keap1_1	536:541	Mutation altering degron motif	0.7198
p.P677S	TCGA-WE-AAA0	SKCM	TCGA	PPTY	ITCH	666:669	Mutation rewiring degron network	0.1111
p.A516T	TCGA-ZJ-A8QR	CESC	TCGA	VLSTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.0556
p.Q761K	TCGA-ZJ-AB0I	CESC	TCGA	AQSTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.2222
p.S1073R	TCGA-ZS-A9CD	LIHC	TCGA	ATSSS	DEG_SPOP_SBC_1	1063:1067	Mutation rewiring degron network	0.1667
p.R1073K	DO856	BLCA	ICGC	ATSSS	DEG_SPOP_SBC_1	1063:1067	Mutation rewiring degron network	0.1667
p.H767Y	DO218986	BLCA	ICGC	AQSTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.0556
p.K554N	DO1285	BRCA	ICGC	FKENI	DEG_APCC_KENBOX_2	547:551	Mutation rewiring degron network	0.25
p.R560Q	DO1263	BRCA	ICGC	FKENI	DEG_APCC_KENBOX_2	547:551	Mutation rewiring degron network	0.0833
p.R560Q	DO43907	UCEC	ICGC	FKENI	DEG_APCC_KENBOX_2	547:551	Mutation rewiring degron network	0.0833
p.I1065T	DO222897	BTCA	ICGC	ATSSS	DEG_SPOP_SBC_1	1063:1067	Mutation altering degron motif	0.7078
p.A545T	DO219749	CESC	ICGC	FKENI	DEG_APCC_KENBOX_2	547:551	Mutation rewiring degron network	0.2778
p.A545T	DO219749	CESC	ICGC	NCDTGE	DEG_Kelch_Keap1_1	536:541	Mutation rewiring degron network	0.2222
p.L747V	DO219732	CESC	ICGC	AQSTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.1667
p.N561H	DO44091	COAD	ICGC	FKENI	DEG_APCC_KENBOX_2	547:551	Mutation rewiring degron network	0.0556
p.S559N	DO8730	COAD	ICGC	FKENI	DEG_APCC_KENBOX_2	547:551	Mutation rewiring degron network	0.1111
p.K553I	DO219656	KIRP	ICGC	FKENI	DEG_APCC_KENBOX_2	547:551	Mutation rewiring degron network	0.2778
p.G877C	DO228974	LICA	ICGC	SEVKVPEF	DEG_COP1_1	862:869	Mutation rewiring degron network	0.1111
p.A546S	DO229028	LICA	ICGC	FKENI	DEG_APCC_KENBOX_2	547:551	Mutation rewiring degron network	0.3056
p.A546S	DO229028	LICA	ICGC	NCDTGE	DEG_Kelch_Keap1_1	536:541	Mutation rewiring degron network	0.1944
p.Q628H	DO229031	LICA	ICGC	LRKTPVSE	DEG_SCF_FBW7_2	621:628	Mutation altering degron motif	0.7582
p.G663V	DO23907	LUAD	ICGC	PPTY	ITCH	666:669	Mutation rewiring degron network	0.25
p.G534R	DO27468	LUSC	ICGC	NCDTGE	DEG_Kelch_Keap1_1	536:541	Mutation blocking phosphorylation signal	0.7222
p.G534R	DO27468	LUSC	ICGC	VLSTS	DEG_SPOP_SBC_1	526:530	Mutation blocking phosphorylation signal	0.6667
p.P766L	DO220877	MELA	ICGC	AQSTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.0833
p.P765L	DO220911	MELA	ICGC	AQSTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.1111
p.R864K	DO29578	OV	ICGC	SEVKVPEF	DEG_COP1_1	862:869	Mutation altering degron motif	0.7237
p.T618I	DO46657	PAAD	ICGC	LRKTPVSE	DEG_SCF_FBW7_2	621:628	Mutation rewiring degron network	0.25
p.F660I	DO35242	PACA	ICGC	PPTY	ITCH	666:669	Mutation rewiring degron network	0.1667
p.L535M	DO36556	READ	ICGC	NCDTGE	DEG_Kelch_Keap1_1	536:541	Mutation rewiring degron network	0.3056
p.L535M	DO36556	READ	ICGC	VLSTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.1944
p.S1060F	DO220056	SARC	ICGC	ATSSS	DEG_SPOP_SBC_1	1063:1067	Mutation rewiring degron network	0.25
p.S1060F	SK-MEL-2	skin	COSMIC	ATSSS	DEG_SPOP_SBC_1	1063:1067	Mutation rewiring degron network	0.25
p.S753P	DO219881	SKCA	ICGC	AQSTS	DEG_SPOP_SBC_1	753:757	Mutation altering degron motif	0.6752
p.P621T	DO37738	SKCM	ICGC	LRKTPVSE	DEG_SCF_FBW7_2	621:628	Mutation altering degron motif	0.7031
p.H633Y	DO219501	SKCM	ICGC	LRKTPVSE	DEG_SCF_FBW7_2	621:628	Mutation rewiring degron network	0.1944
p.K550E	DO51749	STAD	ICGC	FKENI	DEG_APCC_KENBOX_2	547:551	Mutation altering degron motif	0.7022
p.R875C	DO42201	UCEC	ICGC	SEVKVPEF	DEG_COP1_1	862:869	Mutation rewiring degron network	0.1667
p.A746T	DO41752	UCEC	ICGC	AQSTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.1389
p.S865P	DO52402	UCEC	ICGC	SEVKVPEF	DEG_COP1_1	862:869	Mutation altering degron motif	0.6752
p.T620S	DO41608	UCEC	ICGC	LRKTPVSE	DEG_SCF_FBW7_2	621:628	Mutation rewiring degron network	0.3056
p.A624T	DO41791	UCEC	ICGC	LRKTPVSE	DEG_SCF_FBW7_2	621:628	Mutation altering degron motif	0.7139
p.F852L	DO41211	UCEC	ICGC	SEVKVPEF	DEG_COP1_1	862:869	Mutation rewiring degron network	0.0556
p.A746V	DO41434	UCEC	ICGC	AQSTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.1389
p.P1064H	DO41361	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	1063:1067	Mutation altering degron motif	0.7694
p.Y858C	DO41331	UCEC	ICGC	SEVKVPEF	DEG_COP1_1	862:869	Mutation rewiring degron network	0.2222
p.G762C	SIDM02026	Colorectal Carcinoma	GDSC	AQSTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.1944
p.G762S	SIDM00845	Burkitt's Lymphoma	GDSC	AQSTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.1944
p.G762S	SIDM00035	Thyroid Gland Carcinoma	GDSC	AQSTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.1944
p.G762S	SIDM01519	Head and Neck Carcinoma	GDSC	AQSTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.1944
p.G762S	S-117	soft tissue	COSMIC	AQSTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.1944
p.S1073I	SIDM01090	Colorectal Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	1063:1067	Mutation rewiring degron network	0.1667
p.S1073I	RKO	large intestine	COSMIC	ATSSS	DEG_SPOP_SBC_1	1063:1067	Mutation rewiring degron network	0.1667
p.P877S	SIDM00007	Other Solid Cancers	GDSC	SEVKVPEF	DEG_COP1_1	862:869	Mutation rewiring degron network	0.1111
p.P877S	MCC13	skin	COSMIC	SEVKVPEF	DEG_COP1_1	862:869	Mutation rewiring degron network	0.1111
p.L558F	SIDM01129	Small Cell Lung Carcinoma	GDSC	FKENI	DEG_APCC_KENBOX_2	547:551	Mutation rewiring degron network	0.1389
p.L558F	NCI-H524	lung	COSMIC	FKENI	DEG_APCC_KENBOX_2	547:551	Mutation rewiring degron network	0.1389
p.T1068M	SIDM00835	Colorectal Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	1063:1067	Mutation rewiring degron network	0.3056
p.T1068M	SIDM00847	Rhabdomyosarcoma	GDSC	ATSSS	DEG_SPOP_SBC_1	1063:1067	Mutation rewiring degron network	0.3056
p.T1068M	RD	soft tissue	COSMIC	ATSSS	DEG_SPOP_SBC_1	1063:1067	Mutation rewiring degron network	0.3056
p.T1068M	SW1116	large intestine	COSMIC	ATSSS	DEG_SPOP_SBC_1	1063:1067	Mutation rewiring degron network	0.3056
p.S534G	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	NCDTGE	DEG_Kelch_Keap1_1	536:541	Mutation blocking phosphorylation signal	0.7222
p.S534G	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	526:530	Mutation blocking phosphorylation signal	0.6667
p.S534G	ACH-002102	Lung Cancer	CCLE	NCDTGE	DEG_Kelch_Keap1_1	536:541	Mutation blocking phosphorylation signal	0.7222
p.S534G	ACH-002102	Lung Cancer	CCLE	VLSTS	DEG_SPOP_SBC_1	526:530	Mutation blocking phosphorylation signal	0.6667
p.S534G	EMC-BAC-2	lung	COSMIC	NCDTGE	DEG_Kelch_Keap1_1	536:541	Mutation blocking phosphorylation signal	0.7222
p.S534G	EMC-BAC-2	lung	COSMIC	VLSTS	DEG_SPOP_SBC_1	526:530	Mutation blocking phosphorylation signal	0.6667
p.R856S	SIDM01045	Endometrial Carcinoma	GDSC	SEVKVPEF	DEG_COP1_1	862:869	Mutation rewiring degron network	0.1667
p.R856S	EN	endometrium	COSMIC	SEVKVPEF	DEG_COP1_1	862:869	Mutation rewiring degron network	0.1667
p.V545A	SIDM00221	Melanoma	GDSC	FKENI	DEG_APCC_KENBOX_2	547:551	Mutation rewiring degron network	0.2778
p.V545A	SIDM00221	Melanoma	GDSC	NCDTGE	DEG_Kelch_Keap1_1	536:541	Mutation rewiring degron network	0.2222
p.V545A	ACH-002388	Skin Cancer	CCLE	FKENI	DEG_APCC_KENBOX_2	547:551	Mutation rewiring degron network	0.2778
p.V545A	ACH-002388	Skin Cancer	CCLE	NCDTGE	DEG_Kelch_Keap1_1	536:541	Mutation rewiring degron network	0.2222
p.G519R	SIDM00196	Ewing's Sarcoma	GDSC	VLSTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.1389
p.S530R	SIDM00169	Head and Neck Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.7427
p.S530R	ACH-000692	Head and Neck Cancer	CCLE	VLSTS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.7427
p.S520N	ACH-000436	Myeloma	CCLE	VLSTS	DEG_SPOP_SBC_1	526:530	Mutation blocking phosphorylation signal	0.6111
p.S1069I	ACH-000943	Colon/Colorectal Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	1063:1067	Mutation rewiring degron network	0.2778
p.S1069I	RKO	large intestine	COSMIC	ATSSS	DEG_SPOP_SBC_1	1063:1067	Mutation rewiring degron network	0.2778
p.A878V	ACH-000973	Bladder Cancer	CCLE	SEVKVPEF	DEG_COP1_1	862:869	Mutation rewiring degron network	0.0833
p.N536K	ACH-001061	Colon/Colorectal Cancer	CCLE	NCDTGE	DEG_Kelch_Keap1_1	536:541	Mutation altering degron motif	0.6918
p.S874C	ACH-002123	Lung Cancer	CCLE	SEVKVPEF	DEG_COP1_1	862:869	Mutation rewiring degron network	0.1944
p.S874C	H2369	pleura	COSMIC	SEVKVPEF	DEG_COP1_1	862:869	Mutation rewiring degron network	0.1944
p.P656S	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPTY	ITCH	666:669	Mutation rewiring degron network	0.0556
p.P656S	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PPTY	ITCH	666:669	Mutation rewiring degron network	0.0556
p.P656S	DND-41	haematopoietic and lymphoid tissue	COSMIC	PPTY	ITCH	666:669	Mutation rewiring degron network	0.0556
p.P656S	S-117	soft tissue	COSMIC	PPTY	ITCH	666:669	Mutation rewiring degron network	0.0556
p.S1077I	RKO	large intestine	COSMIC	ATSSS	DEG_SPOP_SBC_1	1063:1067	Mutation rewiring degron network	0.0556
p.P631L	CP66-MEL	skin	COSMIC	LRKTPVSE	DEG_SCF_FBW7_2	621:628	Mutation substituting flanking lysine	0.3611
p.T765A	Daudi	haematopoietic and lymphoid tissue	COSMIC	AQSTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.1111
p.S521R	AGS	stomach	COSMIC	VLSTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.1944
p.T1064M	RD	soft tissue	COSMIC	ATSSS	DEG_SPOP_SBC_1	1063:1067	Mutation altering degron motif	0.6312
p.T1064M	SW1116	large intestine	COSMIC	ATSSS	DEG_SPOP_SBC_1	1063:1067	Mutation altering degron motif	0.6312
p.R875H	TE-4	oesophagus	COSMIC	SEVKVPEF	DEG_COP1_1	862:869	Mutation rewiring degron network	0.1667
p.S857C	H2369	pleura	COSMIC	SEVKVPEF	DEG_COP1_1	862:869	Mutation rewiring degron network	0.1944
p.F746V	23132-87	stomach	COSMIC	AQSTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.1389
p.T748A	Daudi	haematopoietic and lymphoid tissue	COSMIC	AQSTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.1944
p.R860S	EN	endometrium	COSMIC	SEVKVPEF	DEG_COP1_1	862:869	Mutation rewiring degron network	0.2778
p.T1072M	RD	soft tissue	COSMIC	ATSSS	DEG_SPOP_SBC_1	1063:1067	Mutation rewiring degron network	0.1944
p.T1072M	SW1116	large intestine	COSMIC	ATSSS	DEG_SPOP_SBC_1	1063:1067	Mutation rewiring degron network	0.1944
p.G766S	S-117	soft tissue	COSMIC	AQSTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMG7

UniProt ID: Q92540

Entrez ID: 9887

Protein name: Nonsense-mediated mRNA decay factor SMG7 (SMG-7 homolog) (hSMG-7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMG7 in