DegronMD - Q9H0E7(USP44)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R276K	TCGA-AA-3672	COAD	TCGA	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.25
p.R276K	DO9010	COAD	ICGC	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.25
p.L278V	TCGA-AA-3977	COAD	TCGA	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.1944
p.L278V	DO8730	COAD	ICGC	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.1944
p.N277H	TCGA-AG-3892	READ	TCGA	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.2222
p.N277H	DO36394	READ	ICGC	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.2222
p.N277H	SIDM01588	Endometrial Carcinoma	GDSC	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.2222
p.N277H	ACH-000993	Endometrial/Uterine Cancer	CCLE	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.2222
p.S258N	TCGA-AP-A0LP	UCEC	TCGA	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.1111
p.S258N	TCGA-AP-A0LP	UCEC	TCGA	VLSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.0833
p.S258N	DO43146	UCEC	ICGC	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.1111
p.S258N	DO43146	UCEC	ICGC	VLSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.0833
p.I267T	TCGA-BS-A0UF	UCEC	TCGA	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation altering degron motif	0.5966
p.I267T	DO41488	UCEC	ICGC	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation altering degron motif	0.5966
p.D243E	TCGA-CC-A5UD	LIHC	TCGA	VLSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.2778
p.D243E	DO219552	LIHC	ICGC	VLSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.2778
p.R264Q	TCGA-FI-A2D0	UCEC	TCGA	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.2778
p.R264Q	DO43891	UCEC	ICGC	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.2778
p.R264Q	SIDM00534	Colorectal Carcinoma	GDSC	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.2778
p.R264Q	ACH-000986	Colon/Colorectal Cancer	CCLE	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.2778
p.R264Q	HT-115	large intestine	COSMIC	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.2778
p.S260F	TCGA-FW-A3R5	SKCM	TCGA	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.1667
p.S260F	DO37406	SKCM	ICGC	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.1667
p.V245A	DO233882	GACA	ICGC	VLSTS	DEG_SPOP_SBC_1	245:249	Mutation altering degron motif	0.5825
p.P266L	DO232761	PBCA	ICGC	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation altering degron motif	0.6471
p.V262F	SIDM00705	Non-Cancerous	GDSC	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.2222
p.V262F	SIDM00696	Non-Cancerous	GDSC	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.2222
p.V262F	SIDM00772	Breast Carcinoma	GDSC	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.2222
p.V262F	ACH-002369	Non-Cancerous	CCLE	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.2222
p.V262F	ACH-002383	Non-Cancerous	CCLE	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.2222
p.G279E	SIDM00589	Oral Cavity Carcinoma	GDSC	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.1667
p.T281I	SIDM00534	Colorectal Carcinoma	GDSC	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.1111
p.T281I	ACH-000986	Colon/Colorectal Cancer	CCLE	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.1111
p.T281I	HT-115	large intestine	COSMIC	PIVTPGVT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.1111

Kaplan plot for USP44 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP44

UniProt ID: Q9H0E7

Entrez ID: 84101

Protein name: Ubiquitin carboxyl-terminal hydrolase 44 (EC 3.4.19.12) (Deubiquitinating enzyme 44) (Ubiquitin thioesterase 44) (Ubiquitin-specific-processing protease 44)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP44 in