DegronMD

Uniprot ID: Q9H0E7

Source protein: Ubiquitin carboxyl-terminal hydrolase 44

Source gene: USP44

Class: DEG_SCF_FBW7_1

Location: 266:273

E3 ligase: FBXW7

DEGRON score: 0.9798

ASA_SCORE: 71.9125

COIL: 0.8705

CONS_SCORE: 0.5301

DSS_SCORE: 0.3564

HELIX: 0.0209

FCONS_SCORE: 0.9125

RIG_SCORE: 0.7608

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R276K	TCGA-AA-3672	COAD	TCGA	PIVTPGVT	DEG_SCF_FBW7_1	0.25
p.R276K	DO9010	COAD	ICGC	PIVTPGVT	DEG_SCF_FBW7_1	0.25
p.L278V	TCGA-AA-3977	COAD	TCGA	PIVTPGVT	DEG_SCF_FBW7_1	0.1944
p.L278V	DO8730	COAD	ICGC	PIVTPGVT	DEG_SCF_FBW7_1	0.1944
p.N277H	TCGA-AG-3892	READ	TCGA	PIVTPGVT	DEG_SCF_FBW7_1	0.2222
p.N277H	DO36394	READ	ICGC	PIVTPGVT	DEG_SCF_FBW7_1	0.2222
p.N277H	SIDM01588	Endometrial Carcinoma	GDSC	PIVTPGVT	DEG_SCF_FBW7_1	0.2222
p.N277H	ACH-000993	Endometrial/Uterine Cancer	CCLE	PIVTPGVT	DEG_SCF_FBW7_1	0.2222
p.S258N	TCGA-AP-A0LP	UCEC	TCGA	PIVTPGVT	DEG_SCF_FBW7_1	0.1111
p.S258N	DO43146	UCEC	ICGC	PIVTPGVT	DEG_SCF_FBW7_1	0.1111
p.I267T	TCGA-BS-A0UF	UCEC	TCGA	PIVTPGVT	DEG_SCF_FBW7_1	0.5966
p.I267T	DO41488	UCEC	ICGC	PIVTPGVT	DEG_SCF_FBW7_1	0.5966
p.R264Q	TCGA-FI-A2D0	UCEC	TCGA	PIVTPGVT	DEG_SCF_FBW7_1	0.2778
p.R264Q	DO43891	UCEC	ICGC	PIVTPGVT	DEG_SCF_FBW7_1	0.2778
p.R264Q	SIDM00534	Colorectal Carcinoma	GDSC	PIVTPGVT	DEG_SCF_FBW7_1	0.2778
p.R264Q	ACH-000986	Colon/Colorectal Cancer	CCLE	PIVTPGVT	DEG_SCF_FBW7_1	0.2778
p.R264Q	HT-115	large_intestine	COSMIC	PIVTPGVT	DEG_SCF_FBW7_1	0.2778
p.S260F	TCGA-FW-A3R5	SKCM	TCGA	PIVTPGVT	DEG_SCF_FBW7_1	0.1667
p.S260F	DO37406	SKCM	ICGC	PIVTPGVT	DEG_SCF_FBW7_1	0.1667
p.P266L	DO232761	PBCA	ICGC	PIVTPGVT	DEG_SCF_FBW7_1	0.6471
p.V262F	SIDM00705	Non-Cancerous	GDSC	PIVTPGVT	DEG_SCF_FBW7_1	0.2222
p.V262F	SIDM00696	Non-Cancerous	GDSC	PIVTPGVT	DEG_SCF_FBW7_1	0.2222
p.V262F	SIDM00772	Breast Carcinoma	GDSC	PIVTPGVT	DEG_SCF_FBW7_1	0.2222
p.V262F	ACH-002369	Non-Cancerous	CCLE	PIVTPGVT	DEG_SCF_FBW7_1	0.2222
p.V262F	ACH-002383	Non-Cancerous	CCLE	PIVTPGVT	DEG_SCF_FBW7_1	0.2222
p.G279E	SIDM00589	Oral Cavity Carcinoma	GDSC	PIVTPGVT	DEG_SCF_FBW7_1	0.1667
p.T281I	SIDM00534	Colorectal Carcinoma	GDSC	PIVTPGVT	DEG_SCF_FBW7_1	0.1111
p.T281I	ACH-000986	Colon/Colorectal Cancer	CCLE	PIVTPGVT	DEG_SCF_FBW7_1	0.1111
p.T281I	HT-115	large_intestine	COSMIC	PIVTPGVT	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PIVTPGVT

Degron related mutations and impact score

Drug responses associated with USP44 mutations

All proteins holding degron of PIVTPGVT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H0E7	Ubiquitin carboxyl-terminal hydrolase 44	DEG_SCF_FBW7_1	266:273	PIVTPGVT	FBXW7	0.9798	More...