DegronMD

Uniprot ID: P16144

Source protein: Integrin beta-4

Source gene: ITGB4

Class: DEG_SPOP_SBC_1

Location: 1481:1485

E3 ligase: SPOP

DEGRON score: 0.7831

ASA_SCORE: 45.14

COIL: 0.4212

CONS_SCORE: 0.4006

DSS_SCORE: 0.5155

HELIX: 0.02

FCONS_SCORE: 0.9624

RIG_SCORE: 0.7009

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1481M	TCGA-OR-A5J5	ACC	TCGA	VLSTS	DEG_SPOP_SBC_1	0.7208
p.G1493R	DO48367	BLCA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.1111
p.P1495L	DO44338	CESC	ICGC	VLSTS	DEG_SPOP_SBC_1	0.0556
p.P1485Q	DO37452	SKCM	ICGC	VLSTS	DEG_SPOP_SBC_1	0.7035
p.R1483S	DO37439	SKCM	ICGC	VLSTS	DEG_SPOP_SBC_1	0.7427
p.S1482F	DO47309	SKCM	ICGC	VLSTS	DEG_SPOP_SBC_1	0.7982
p.R1486L	DO47303	SKCM	ICGC	VLSTS	DEG_SPOP_SBC_1	0.75
p.A1474T	DO42977	UCEC	ICGC	VLSTS	DEG_SPOP_SBC_1	0.5833
p.D1487N	DO42608	UCEC	ICGC	VLSTS	DEG_SPOP_SBC_1	0.7222
p.R1473W	SIDM00783	Colorectal Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.1111
p.R1473W	HCT-116	large_intestine	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.1111
p.L1473P	SIDM01618	B-Lymphoblastic Leukemia	GDSC	VLSTS	DEG_SPOP_SBC_1	0.1111
p.C1483R	COLO-684	endometrium	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.8301
p.Y1494H	GP5d	large_intestine	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1481:1485	VLSTS	SPOP	0.7831	More...
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	334:338	VLSTS	SPOP	0.5966	More...
Q32MK0	Myosin light chain kinase 3	DEG_SPOP_SBC_1	174:178	VLSTS	SPOP	0.9947	More...
Q6IPM2	IQ domain-containing protein E	DEG_SPOP_SBC_1	318:322	VLSTS	SPOP	0.5759	More...
Q6ZMZ0	E3 ubiquitin-protein ligase RNF19B	DEG_SPOP_SBC_1	492:496	VLSTS	SPOP	0.944	More...
Q7KZI7	Serine/threonine-protein kinase MARK2	DEG_SPOP_SBC_1	475:479	VLSTS	SPOP	0.9918	More...
Q7Z460	CLIP-associating protein 1	DEG_SPOP_SBC_1	793:797	VLSTS	SPOP	0.9931	More...
Q8TEJ3	E3 ubiquitin-protein ligase SH3RF3	DEG_SPOP_SBC_1	696:700	VLSTS	SPOP	0.9715	More...
Q92540	Nonsense-mediated mRNA decay factor SMG7	DEG_SPOP_SBC_1	526:530	VLSTS	SPOP	0.9999	More...
Q96LA8	Protein arginine N-methyltransferase 6	DEG_SPOP_SBC_1	306:310	VLSTS	SPOP	0.5624	More...
Q9H0E7	Ubiquitin carboxyl-terminal hydrolase 44	DEG_SPOP_SBC_1	245:249	VLSTS	SPOP	0.9886	More...
Q9P275	Ubiquitin carboxyl-terminal hydrolase 36	DEG_SPOP_SBC_1	578:582	VLSTS	SPOP	0.9967	More...
Q9UNZ2	NSFL1 cofactor p47	DEG_SPOP_SBC_1	267:271	VLSTS	SPOP	0.7502	More...
Q5T8P6	RNA-binding protein 26	DEG_SPOP_SBC_1	687:691	VLSTS	SPOP	0.5563	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons