DegronMD

Uniprot ID: Q92540

Source protein: Nonsense-mediated mRNA decay factor SMG7

Source gene: SMG7

Class: DEG_SPOP_SBC_1

Location: 526:530

E3 ligase: SPOP

DEGRON score: 0.9999

ASA_SCORE: 75.28

COIL: 0.796

CONS_SCORE: 0.354

DSS_SCORE: 0.4562

HELIX: 0.1162

FCONS_SCORE: 1.0966

RIG_SCORE: 0.7292

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S530R	SIDM00169	Head and Neck Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.7427
p.S530R	ACH-000692	Head and Neck Cancer	CCLE	VLSTS	DEG_SPOP_SBC_1	0.7427
p.K524I	TCGA-2Z-A9J6	KIRP	TCGA	VLSTS	DEG_SPOP_SBC_1	0.7222
p.G534R	DO27468	LUSC	ICGC	VLSTS	DEG_SPOP_SBC_1	0.6667
p.S534G	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.6667
p.S534G	ACH-002102	Lung Cancer	CCLE	VLSTS	DEG_SPOP_SBC_1	0.6667
p.S534G	EMC-BAC-2	lung	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.6667
p.S520N	ACH-000436	Myeloma	CCLE	VLSTS	DEG_SPOP_SBC_1	0.6111
p.R531Q	TCGA-A8-A06Q	BRCA	TCGA	VLSTS	DEG_SPOP_SBC_1	0.3056
p.R531Q	TCGA-EO-A22X	UCEC	TCGA	VLSTS	DEG_SPOP_SBC_1	0.3056
p.R531Q	ACH-000993	Endometrial/Uterine Cancer	CCLE	VLSTS	DEG_SPOP_SBC_1	0.3056
p.N532H	TCGA-AY-A54L	COAD	TCGA	VLSTS	DEG_SPOP_SBC_1	0.2778
p.L535M	DO36556	READ	ICGC	VLSTS	DEG_SPOP_SBC_1	0.1944
p.S521R	AGS	stomach	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.1944
p.G519R	SIDM00196	Ewing's Sarcoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.1389
p.A516T	TCGA-ZJ-A8QR	CESC	TCGA	VLSTS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 16 of 16 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	334:338	VLSTS	SPOP	0.5966	More...
Q7Z460	CLIP-associating protein 1	DEG_SPOP_SBC_1	793:797	VLSTS	SPOP	0.9931	More...
Q6ZMZ0	E3 ubiquitin-protein ligase RNF19B	DEG_SPOP_SBC_1	492:496	VLSTS	SPOP	0.944	More...
Q8TEJ3	E3 ubiquitin-protein ligase SH3RF3	DEG_SPOP_SBC_1	696:700	VLSTS	SPOP	0.9715	More...
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1481:1485	VLSTS	SPOP	0.7831	More...
Q6IPM2	IQ domain-containing protein E	DEG_SPOP_SBC_1	318:322	VLSTS	SPOP	0.5759	More...
Q32MK0	Myosin light chain kinase 3	DEG_SPOP_SBC_1	174:178	VLSTS	SPOP	0.9947	More...
Q92540	Nonsense-mediated mRNA decay factor SMG7	DEG_SPOP_SBC_1	526:530	VLSTS	SPOP	0.9999	More...
Q9UNZ2	NSFL1 cofactor p47	DEG_SPOP_SBC_1	267:271	VLSTS	SPOP	0.7502	More...
Q96LA8	Protein arginine N-methyltransferase 6	DEG_SPOP_SBC_1	306:310	VLSTS	SPOP	0.5624	More...
Q5T8P6	RNA-binding protein 26	DEG_SPOP_SBC_1	687:691	VLSTS	SPOP	0.5563	More...
Q7KZI7	Serine/threonine-protein kinase MARK2	DEG_SPOP_SBC_1	475:479	VLSTS	SPOP	0.9918	More...
Q9P275	Ubiquitin carboxyl-terminal hydrolase 36	DEG_SPOP_SBC_1	578:582	VLSTS	SPOP	0.9967	More...
Q9H0E7	Ubiquitin carboxyl-terminal hydrolase 44	DEG_SPOP_SBC_1	245:249	VLSTS	SPOP	0.9886	More...

Showing 1 to 14 of 14 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons